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Impact of Maternal Age on Singleton Birthweight in Frozen Embryo Transfer Cycles

BACKGROUND: Previous studies have investigated the effect of maternal age on assisted reproductive technology success rates. However, little is known about the relationship between maternal age and neonatal birthweight in frozen embryo transfer (FET) cycles. Whether maternal age influences singleton...

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Autores principales: Ni, Zhe-xin, Wan, Kun-ming, Zhou, Zhi-hao, Kuang, Yan-ping, Yu, Chao-qin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8957095/
https://www.ncbi.nlm.nih.gov/pubmed/35345469
http://dx.doi.org/10.3389/fendo.2022.830414
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author Ni, Zhe-xin
Wan, Kun-ming
Zhou, Zhi-hao
Kuang, Yan-ping
Yu, Chao-qin
author_facet Ni, Zhe-xin
Wan, Kun-ming
Zhou, Zhi-hao
Kuang, Yan-ping
Yu, Chao-qin
author_sort Ni, Zhe-xin
collection PubMed
description BACKGROUND: Previous studies have investigated the effect of maternal age on assisted reproductive technology success rates. However, little is known about the relationship between maternal age and neonatal birthweight in frozen embryo transfer (FET) cycles. Whether maternal age influences singleton birthweight in FET cycles remains to be elucidated. METHODS: This study was conducted at a tertiary care center, involving singleton live births born to women undergoing frozen–thawed embryo transfer during the period from January 2010 to December 2017. A total of 12,565 women who fulfilled the inclusion criteria were enrolled and grouped into four groups according to the maternal age: <30, 30–34, 35–39, and ≥40 years old. A multivariable linear regression analysis was conducted to reveal the relationship between maternal age and neonatal birthweight with controlling for a number of potential confounders. RESULTS: The highest proportions of low birthweight (LBW, 4.1%), high birthweight (1.2%), preterm birth (PTB, 5.9%), and very PTB (0.9%) were found in the group over 40 years old, but no significant difference was observed among the four groups. Additionally, the 35–39-year-old group had the highest rate of very LBW (0.6%), whereas the 30–34-year-old group had the lowest rate of small for gestational age (SGA, 2.7%). However, multivariate analyses revealed that neonatal outcomes including PTB, LBW, and SGA were similar between the different maternal age groups. CONCLUSION: Grouping with different maternal age was not associated with mean birthweight and Z-scores of singletons resulting from FET.
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spelling pubmed-89570952022-03-27 Impact of Maternal Age on Singleton Birthweight in Frozen Embryo Transfer Cycles Ni, Zhe-xin Wan, Kun-ming Zhou, Zhi-hao Kuang, Yan-ping Yu, Chao-qin Front Endocrinol (Lausanne) Endocrinology BACKGROUND: Previous studies have investigated the effect of maternal age on assisted reproductive technology success rates. However, little is known about the relationship between maternal age and neonatal birthweight in frozen embryo transfer (FET) cycles. Whether maternal age influences singleton birthweight in FET cycles remains to be elucidated. METHODS: This study was conducted at a tertiary care center, involving singleton live births born to women undergoing frozen–thawed embryo transfer during the period from January 2010 to December 2017. A total of 12,565 women who fulfilled the inclusion criteria were enrolled and grouped into four groups according to the maternal age: <30, 30–34, 35–39, and ≥40 years old. A multivariable linear regression analysis was conducted to reveal the relationship between maternal age and neonatal birthweight with controlling for a number of potential confounders. RESULTS: The highest proportions of low birthweight (LBW, 4.1%), high birthweight (1.2%), preterm birth (PTB, 5.9%), and very PTB (0.9%) were found in the group over 40 years old, but no significant difference was observed among the four groups. Additionally, the 35–39-year-old group had the highest rate of very LBW (0.6%), whereas the 30–34-year-old group had the lowest rate of small for gestational age (SGA, 2.7%). However, multivariate analyses revealed that neonatal outcomes including PTB, LBW, and SGA were similar between the different maternal age groups. CONCLUSION: Grouping with different maternal age was not associated with mean birthweight and Z-scores of singletons resulting from FET. Frontiers Media S.A. 2022-03-08 /pmc/articles/PMC8957095/ /pubmed/35345469 http://dx.doi.org/10.3389/fendo.2022.830414 Text en Copyright © 2022 Ni, Wan, Zhou, Kuang and Yu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Ni, Zhe-xin
Wan, Kun-ming
Zhou, Zhi-hao
Kuang, Yan-ping
Yu, Chao-qin
Impact of Maternal Age on Singleton Birthweight in Frozen Embryo Transfer Cycles
title Impact of Maternal Age on Singleton Birthweight in Frozen Embryo Transfer Cycles
title_full Impact of Maternal Age on Singleton Birthweight in Frozen Embryo Transfer Cycles
title_fullStr Impact of Maternal Age on Singleton Birthweight in Frozen Embryo Transfer Cycles
title_full_unstemmed Impact of Maternal Age on Singleton Birthweight in Frozen Embryo Transfer Cycles
title_short Impact of Maternal Age on Singleton Birthweight in Frozen Embryo Transfer Cycles
title_sort impact of maternal age on singleton birthweight in frozen embryo transfer cycles
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8957095/
https://www.ncbi.nlm.nih.gov/pubmed/35345469
http://dx.doi.org/10.3389/fendo.2022.830414
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