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Effects of subchronic dietary exposure to the engineered nanomaterials SiO(2) and CeO(2) in C57BL/6J and 5xFAD Alzheimer model mice
BACKGROUND: There is an increasing concern about the neurotoxicity of engineered nanomaterials (NMs). To investigate the effects of subchronic oral exposures to SiO(2) and CeO(2) NMs on Alzheimer’s disease (AD)-like pathology, 5xFAD transgenic mice and their C57BL/6J littermates were fed ad libitum...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8957165/ https://www.ncbi.nlm.nih.gov/pubmed/35337343 http://dx.doi.org/10.1186/s12989-022-00461-2 |
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author | Sofranko, Adriana Wahle, Tina Kolling, Julia Heusinkveld, Harm J. Stahlmecke, Burkhard Rosenbruch, Martin Albrecht, Catrin Schins, Roel P. F. |
author_facet | Sofranko, Adriana Wahle, Tina Kolling, Julia Heusinkveld, Harm J. Stahlmecke, Burkhard Rosenbruch, Martin Albrecht, Catrin Schins, Roel P. F. |
author_sort | Sofranko, Adriana |
collection | PubMed |
description | BACKGROUND: There is an increasing concern about the neurotoxicity of engineered nanomaterials (NMs). To investigate the effects of subchronic oral exposures to SiO(2) and CeO(2) NMs on Alzheimer’s disease (AD)-like pathology, 5xFAD transgenic mice and their C57BL/6J littermates were fed ad libitum for 3 or 14 weeks with control food pellets, or pellets dosed with these respective NMs at 0.1% or 1% (w/w). Behaviour effects were evaluated by X-maze, string suspension, balance beam and open field tests. Brains were analysed for plaque load, beta-amyloid peptide levels, markers of oxidative stress and neuroinflammation. RESULTS: No marked behavioural impairments were observed in the mice exposed to SiO(2) or CeO(2) and neither treatment resulted in accelerated plaque formation, increased oxidative stress or inflammation. In contrast, the 5xFAD mice exposed to 1% CeO(2) for 14 weeks showed significantly lower hippocampal Aβ plaque load and improved locomotor activity compared to the corresponding controls. CONCLUSIONS: The findings from the present study suggest that long-term oral exposure to SiO(2) or CeO(2) NMs has no neurotoxic and AD-promoting effects. The reduced plaque burden observed in the mice following dietary CeO(2) exposure warrants further investigation to establish the underlying mechanism, given the easy applicability of this administration method. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12989-022-00461-2. |
format | Online Article Text |
id | pubmed-8957165 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-89571652022-03-27 Effects of subchronic dietary exposure to the engineered nanomaterials SiO(2) and CeO(2) in C57BL/6J and 5xFAD Alzheimer model mice Sofranko, Adriana Wahle, Tina Kolling, Julia Heusinkveld, Harm J. Stahlmecke, Burkhard Rosenbruch, Martin Albrecht, Catrin Schins, Roel P. F. Part Fibre Toxicol Research BACKGROUND: There is an increasing concern about the neurotoxicity of engineered nanomaterials (NMs). To investigate the effects of subchronic oral exposures to SiO(2) and CeO(2) NMs on Alzheimer’s disease (AD)-like pathology, 5xFAD transgenic mice and their C57BL/6J littermates were fed ad libitum for 3 or 14 weeks with control food pellets, or pellets dosed with these respective NMs at 0.1% or 1% (w/w). Behaviour effects were evaluated by X-maze, string suspension, balance beam and open field tests. Brains were analysed for plaque load, beta-amyloid peptide levels, markers of oxidative stress and neuroinflammation. RESULTS: No marked behavioural impairments were observed in the mice exposed to SiO(2) or CeO(2) and neither treatment resulted in accelerated plaque formation, increased oxidative stress or inflammation. In contrast, the 5xFAD mice exposed to 1% CeO(2) for 14 weeks showed significantly lower hippocampal Aβ plaque load and improved locomotor activity compared to the corresponding controls. CONCLUSIONS: The findings from the present study suggest that long-term oral exposure to SiO(2) or CeO(2) NMs has no neurotoxic and AD-promoting effects. The reduced plaque burden observed in the mice following dietary CeO(2) exposure warrants further investigation to establish the underlying mechanism, given the easy applicability of this administration method. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12989-022-00461-2. BioMed Central 2022-03-25 /pmc/articles/PMC8957165/ /pubmed/35337343 http://dx.doi.org/10.1186/s12989-022-00461-2 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Sofranko, Adriana Wahle, Tina Kolling, Julia Heusinkveld, Harm J. Stahlmecke, Burkhard Rosenbruch, Martin Albrecht, Catrin Schins, Roel P. F. Effects of subchronic dietary exposure to the engineered nanomaterials SiO(2) and CeO(2) in C57BL/6J and 5xFAD Alzheimer model mice |
title | Effects of subchronic dietary exposure to the engineered nanomaterials SiO(2) and CeO(2) in C57BL/6J and 5xFAD Alzheimer model mice |
title_full | Effects of subchronic dietary exposure to the engineered nanomaterials SiO(2) and CeO(2) in C57BL/6J and 5xFAD Alzheimer model mice |
title_fullStr | Effects of subchronic dietary exposure to the engineered nanomaterials SiO(2) and CeO(2) in C57BL/6J and 5xFAD Alzheimer model mice |
title_full_unstemmed | Effects of subchronic dietary exposure to the engineered nanomaterials SiO(2) and CeO(2) in C57BL/6J and 5xFAD Alzheimer model mice |
title_short | Effects of subchronic dietary exposure to the engineered nanomaterials SiO(2) and CeO(2) in C57BL/6J and 5xFAD Alzheimer model mice |
title_sort | effects of subchronic dietary exposure to the engineered nanomaterials sio(2) and ceo(2) in c57bl/6j and 5xfad alzheimer model mice |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8957165/ https://www.ncbi.nlm.nih.gov/pubmed/35337343 http://dx.doi.org/10.1186/s12989-022-00461-2 |
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