Cargando…

Molecular docking studies of salubrinal and its analogs as inhibitors of the GADD34:PP1 enzyme

The phenomenon of the endoplasmic reticulum (ER) stress as a molecular pathophysiological process underlies diseases as cancer, diabetes mellitus, myocardial infarction, neurodegenerative disorders, diseases of the urinary system, disorders associated with bone integrity, etc. To prevent ER stress,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zadorozhnii, Pavlo V., Pokotylo, Ihor O., Kiselev, Vadym V., Okhtina, Oxana V., Kharchenko, Aleksandr V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	International Association of Physical Chemists 2019
Materias:	Original Scientific Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8957232/ https://www.ncbi.nlm.nih.gov/pubmed/35350543 http://dx.doi.org/10.5599/admet.632

Ejemplares similares

GADD34 Ablation Exacerbates Retinal Degeneration in P23H RHO Mice
por: Saltykova, Irina V., et al.
Publicado: (2022)

GADD34–PP1c recruited by Smad7 dephosphorylates TGFβ type I receptor
por: Shi, Weibin, et al.
Publicado: (2004)

Neuroprotection by salubrinal treatment in global cerebral ischemia
por: Anuncibay-Soto, Berta, et al.
Publicado: (2016)

GADD34 is a modulator of autophagy during starvation
por: Gambardella, Gennaro, et al.
Publicado: (2020)

Chondroprotective effects of Salubrinal in a mouse model of osteoarthritis
por: Hamamura, K., et al.
Publicado: (2015)

Negative Regulation of GADD34 on Myofibroblasts during Cutaneous Wound Healing
por: Liu, Lintao, et al.
Publicado: (2014)

Distinctive Subcellular Inhibition of Cytokine-Induced Src by Salubrinal and Fluid Flow
por: Wan, Qiaoqiao, et al.
Publicado: (2014)

Protective Effects of Salubrinal on Liver Injury in Rat Models of Brain Death
por: Wang, Tao, et al.
Publicado: (2015)

EBNA3C interacts with Gadd34 and counteracts the unfolded protein response
por: Garrido, Jose L, et al.
Publicado: (2009)

GADD34 inhibits activation-induced apoptosis of macrophages through enhancement of autophagy
por: Ito, Sachiko, et al.
Publicado: (2015)

Synergistic Apoptosis Induction in Leukemic Cells by the Phosphatase Inhibitor Salubrinal and Proteasome Inhibitors
por: Drexler, Hannes C. A.
Publicado: (2009)

Effects of salubrinal on development of osteoclasts and osteoblasts from bone marrow-derived cells
por: Yokota, Hiroki, et al.
Publicado: (2013)

Synergistic antitumor activity of the combination of salubrinal and rapamycin against human cholangiocarcinoma cells
por: Zhao, Xiaofang, et al.
Publicado: (2016)

Neuroprotective Effect of the Inhibitor Salubrinal after Cardiac Arrest in a Rodent Model
por: Zhang, Jincheng, et al.
Publicado: (2020)

Enhancement of the Acrolein-Induced Production of Reactive Oxygen Species and Lung Injury by GADD34
por: Sun, Yang, et al.
Publicado: (2015)

GADD34 activates p53 and may have utility as a marker of atherosclerosis
por: Tomiyoshi, Go, et al.
Publicado: (2023)

Effects of growth arrest and DNA damage-inducible protein 34 (GADD34) on inflammation-induced colon cancer in mice
por: Tanaka, Yuriko, et al.
Publicado: (2015)

Advanced energy systems
por: Kharchenko, N V, et al.
Publicado: (2014)

Gadd45β and Gadd45γ are critical for regulating autoimmunity
por: Liu, Lin, et al.
Publicado: (2005)

Feedback Inhibition of the Unfolded Protein Response by GADD34-Mediated Dephosphorylation of eIF2α
por: Novoa, Isabel, et al.
Publicado: (2001)

HTLV-1 HBZ activates mTOR signaling pathway via inhibition of GADD34
por: Mukai, Risa, et al.
Publicado: (2011)

GADD34 induces cell death through inactivation of Akt following traumatic brain injury
por: Farook, J M, et al.
Publicado: (2013)

GADD34 induces cell death through inactivation of Akt following traumatic brain injury
por: Farook, J M, et al.
Publicado: (2013)

GADD34 suppresses lipopolysaccharide-induced sepsis and tissue injury through the regulation of macrophage activation
por: Ito, S, et al.
Publicado: (2016)

GADD34 Keeps the mTOR Pathway Inactivated in Endoplasmic Reticulum Stress Related Autophagy
por: Holczer, Marianna, et al.
Publicado: (2016)

All roads go to Salubrinal: endoplasmic reticulum stress, neuroprotection and glial scar formation
por: Romero-Ramírez, Lorenzo, et al.
Publicado: (2015)

Salubrinal attenuated retinal neovascularization by inhibiting CHOP-HIF1α-VEGF pathways
por: Hu, Yaguang, et al.
Publicado: (2017)

Salubrinal Alleviates Collagen-Induced Arthritis through Promoting P65 Degradation in Osteoclastogenesis
por: Wang, Ziyu, et al.
Publicado: (2021)

The Preventive Effects of Salubrinal against Pyrethroid-Induced Disruption of Adult Hippocampal Neurogenesis in Mice
por: Toltin, Abigail C., et al.
Publicado: (2023)

Geoffrey Michael Gadd
por: Gadd, Geoffrey Michael
Publicado: (2020)

Salubrinal Alleviates Pressure Overload-Induced Cardiac Hypertrophy by Inhibiting Endoplasmic Reticulum Stress Pathway
por: Rani, Shilpa, et al.
Publicado: (2017)

Binding modes of 2,4-diaminoquinazoline and 2,4-diaminopteridine analogs to P. falciparum dihydrofolate reductase enzyme: Molecular docking studies
por: Adane, L., et al.
Publicado: (2010)

Regulation of neuronal plasticity by the DNA repair associated Gadd45 proteins
por: Brito, David V.C., et al.
Publicado: (2022)

Gadd45a Is an RNA Binding Protein and Is Localized in Nuclear Speckles
por: Sytnikova, Yuliya A., et al.
Publicado: (2011)

Double-edged Gadd45
por: Powell, Kendall
Publicado: (2005)

Gadd45 in stress signaling
por: Liebermann, Dan A, et al.
Publicado: (2008)

GADD34-deficient mice develop obesity, nonalcoholic fatty liver disease, hepatic carcinoma and insulin resistance
por: Nishio, Naomi, et al.
Publicado: (2015)

Enterovirus 71 Activates GADD34 via Precursor 3CD to Promote IRES-Mediated Viral Translation
por: Li, Hui, et al.
Publicado: (2022)

Salubrinal Acts as a Dusp2 Inhibitor and Suppresses Inflammation in Anti-Collagen Antibody-Induced Arthritis
por: Hamamura, Kazunori, et al.
Publicado: (2015)

The Protective Effects of Salubrinal on the Cartilage and Subchondral Bone of the Temporomandibular Joint under Various Compressive Mechanical Stimulations
por: Wen, Juan, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_4bkbkf0poe03dpoabpeel87n8v