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Newly discovered Staphylococcus aureus serine hydrolase probe and drug targets

There is an urgent need for new diagnosis and treatment options for the bacterial pathogen Staphylococcus aureus. This review will summarize data on ten recently discovered biofilm-associated serine hydrolases called fluorophosphonate-binding hydrolases (FphA-J). Based on the summarized findings, ma...

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Detalles Bibliográficos
Autor principal: Fellner, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Association of Physical Chemists 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8957240/
https://www.ncbi.nlm.nih.gov/pubmed/35350120
http://dx.doi.org/10.5599/admet.1137
Descripción
Sumario:There is an urgent need for new diagnosis and treatment options for the bacterial pathogen Staphylococcus aureus. This review will summarize data on ten recently discovered biofilm-associated serine hydrolases called fluorophosphonate-binding hydrolases (FphA-J). Based on the summarized findings, many of these proteins represent intriguing new targets for probe and drug development.