Nicotinic acid in nanocontainers. Encapsulation and release from ion exchangers

The paper is devoted to the study of the ion exchange encapsulation of nicotinic acid in nanocontainers on polymer matrices. Dowex-50 cation exchanger, sulphonated polymer based on metacyclophanoctol, polymer zirconium phosphate, and strongly basic Dowex-1 anion exchanger are used as polymer matrice...

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Detalles Bibliográficos
Autores principales: Altshuler, Heinrich, Ostapova, Elena, Altshuler, Olga, Shkurenko, Galina, Malyshenko, Natalya, Lyrschikov, Sergey, Parshkov, Roman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Association of Physical Chemists 2018
Materias:
Original Scientific Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8957248/
https://www.ncbi.nlm.nih.gov/pubmed/35350743
http://dx.doi.org/10.5599/admet.626
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author Altshuler, Heinrich
Ostapova, Elena
Altshuler, Olga
Shkurenko, Galina
Malyshenko, Natalya
Lyrschikov, Sergey
Parshkov, Roman
author_facet Altshuler, Heinrich
Ostapova, Elena
Altshuler, Olga
Shkurenko, Galina
Malyshenko, Natalya
Lyrschikov, Sergey
Parshkov, Roman
author_sort Altshuler, Heinrich
collection PubMed
description The paper is devoted to the study of the ion exchange encapsulation of nicotinic acid in nanocontainers on polymer matrices. Dowex-50 cation exchanger, sulphonated polymer based on metacyclophanoctol, polymer zirconium phosphate, and strongly basic Dowex-1 anion exchanger are used as polymer matrices. It was confirmed that commercial ion exchangers can encapsulate up to 0.64 g of nicotinic acid per gram of polymer. The high elution rate of nicotinic acid from nanocontainers via the ion exchange mechanism makes it possible to achieve the desired pharmacokinetics of drug release in vivo.
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spelling pubmed-89572482022-03-28 Nicotinic acid in nanocontainers. Encapsulation and release from ion exchangers Altshuler, Heinrich Ostapova, Elena Altshuler, Olga Shkurenko, Galina Malyshenko, Natalya Lyrschikov, Sergey Parshkov, Roman ADMET DMPK Original Scientific Paper The paper is devoted to the study of the ion exchange encapsulation of nicotinic acid in nanocontainers on polymer matrices. Dowex-50 cation exchanger, sulphonated polymer based on metacyclophanoctol, polymer zirconium phosphate, and strongly basic Dowex-1 anion exchanger are used as polymer matrices. It was confirmed that commercial ion exchangers can encapsulate up to 0.64 g of nicotinic acid per gram of polymer. The high elution rate of nicotinic acid from nanocontainers via the ion exchange mechanism makes it possible to achieve the desired pharmacokinetics of drug release in vivo. International Association of Physical Chemists 2018-12-26 /pmc/articles/PMC8957248/ /pubmed/35350743 http://dx.doi.org/10.5599/admet.626 Text en Copyright © 2018 by the authors. https://creativecommons.org/licenses/by/3.0/This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/ (https://creativecommons.org/licenses/by/3.0/) ).
spellingShingle Original Scientific Paper
Altshuler, Heinrich
Ostapova, Elena
Altshuler, Olga
Shkurenko, Galina
Malyshenko, Natalya
Lyrschikov, Sergey
Parshkov, Roman
Nicotinic acid in nanocontainers. Encapsulation and release from ion exchangers
title Nicotinic acid in nanocontainers. Encapsulation and release from ion exchangers
title_full Nicotinic acid in nanocontainers. Encapsulation and release from ion exchangers
title_fullStr Nicotinic acid in nanocontainers. Encapsulation and release from ion exchangers
title_full_unstemmed Nicotinic acid in nanocontainers. Encapsulation and release from ion exchangers
title_short Nicotinic acid in nanocontainers. Encapsulation and release from ion exchangers
title_sort nicotinic acid in nanocontainers. encapsulation and release from ion exchangers
topic Original Scientific Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8957248/
https://www.ncbi.nlm.nih.gov/pubmed/35350743
http://dx.doi.org/10.5599/admet.626
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