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The prognostic and clinicopathological significance of desmoglein 2 in human cancers: a systematic review and meta-analysis

OBJECTIVE: The survival and clinicopathological significance of desmoglein 2 (DSG2) in various cancers is controversial. Thus, we performed this systematic review and meta-analysis to explore the preliminary prognostic value of DSG2. METHODS: Eligible studies were identified from databases including...

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Autores principales: Wang, Jiantao, Hao, Siyuan, Gu, Junjie, Rudd, Sean G., Wang, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8957267/
https://www.ncbi.nlm.nih.gov/pubmed/35345582
http://dx.doi.org/10.7717/peerj.13141
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author Wang, Jiantao
Hao, Siyuan
Gu, Junjie
Rudd, Sean G.
Wang, Yan
author_facet Wang, Jiantao
Hao, Siyuan
Gu, Junjie
Rudd, Sean G.
Wang, Yan
author_sort Wang, Jiantao
collection PubMed
description OBJECTIVE: The survival and clinicopathological significance of desmoglein 2 (DSG2) in various cancers is controversial. Thus, we performed this systematic review and meta-analysis to explore the preliminary prognostic value of DSG2. METHODS: Eligible studies were identified from databases including PubMed, the Cochrane Library, Embase, Web of Science and Scopus. Hand searches were also conducted in relevant bibliographies. We then extracted and pooled hazard ratio (HR) of overall survival (OS) and odds ratio (OR) of clinicopathological features. RESULTS: A total of 11 eligible studies containing 1,488 patients were included. Our results demonstrated that in non-small cell lung cancer (NSCLC), high DSG2 expression is associated with poor OS. However, in digestive system cancer and female reproductive system cancer, there were no statistically significant associations between OS and DSG2. CONCLUSIONS: Based on the findings of this study, high DSG2 expression is associated with worse prognosis in patients with NSCLC, and thus DSG2 expression could be a biomarker for prognosis in NSCLC.
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spelling pubmed-89572672022-03-27 The prognostic and clinicopathological significance of desmoglein 2 in human cancers: a systematic review and meta-analysis Wang, Jiantao Hao, Siyuan Gu, Junjie Rudd, Sean G. Wang, Yan PeerJ Evidence Based Medicine OBJECTIVE: The survival and clinicopathological significance of desmoglein 2 (DSG2) in various cancers is controversial. Thus, we performed this systematic review and meta-analysis to explore the preliminary prognostic value of DSG2. METHODS: Eligible studies were identified from databases including PubMed, the Cochrane Library, Embase, Web of Science and Scopus. Hand searches were also conducted in relevant bibliographies. We then extracted and pooled hazard ratio (HR) of overall survival (OS) and odds ratio (OR) of clinicopathological features. RESULTS: A total of 11 eligible studies containing 1,488 patients were included. Our results demonstrated that in non-small cell lung cancer (NSCLC), high DSG2 expression is associated with poor OS. However, in digestive system cancer and female reproductive system cancer, there were no statistically significant associations between OS and DSG2. CONCLUSIONS: Based on the findings of this study, high DSG2 expression is associated with worse prognosis in patients with NSCLC, and thus DSG2 expression could be a biomarker for prognosis in NSCLC. PeerJ Inc. 2022-03-22 /pmc/articles/PMC8957267/ /pubmed/35345582 http://dx.doi.org/10.7717/peerj.13141 Text en © 2022 Wang et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.
spellingShingle Evidence Based Medicine
Wang, Jiantao
Hao, Siyuan
Gu, Junjie
Rudd, Sean G.
Wang, Yan
The prognostic and clinicopathological significance of desmoglein 2 in human cancers: a systematic review and meta-analysis
title The prognostic and clinicopathological significance of desmoglein 2 in human cancers: a systematic review and meta-analysis
title_full The prognostic and clinicopathological significance of desmoglein 2 in human cancers: a systematic review and meta-analysis
title_fullStr The prognostic and clinicopathological significance of desmoglein 2 in human cancers: a systematic review and meta-analysis
title_full_unstemmed The prognostic and clinicopathological significance of desmoglein 2 in human cancers: a systematic review and meta-analysis
title_short The prognostic and clinicopathological significance of desmoglein 2 in human cancers: a systematic review and meta-analysis
title_sort prognostic and clinicopathological significance of desmoglein 2 in human cancers: a systematic review and meta-analysis
topic Evidence Based Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8957267/
https://www.ncbi.nlm.nih.gov/pubmed/35345582
http://dx.doi.org/10.7717/peerj.13141
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