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Antiviral potential of nanoparticles for the treatment of Coronavirus infections

BACKGROUND: On 31st December 2019 in Wuhan, China, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), was acknowledged. This virus spread quickly throughout the world causing a global pandemic. The World Health Organization declared COVID-19 a pandemic disease on 11th March 2020. Since th...

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Autores principales: Sarkar, Joy, Das, Sunandana, Aich, Sahasrabdi, Bhattacharyya, Prithu, Acharya, Krishnendu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier GmbH. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8957383/
https://www.ncbi.nlm.nih.gov/pubmed/35397331
http://dx.doi.org/10.1016/j.jtemb.2022.126977
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author Sarkar, Joy
Das, Sunandana
Aich, Sahasrabdi
Bhattacharyya, Prithu
Acharya, Krishnendu
author_facet Sarkar, Joy
Das, Sunandana
Aich, Sahasrabdi
Bhattacharyya, Prithu
Acharya, Krishnendu
author_sort Sarkar, Joy
collection PubMed
description BACKGROUND: On 31st December 2019 in Wuhan, China, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), was acknowledged. This virus spread quickly throughout the world causing a global pandemic. The World Health Organization declared COVID-19 a pandemic disease on 11th March 2020. Since then, the whole world has come together and have developed several vaccines against this deadly virus. Similarly, several alternative searches for pandemic disease therapeutics are still ongoing. One of them has been identified as nanotechnology. It has demonstrated significant promise for detecting and inhibiting a variety of viruses, including coronaviruses. Several nanoparticles, including gold nanoparticles, silver nanoparticles, quantum dots, carbon dots, graphene oxide nanoparticles, and zinc oxide nanoparticles, have previously demonstrated remarkable antiviral activity against a diverse array of viruses. OBJECTIVE: This review aims to provide a basic and comprehensive overview of COVID-19's initial global outbreak and its mechanism of infiltration into human host cells, as well as the detailed mechanism and inhibitory effects of various nanoparticles against this virus. In addition to nanoparticles, this review focuses on the role of several antiviral drugs used against COVID-19 to date. CONCLUSION: COVID-19 has severely disrupted the social and economic lives of people all over the world. Due to a lack of adequate medical facilities, countries have struggled to maintain control of the situation. Neither a drug nor a vaccine has a 100% efficacy rate. As a result, nanotechnology may be a better therapeutic alternative for this pandemic disease.
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spelling pubmed-89573832022-03-28 Antiviral potential of nanoparticles for the treatment of Coronavirus infections Sarkar, Joy Das, Sunandana Aich, Sahasrabdi Bhattacharyya, Prithu Acharya, Krishnendu J Trace Elem Med Biol Review BACKGROUND: On 31st December 2019 in Wuhan, China, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), was acknowledged. This virus spread quickly throughout the world causing a global pandemic. The World Health Organization declared COVID-19 a pandemic disease on 11th March 2020. Since then, the whole world has come together and have developed several vaccines against this deadly virus. Similarly, several alternative searches for pandemic disease therapeutics are still ongoing. One of them has been identified as nanotechnology. It has demonstrated significant promise for detecting and inhibiting a variety of viruses, including coronaviruses. Several nanoparticles, including gold nanoparticles, silver nanoparticles, quantum dots, carbon dots, graphene oxide nanoparticles, and zinc oxide nanoparticles, have previously demonstrated remarkable antiviral activity against a diverse array of viruses. OBJECTIVE: This review aims to provide a basic and comprehensive overview of COVID-19's initial global outbreak and its mechanism of infiltration into human host cells, as well as the detailed mechanism and inhibitory effects of various nanoparticles against this virus. In addition to nanoparticles, this review focuses on the role of several antiviral drugs used against COVID-19 to date. CONCLUSION: COVID-19 has severely disrupted the social and economic lives of people all over the world. Due to a lack of adequate medical facilities, countries have struggled to maintain control of the situation. Neither a drug nor a vaccine has a 100% efficacy rate. As a result, nanotechnology may be a better therapeutic alternative for this pandemic disease. Elsevier GmbH. 2022-07 2022-03-26 /pmc/articles/PMC8957383/ /pubmed/35397331 http://dx.doi.org/10.1016/j.jtemb.2022.126977 Text en © 2022 Elsevier GmbH. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Review
Sarkar, Joy
Das, Sunandana
Aich, Sahasrabdi
Bhattacharyya, Prithu
Acharya, Krishnendu
Antiviral potential of nanoparticles for the treatment of Coronavirus infections
title Antiviral potential of nanoparticles for the treatment of Coronavirus infections
title_full Antiviral potential of nanoparticles for the treatment of Coronavirus infections
title_fullStr Antiviral potential of nanoparticles for the treatment of Coronavirus infections
title_full_unstemmed Antiviral potential of nanoparticles for the treatment of Coronavirus infections
title_short Antiviral potential of nanoparticles for the treatment of Coronavirus infections
title_sort antiviral potential of nanoparticles for the treatment of coronavirus infections
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8957383/
https://www.ncbi.nlm.nih.gov/pubmed/35397331
http://dx.doi.org/10.1016/j.jtemb.2022.126977
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