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MiR-1270 Suppresses the Malignant Progression of Breast Cancer via Targeting MMD2

We aimed to detect the clinical significance of microRNA-1270 (miR-1270) in breast cancer (BCa) development and its potential influence on malignant phenotypes of BCa cells. The miR-1270 level in paired BCa and paracancerous tissues was detected. The Kaplan–Meier method was used for the prognosis an...

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Detalles Bibliográficos
Autores principales: Hu, Shaojun, Song, Yang, Zhou, Yu, Jiao, Yu, Wang, Song
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8957424/
https://www.ncbi.nlm.nih.gov/pubmed/35345650
http://dx.doi.org/10.1155/2022/3677720
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author Hu, Shaojun
Song, Yang
Zhou, Yu
Jiao, Yu
Wang, Song
author_facet Hu, Shaojun
Song, Yang
Zhou, Yu
Jiao, Yu
Wang, Song
author_sort Hu, Shaojun
collection PubMed
description We aimed to detect the clinical significance of microRNA-1270 (miR-1270) in breast cancer (BCa) development and its potential influence on malignant phenotypes of BCa cells. The miR-1270 level in paired BCa and paracancerous tissues was detected. The Kaplan–Meier method was used for the prognosis analysis of miR-1270 in BCa. The biofunctions of miR-1270 in apoptosis and proliferation of breast cancer cells were evaluated. Downstream target of miR-1270 was predicted and confirmed. The involvement of monocyte to macrophage differentiation associated 2 (MMD2) in BCa development was finally illustrated. miR-1270 was lowly expressed in BCa tissues. Lowly expressed miR-1270 was associated with tumor staging, larger tumor size, and also worse prognostic results in patients with BCa. miR-1270 overexpression suppressed proliferation and increased apoptotic rate of BCa cells. Further exploration showed that MMD2 might be the target of miR-1270. MMD2 was upregulated in BCa tissues and negatively correlated to miR-1270 level. Importantly, MMD2 significantly neutralized the above biofunctions of miR-1270 in malignant phenotypes of BCa. Lowly expressed miR-1270 is a hallmark of poor prognosis in patients with BCa. It inhibits proliferative ability and increases apoptosis in BCa by negatively regulating the MMD2 level.
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spelling pubmed-89574242022-03-27 MiR-1270 Suppresses the Malignant Progression of Breast Cancer via Targeting MMD2 Hu, Shaojun Song, Yang Zhou, Yu Jiao, Yu Wang, Song J Healthc Eng Research Article We aimed to detect the clinical significance of microRNA-1270 (miR-1270) in breast cancer (BCa) development and its potential influence on malignant phenotypes of BCa cells. The miR-1270 level in paired BCa and paracancerous tissues was detected. The Kaplan–Meier method was used for the prognosis analysis of miR-1270 in BCa. The biofunctions of miR-1270 in apoptosis and proliferation of breast cancer cells were evaluated. Downstream target of miR-1270 was predicted and confirmed. The involvement of monocyte to macrophage differentiation associated 2 (MMD2) in BCa development was finally illustrated. miR-1270 was lowly expressed in BCa tissues. Lowly expressed miR-1270 was associated with tumor staging, larger tumor size, and also worse prognostic results in patients with BCa. miR-1270 overexpression suppressed proliferation and increased apoptotic rate of BCa cells. Further exploration showed that MMD2 might be the target of miR-1270. MMD2 was upregulated in BCa tissues and negatively correlated to miR-1270 level. Importantly, MMD2 significantly neutralized the above biofunctions of miR-1270 in malignant phenotypes of BCa. Lowly expressed miR-1270 is a hallmark of poor prognosis in patients with BCa. It inhibits proliferative ability and increases apoptosis in BCa by negatively regulating the MMD2 level. Hindawi 2022-03-19 /pmc/articles/PMC8957424/ /pubmed/35345650 http://dx.doi.org/10.1155/2022/3677720 Text en Copyright © 2022 Shaojun Hu et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Hu, Shaojun
Song, Yang
Zhou, Yu
Jiao, Yu
Wang, Song
MiR-1270 Suppresses the Malignant Progression of Breast Cancer via Targeting MMD2
title MiR-1270 Suppresses the Malignant Progression of Breast Cancer via Targeting MMD2
title_full MiR-1270 Suppresses the Malignant Progression of Breast Cancer via Targeting MMD2
title_fullStr MiR-1270 Suppresses the Malignant Progression of Breast Cancer via Targeting MMD2
title_full_unstemmed MiR-1270 Suppresses the Malignant Progression of Breast Cancer via Targeting MMD2
title_short MiR-1270 Suppresses the Malignant Progression of Breast Cancer via Targeting MMD2
title_sort mir-1270 suppresses the malignant progression of breast cancer via targeting mmd2
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8957424/
https://www.ncbi.nlm.nih.gov/pubmed/35345650
http://dx.doi.org/10.1155/2022/3677720
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