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MiR-1270 Suppresses the Malignant Progression of Breast Cancer via Targeting MMD2
We aimed to detect the clinical significance of microRNA-1270 (miR-1270) in breast cancer (BCa) development and its potential influence on malignant phenotypes of BCa cells. The miR-1270 level in paired BCa and paracancerous tissues was detected. The Kaplan–Meier method was used for the prognosis an...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8957424/ https://www.ncbi.nlm.nih.gov/pubmed/35345650 http://dx.doi.org/10.1155/2022/3677720 |
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author | Hu, Shaojun Song, Yang Zhou, Yu Jiao, Yu Wang, Song |
author_facet | Hu, Shaojun Song, Yang Zhou, Yu Jiao, Yu Wang, Song |
author_sort | Hu, Shaojun |
collection | PubMed |
description | We aimed to detect the clinical significance of microRNA-1270 (miR-1270) in breast cancer (BCa) development and its potential influence on malignant phenotypes of BCa cells. The miR-1270 level in paired BCa and paracancerous tissues was detected. The Kaplan–Meier method was used for the prognosis analysis of miR-1270 in BCa. The biofunctions of miR-1270 in apoptosis and proliferation of breast cancer cells were evaluated. Downstream target of miR-1270 was predicted and confirmed. The involvement of monocyte to macrophage differentiation associated 2 (MMD2) in BCa development was finally illustrated. miR-1270 was lowly expressed in BCa tissues. Lowly expressed miR-1270 was associated with tumor staging, larger tumor size, and also worse prognostic results in patients with BCa. miR-1270 overexpression suppressed proliferation and increased apoptotic rate of BCa cells. Further exploration showed that MMD2 might be the target of miR-1270. MMD2 was upregulated in BCa tissues and negatively correlated to miR-1270 level. Importantly, MMD2 significantly neutralized the above biofunctions of miR-1270 in malignant phenotypes of BCa. Lowly expressed miR-1270 is a hallmark of poor prognosis in patients with BCa. It inhibits proliferative ability and increases apoptosis in BCa by negatively regulating the MMD2 level. |
format | Online Article Text |
id | pubmed-8957424 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-89574242022-03-27 MiR-1270 Suppresses the Malignant Progression of Breast Cancer via Targeting MMD2 Hu, Shaojun Song, Yang Zhou, Yu Jiao, Yu Wang, Song J Healthc Eng Research Article We aimed to detect the clinical significance of microRNA-1270 (miR-1270) in breast cancer (BCa) development and its potential influence on malignant phenotypes of BCa cells. The miR-1270 level in paired BCa and paracancerous tissues was detected. The Kaplan–Meier method was used for the prognosis analysis of miR-1270 in BCa. The biofunctions of miR-1270 in apoptosis and proliferation of breast cancer cells were evaluated. Downstream target of miR-1270 was predicted and confirmed. The involvement of monocyte to macrophage differentiation associated 2 (MMD2) in BCa development was finally illustrated. miR-1270 was lowly expressed in BCa tissues. Lowly expressed miR-1270 was associated with tumor staging, larger tumor size, and also worse prognostic results in patients with BCa. miR-1270 overexpression suppressed proliferation and increased apoptotic rate of BCa cells. Further exploration showed that MMD2 might be the target of miR-1270. MMD2 was upregulated in BCa tissues and negatively correlated to miR-1270 level. Importantly, MMD2 significantly neutralized the above biofunctions of miR-1270 in malignant phenotypes of BCa. Lowly expressed miR-1270 is a hallmark of poor prognosis in patients with BCa. It inhibits proliferative ability and increases apoptosis in BCa by negatively regulating the MMD2 level. Hindawi 2022-03-19 /pmc/articles/PMC8957424/ /pubmed/35345650 http://dx.doi.org/10.1155/2022/3677720 Text en Copyright © 2022 Shaojun Hu et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Hu, Shaojun Song, Yang Zhou, Yu Jiao, Yu Wang, Song MiR-1270 Suppresses the Malignant Progression of Breast Cancer via Targeting MMD2 |
title | MiR-1270 Suppresses the Malignant Progression of Breast Cancer via Targeting MMD2 |
title_full | MiR-1270 Suppresses the Malignant Progression of Breast Cancer via Targeting MMD2 |
title_fullStr | MiR-1270 Suppresses the Malignant Progression of Breast Cancer via Targeting MMD2 |
title_full_unstemmed | MiR-1270 Suppresses the Malignant Progression of Breast Cancer via Targeting MMD2 |
title_short | MiR-1270 Suppresses the Malignant Progression of Breast Cancer via Targeting MMD2 |
title_sort | mir-1270 suppresses the malignant progression of breast cancer via targeting mmd2 |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8957424/ https://www.ncbi.nlm.nih.gov/pubmed/35345650 http://dx.doi.org/10.1155/2022/3677720 |
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