Cargando…
The Role of Histone Post-Translational Modifications in Merkel Cell Carcinoma
Merkel Cell Carcinoma (MCC) is a rare but highly aggressive form of non–melanoma skin cancer whose 5-year survival rate is 63%. Merkel cell polyomavirus (MCPyV), a small DNA tumor virus, is the etiological agent of MCC. Although representing a small proportion of MCC cases, MCPyV-negative MCCs have...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8957841/ https://www.ncbi.nlm.nih.gov/pubmed/35350569 http://dx.doi.org/10.3389/fonc.2022.832047 |
_version_ | 1784676818904678400 |
---|---|
author | Mazziotta, Chiara Lanzillotti, Carmen Gafà, Roberta Touzé, Antoine Durand, Marie-Alice Martini, Fernanda Rotondo, John Charles |
author_facet | Mazziotta, Chiara Lanzillotti, Carmen Gafà, Roberta Touzé, Antoine Durand, Marie-Alice Martini, Fernanda Rotondo, John Charles |
author_sort | Mazziotta, Chiara |
collection | PubMed |
description | Merkel Cell Carcinoma (MCC) is a rare but highly aggressive form of non–melanoma skin cancer whose 5-year survival rate is 63%. Merkel cell polyomavirus (MCPyV), a small DNA tumor virus, is the etiological agent of MCC. Although representing a small proportion of MCC cases, MCPyV-negative MCCs have also been identified. The role of epigenetic mechanisms, including histone post-translational modifications (PTMs) in MCC, have been only partially determined. This review aims to describe the most recent progress on PTMs and their regulative factors in the context of MCC onset/development, providing an overview of current findings on both MCC subtypes. An outline of current knowledge on the potential employment of PTMs and related factors as diagnostic and prognostic markers, as well as novel treatment strategies targeting the reversibility of PTMs for MCC therapy is provided. Recent research shows that PTMs are emerging as important epigenetic players involved in MCC onset/development, and therefore may show a potential clinical significance. Deeper and integrated knowledge of currently known PTM dysregulations is of paramount importance in order to understand the molecular basis of MCC and improve the diagnosis, prognosis, and therapeutic options for this deadly tumor. |
format | Online Article Text |
id | pubmed-8957841 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-89578412022-03-28 The Role of Histone Post-Translational Modifications in Merkel Cell Carcinoma Mazziotta, Chiara Lanzillotti, Carmen Gafà, Roberta Touzé, Antoine Durand, Marie-Alice Martini, Fernanda Rotondo, John Charles Front Oncol Oncology Merkel Cell Carcinoma (MCC) is a rare but highly aggressive form of non–melanoma skin cancer whose 5-year survival rate is 63%. Merkel cell polyomavirus (MCPyV), a small DNA tumor virus, is the etiological agent of MCC. Although representing a small proportion of MCC cases, MCPyV-negative MCCs have also been identified. The role of epigenetic mechanisms, including histone post-translational modifications (PTMs) in MCC, have been only partially determined. This review aims to describe the most recent progress on PTMs and their regulative factors in the context of MCC onset/development, providing an overview of current findings on both MCC subtypes. An outline of current knowledge on the potential employment of PTMs and related factors as diagnostic and prognostic markers, as well as novel treatment strategies targeting the reversibility of PTMs for MCC therapy is provided. Recent research shows that PTMs are emerging as important epigenetic players involved in MCC onset/development, and therefore may show a potential clinical significance. Deeper and integrated knowledge of currently known PTM dysregulations is of paramount importance in order to understand the molecular basis of MCC and improve the diagnosis, prognosis, and therapeutic options for this deadly tumor. Frontiers Media S.A. 2022-03-08 /pmc/articles/PMC8957841/ /pubmed/35350569 http://dx.doi.org/10.3389/fonc.2022.832047 Text en Copyright © 2022 Mazziotta, Lanzillotti, Gafà, Touzé, Durand, Martini and Rotondo https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Mazziotta, Chiara Lanzillotti, Carmen Gafà, Roberta Touzé, Antoine Durand, Marie-Alice Martini, Fernanda Rotondo, John Charles The Role of Histone Post-Translational Modifications in Merkel Cell Carcinoma |
title | The Role of Histone Post-Translational Modifications in Merkel Cell Carcinoma |
title_full | The Role of Histone Post-Translational Modifications in Merkel Cell Carcinoma |
title_fullStr | The Role of Histone Post-Translational Modifications in Merkel Cell Carcinoma |
title_full_unstemmed | The Role of Histone Post-Translational Modifications in Merkel Cell Carcinoma |
title_short | The Role of Histone Post-Translational Modifications in Merkel Cell Carcinoma |
title_sort | role of histone post-translational modifications in merkel cell carcinoma |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8957841/ https://www.ncbi.nlm.nih.gov/pubmed/35350569 http://dx.doi.org/10.3389/fonc.2022.832047 |
work_keys_str_mv | AT mazziottachiara theroleofhistoneposttranslationalmodificationsinmerkelcellcarcinoma AT lanzillotticarmen theroleofhistoneposttranslationalmodificationsinmerkelcellcarcinoma AT gafaroberta theroleofhistoneposttranslationalmodificationsinmerkelcellcarcinoma AT touzeantoine theroleofhistoneposttranslationalmodificationsinmerkelcellcarcinoma AT durandmariealice theroleofhistoneposttranslationalmodificationsinmerkelcellcarcinoma AT martinifernanda theroleofhistoneposttranslationalmodificationsinmerkelcellcarcinoma AT rotondojohncharles theroleofhistoneposttranslationalmodificationsinmerkelcellcarcinoma AT mazziottachiara roleofhistoneposttranslationalmodificationsinmerkelcellcarcinoma AT lanzillotticarmen roleofhistoneposttranslationalmodificationsinmerkelcellcarcinoma AT gafaroberta roleofhistoneposttranslationalmodificationsinmerkelcellcarcinoma AT touzeantoine roleofhistoneposttranslationalmodificationsinmerkelcellcarcinoma AT durandmariealice roleofhistoneposttranslationalmodificationsinmerkelcellcarcinoma AT martinifernanda roleofhistoneposttranslationalmodificationsinmerkelcellcarcinoma AT rotondojohncharles roleofhistoneposttranslationalmodificationsinmerkelcellcarcinoma |