Cargando…
Insight Into the Mechanism of Exercise Preconditioning in Ischemic Stroke
Exercise preconditioning has attracted extensive attention to induce endogenous neuroprotection and has become the hotspot in neurotherapy. The training exercise is given multiple times before cerebral ischemia, effectively inducing ischemic tolerance and alleviating secondary brain damage post-stro...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8957886/ https://www.ncbi.nlm.nih.gov/pubmed/35350755 http://dx.doi.org/10.3389/fphar.2022.866360 |
_version_ | 1784676829019242496 |
---|---|
author | Zhu, Yuanhan Sun, Yulin Hu, Jichao Pan, Zhuoer |
author_facet | Zhu, Yuanhan Sun, Yulin Hu, Jichao Pan, Zhuoer |
author_sort | Zhu, Yuanhan |
collection | PubMed |
description | Exercise preconditioning has attracted extensive attention to induce endogenous neuroprotection and has become the hotspot in neurotherapy. The training exercise is given multiple times before cerebral ischemia, effectively inducing ischemic tolerance and alleviating secondary brain damage post-stroke. Compared with other preconditioning methods, the main advantages of exercise include easy clinical operation and being readily accepted by patients. However, the specific mechanism behind exercise preconditioning to ameliorate brain injury is complex. It involves multi-pathway and multi-target regulation, including regulation of inflammatory response, oxidative stress, apoptosis inhibition, and neurogenesis promotion. The current review summarizes the recent studies on the mechanism of neuroprotection induced by exercise, providing the theoretical basis of applying exercise therapy to prevent and treat ischemic stroke. In addition, we highlight the various limitations and future challenges of translational medicine from fundamental study to clinical application. |
format | Online Article Text |
id | pubmed-8957886 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-89578862022-03-28 Insight Into the Mechanism of Exercise Preconditioning in Ischemic Stroke Zhu, Yuanhan Sun, Yulin Hu, Jichao Pan, Zhuoer Front Pharmacol Pharmacology Exercise preconditioning has attracted extensive attention to induce endogenous neuroprotection and has become the hotspot in neurotherapy. The training exercise is given multiple times before cerebral ischemia, effectively inducing ischemic tolerance and alleviating secondary brain damage post-stroke. Compared with other preconditioning methods, the main advantages of exercise include easy clinical operation and being readily accepted by patients. However, the specific mechanism behind exercise preconditioning to ameliorate brain injury is complex. It involves multi-pathway and multi-target regulation, including regulation of inflammatory response, oxidative stress, apoptosis inhibition, and neurogenesis promotion. The current review summarizes the recent studies on the mechanism of neuroprotection induced by exercise, providing the theoretical basis of applying exercise therapy to prevent and treat ischemic stroke. In addition, we highlight the various limitations and future challenges of translational medicine from fundamental study to clinical application. Frontiers Media S.A. 2022-03-08 /pmc/articles/PMC8957886/ /pubmed/35350755 http://dx.doi.org/10.3389/fphar.2022.866360 Text en Copyright © 2022 Zhu, Sun, Hu and Pan. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Zhu, Yuanhan Sun, Yulin Hu, Jichao Pan, Zhuoer Insight Into the Mechanism of Exercise Preconditioning in Ischemic Stroke |
title | Insight Into the Mechanism of Exercise Preconditioning in Ischemic Stroke |
title_full | Insight Into the Mechanism of Exercise Preconditioning in Ischemic Stroke |
title_fullStr | Insight Into the Mechanism of Exercise Preconditioning in Ischemic Stroke |
title_full_unstemmed | Insight Into the Mechanism of Exercise Preconditioning in Ischemic Stroke |
title_short | Insight Into the Mechanism of Exercise Preconditioning in Ischemic Stroke |
title_sort | insight into the mechanism of exercise preconditioning in ischemic stroke |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8957886/ https://www.ncbi.nlm.nih.gov/pubmed/35350755 http://dx.doi.org/10.3389/fphar.2022.866360 |
work_keys_str_mv | AT zhuyuanhan insightintothemechanismofexercisepreconditioninginischemicstroke AT sunyulin insightintothemechanismofexercisepreconditioninginischemicstroke AT hujichao insightintothemechanismofexercisepreconditioninginischemicstroke AT panzhuoer insightintothemechanismofexercisepreconditioninginischemicstroke |