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Best Practices for Probiotic Research in Athletic and Physically Active Populations: Guidance for Future Randomized Controlled Trials

Probiotic supplementation, traditionally used for the prevention or treatment of a variety of disease indications, is now recognized in a variety of population groups including athletes and those physically active for improving general health and performance. However, experimental and clinical trial...

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Autores principales: Mohr, Alex E., Pugh, Jamie, O'Sullivan, Orla, Black, Katherine, Townsend, Jeremy R., Pyne, David B., Wardenaar, Floris C., West, Nicholas P., Whisner, Corrie M., McFarland, Lynne V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8957944/
https://www.ncbi.nlm.nih.gov/pubmed/35350412
http://dx.doi.org/10.3389/fnut.2022.809983
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author Mohr, Alex E.
Pugh, Jamie
O'Sullivan, Orla
Black, Katherine
Townsend, Jeremy R.
Pyne, David B.
Wardenaar, Floris C.
West, Nicholas P.
Whisner, Corrie M.
McFarland, Lynne V.
author_facet Mohr, Alex E.
Pugh, Jamie
O'Sullivan, Orla
Black, Katherine
Townsend, Jeremy R.
Pyne, David B.
Wardenaar, Floris C.
West, Nicholas P.
Whisner, Corrie M.
McFarland, Lynne V.
author_sort Mohr, Alex E.
collection PubMed
description Probiotic supplementation, traditionally used for the prevention or treatment of a variety of disease indications, is now recognized in a variety of population groups including athletes and those physically active for improving general health and performance. However, experimental and clinical trials with probiotics commonly suffer from design flaws and different outcome measures, making comparison and synthesis of conclusions difficult. Here we review current randomized controlled trials (RCTs) using probiotics for performance improvement, prevention of common illnesses, or general health, in a specific target population (athletes and those physically active). Future RCTs should address the key elements of (1) properly defining and characterizing a probiotic intervention, (2) study design factors, (3) study population characteristics, and (4) outcome measures, that will allow valid conclusions to be drawn. Careful evaluation and implementation of these elements should yield improved trials, which will better facilitate the generation of evidence-based probiotic supplementation recommendations for athletes and physically active individuals.
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spelling pubmed-89579442022-03-28 Best Practices for Probiotic Research in Athletic and Physically Active Populations: Guidance for Future Randomized Controlled Trials Mohr, Alex E. Pugh, Jamie O'Sullivan, Orla Black, Katherine Townsend, Jeremy R. Pyne, David B. Wardenaar, Floris C. West, Nicholas P. Whisner, Corrie M. McFarland, Lynne V. Front Nutr Nutrition Probiotic supplementation, traditionally used for the prevention or treatment of a variety of disease indications, is now recognized in a variety of population groups including athletes and those physically active for improving general health and performance. However, experimental and clinical trials with probiotics commonly suffer from design flaws and different outcome measures, making comparison and synthesis of conclusions difficult. Here we review current randomized controlled trials (RCTs) using probiotics for performance improvement, prevention of common illnesses, or general health, in a specific target population (athletes and those physically active). Future RCTs should address the key elements of (1) properly defining and characterizing a probiotic intervention, (2) study design factors, (3) study population characteristics, and (4) outcome measures, that will allow valid conclusions to be drawn. Careful evaluation and implementation of these elements should yield improved trials, which will better facilitate the generation of evidence-based probiotic supplementation recommendations for athletes and physically active individuals. Frontiers Media S.A. 2022-03-08 /pmc/articles/PMC8957944/ /pubmed/35350412 http://dx.doi.org/10.3389/fnut.2022.809983 Text en Copyright © 2022 Mohr, Pugh, O'Sullivan, Black, Townsend, Pyne, Wardenaar, West, Whisner and McFarland. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Nutrition
Mohr, Alex E.
Pugh, Jamie
O'Sullivan, Orla
Black, Katherine
Townsend, Jeremy R.
Pyne, David B.
Wardenaar, Floris C.
West, Nicholas P.
Whisner, Corrie M.
McFarland, Lynne V.
Best Practices for Probiotic Research in Athletic and Physically Active Populations: Guidance for Future Randomized Controlled Trials
title Best Practices for Probiotic Research in Athletic and Physically Active Populations: Guidance for Future Randomized Controlled Trials
title_full Best Practices for Probiotic Research in Athletic and Physically Active Populations: Guidance for Future Randomized Controlled Trials
title_fullStr Best Practices for Probiotic Research in Athletic and Physically Active Populations: Guidance for Future Randomized Controlled Trials
title_full_unstemmed Best Practices for Probiotic Research in Athletic and Physically Active Populations: Guidance for Future Randomized Controlled Trials
title_short Best Practices for Probiotic Research in Athletic and Physically Active Populations: Guidance for Future Randomized Controlled Trials
title_sort best practices for probiotic research in athletic and physically active populations: guidance for future randomized controlled trials
topic Nutrition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8957944/
https://www.ncbi.nlm.nih.gov/pubmed/35350412
http://dx.doi.org/10.3389/fnut.2022.809983
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