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Online Accurate Detection of Breath Acetone Using Metal Oxide Semiconductor Gas Sensor and Diffusive Gas Separation
Breath acetone (BrAce) level is an indicator of lipid oxidation rate, which is crucial for evaluating the status of ketoacidosis, ketogenic diet, and fat burning during exercise. Despite its usefulness, detecting BrAce accurately is challenging because exhaled breath contains an enormous variety of...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8958005/ https://www.ncbi.nlm.nih.gov/pubmed/35350181 http://dx.doi.org/10.3389/fbioe.2022.861950 |
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author | Dong, Hao Qian, Libin Cui, Yaoxuan Zheng, Xubin Cheng, Chen Cao, Qingpeng Xu, Feng Wang, Jin Chen, Xing Wang, Di |
author_facet | Dong, Hao Qian, Libin Cui, Yaoxuan Zheng, Xubin Cheng, Chen Cao, Qingpeng Xu, Feng Wang, Jin Chen, Xing Wang, Di |
author_sort | Dong, Hao |
collection | PubMed |
description | Breath acetone (BrAce) level is an indicator of lipid oxidation rate, which is crucial for evaluating the status of ketoacidosis, ketogenic diet, and fat burning during exercise. Despite its usefulness, detecting BrAce accurately is challenging because exhaled breath contains an enormous variety of compounds. Although many sensors and devices have been developed for BrAce measurement, most of them were tested with only synthetic or spiked breath samples, and few can detect low concentration BrAce in an online manner, which is critical for extending application areas and the wide acceptance of the technology. Here, we show that online detection of BrAce can be achieved using a metal oxide semiconductor acetone sensor. The high accuracy measurement of low concentration BrAce was enabled by separating major interference gases utilizing their large diffusion coefficients, and the accuracy is further improved by the correction of humidity effect. We anticipate that the approach can push BrAce measurement closer to being useful for various applications. |
format | Online Article Text |
id | pubmed-8958005 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-89580052022-03-28 Online Accurate Detection of Breath Acetone Using Metal Oxide Semiconductor Gas Sensor and Diffusive Gas Separation Dong, Hao Qian, Libin Cui, Yaoxuan Zheng, Xubin Cheng, Chen Cao, Qingpeng Xu, Feng Wang, Jin Chen, Xing Wang, Di Front Bioeng Biotechnol Bioengineering and Biotechnology Breath acetone (BrAce) level is an indicator of lipid oxidation rate, which is crucial for evaluating the status of ketoacidosis, ketogenic diet, and fat burning during exercise. Despite its usefulness, detecting BrAce accurately is challenging because exhaled breath contains an enormous variety of compounds. Although many sensors and devices have been developed for BrAce measurement, most of them were tested with only synthetic or spiked breath samples, and few can detect low concentration BrAce in an online manner, which is critical for extending application areas and the wide acceptance of the technology. Here, we show that online detection of BrAce can be achieved using a metal oxide semiconductor acetone sensor. The high accuracy measurement of low concentration BrAce was enabled by separating major interference gases utilizing their large diffusion coefficients, and the accuracy is further improved by the correction of humidity effect. We anticipate that the approach can push BrAce measurement closer to being useful for various applications. Frontiers Media S.A. 2022-03-08 /pmc/articles/PMC8958005/ /pubmed/35350181 http://dx.doi.org/10.3389/fbioe.2022.861950 Text en Copyright © 2022 Dong, Qian, Cui, Zheng, Cheng, Cao, Xu, Wang, Chen and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Bioengineering and Biotechnology Dong, Hao Qian, Libin Cui, Yaoxuan Zheng, Xubin Cheng, Chen Cao, Qingpeng Xu, Feng Wang, Jin Chen, Xing Wang, Di Online Accurate Detection of Breath Acetone Using Metal Oxide Semiconductor Gas Sensor and Diffusive Gas Separation |
title | Online Accurate Detection of Breath Acetone Using Metal Oxide Semiconductor Gas Sensor and Diffusive Gas Separation |
title_full | Online Accurate Detection of Breath Acetone Using Metal Oxide Semiconductor Gas Sensor and Diffusive Gas Separation |
title_fullStr | Online Accurate Detection of Breath Acetone Using Metal Oxide Semiconductor Gas Sensor and Diffusive Gas Separation |
title_full_unstemmed | Online Accurate Detection of Breath Acetone Using Metal Oxide Semiconductor Gas Sensor and Diffusive Gas Separation |
title_short | Online Accurate Detection of Breath Acetone Using Metal Oxide Semiconductor Gas Sensor and Diffusive Gas Separation |
title_sort | online accurate detection of breath acetone using metal oxide semiconductor gas sensor and diffusive gas separation |
topic | Bioengineering and Biotechnology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8958005/ https://www.ncbi.nlm.nih.gov/pubmed/35350181 http://dx.doi.org/10.3389/fbioe.2022.861950 |
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