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Online Accurate Detection of Breath Acetone Using Metal Oxide Semiconductor Gas Sensor and Diffusive Gas Separation

Breath acetone (BrAce) level is an indicator of lipid oxidation rate, which is crucial for evaluating the status of ketoacidosis, ketogenic diet, and fat burning during exercise. Despite its usefulness, detecting BrAce accurately is challenging because exhaled breath contains an enormous variety of...

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Autores principales: Dong, Hao, Qian, Libin, Cui, Yaoxuan, Zheng, Xubin, Cheng, Chen, Cao, Qingpeng, Xu, Feng, Wang, Jin, Chen, Xing, Wang, Di
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8958005/
https://www.ncbi.nlm.nih.gov/pubmed/35350181
http://dx.doi.org/10.3389/fbioe.2022.861950
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author Dong, Hao
Qian, Libin
Cui, Yaoxuan
Zheng, Xubin
Cheng, Chen
Cao, Qingpeng
Xu, Feng
Wang, Jin
Chen, Xing
Wang, Di
author_facet Dong, Hao
Qian, Libin
Cui, Yaoxuan
Zheng, Xubin
Cheng, Chen
Cao, Qingpeng
Xu, Feng
Wang, Jin
Chen, Xing
Wang, Di
author_sort Dong, Hao
collection PubMed
description Breath acetone (BrAce) level is an indicator of lipid oxidation rate, which is crucial for evaluating the status of ketoacidosis, ketogenic diet, and fat burning during exercise. Despite its usefulness, detecting BrAce accurately is challenging because exhaled breath contains an enormous variety of compounds. Although many sensors and devices have been developed for BrAce measurement, most of them were tested with only synthetic or spiked breath samples, and few can detect low concentration BrAce in an online manner, which is critical for extending application areas and the wide acceptance of the technology. Here, we show that online detection of BrAce can be achieved using a metal oxide semiconductor acetone sensor. The high accuracy measurement of low concentration BrAce was enabled by separating major interference gases utilizing their large diffusion coefficients, and the accuracy is further improved by the correction of humidity effect. We anticipate that the approach can push BrAce measurement closer to being useful for various applications.
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spelling pubmed-89580052022-03-28 Online Accurate Detection of Breath Acetone Using Metal Oxide Semiconductor Gas Sensor and Diffusive Gas Separation Dong, Hao Qian, Libin Cui, Yaoxuan Zheng, Xubin Cheng, Chen Cao, Qingpeng Xu, Feng Wang, Jin Chen, Xing Wang, Di Front Bioeng Biotechnol Bioengineering and Biotechnology Breath acetone (BrAce) level is an indicator of lipid oxidation rate, which is crucial for evaluating the status of ketoacidosis, ketogenic diet, and fat burning during exercise. Despite its usefulness, detecting BrAce accurately is challenging because exhaled breath contains an enormous variety of compounds. Although many sensors and devices have been developed for BrAce measurement, most of them were tested with only synthetic or spiked breath samples, and few can detect low concentration BrAce in an online manner, which is critical for extending application areas and the wide acceptance of the technology. Here, we show that online detection of BrAce can be achieved using a metal oxide semiconductor acetone sensor. The high accuracy measurement of low concentration BrAce was enabled by separating major interference gases utilizing their large diffusion coefficients, and the accuracy is further improved by the correction of humidity effect. We anticipate that the approach can push BrAce measurement closer to being useful for various applications. Frontiers Media S.A. 2022-03-08 /pmc/articles/PMC8958005/ /pubmed/35350181 http://dx.doi.org/10.3389/fbioe.2022.861950 Text en Copyright © 2022 Dong, Qian, Cui, Zheng, Cheng, Cao, Xu, Wang, Chen and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Dong, Hao
Qian, Libin
Cui, Yaoxuan
Zheng, Xubin
Cheng, Chen
Cao, Qingpeng
Xu, Feng
Wang, Jin
Chen, Xing
Wang, Di
Online Accurate Detection of Breath Acetone Using Metal Oxide Semiconductor Gas Sensor and Diffusive Gas Separation
title Online Accurate Detection of Breath Acetone Using Metal Oxide Semiconductor Gas Sensor and Diffusive Gas Separation
title_full Online Accurate Detection of Breath Acetone Using Metal Oxide Semiconductor Gas Sensor and Diffusive Gas Separation
title_fullStr Online Accurate Detection of Breath Acetone Using Metal Oxide Semiconductor Gas Sensor and Diffusive Gas Separation
title_full_unstemmed Online Accurate Detection of Breath Acetone Using Metal Oxide Semiconductor Gas Sensor and Diffusive Gas Separation
title_short Online Accurate Detection of Breath Acetone Using Metal Oxide Semiconductor Gas Sensor and Diffusive Gas Separation
title_sort online accurate detection of breath acetone using metal oxide semiconductor gas sensor and diffusive gas separation
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8958005/
https://www.ncbi.nlm.nih.gov/pubmed/35350181
http://dx.doi.org/10.3389/fbioe.2022.861950
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