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HDL Composition, Heart Failure, and Its Comorbidities
Although research on high-density lipoprotein (HDL) has historically focused on atherosclerotic coronary disease, there exists untapped potential of HDL biology for the treatment of heart failure. Anti-oxidant, anti-inflammatory, and endothelial protective properties of HDL could impact heart failur...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8958020/ https://www.ncbi.nlm.nih.gov/pubmed/35350538 http://dx.doi.org/10.3389/fcvm.2022.846990 |
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author | Diab, Ahmed Valenzuela Ripoll, Carla Guo, Zhen Javaheri, Ali |
author_facet | Diab, Ahmed Valenzuela Ripoll, Carla Guo, Zhen Javaheri, Ali |
author_sort | Diab, Ahmed |
collection | PubMed |
description | Although research on high-density lipoprotein (HDL) has historically focused on atherosclerotic coronary disease, there exists untapped potential of HDL biology for the treatment of heart failure. Anti-oxidant, anti-inflammatory, and endothelial protective properties of HDL could impact heart failure pathogenesis. HDL-associated proteins such as apolipoprotein A-I and M may have significant therapeutic effects on the myocardium, in part by modulating signal transduction pathways and sphingosine-1-phosphate biology. Furthermore, because heart failure is a complex syndrome characterized by multiple comorbidities, there are complex interactions between heart failure, its comorbidities, and lipoprotein homeostatic mechanisms. In this review, we will discuss the effects of heart failure and associated comorbidities on HDL, explore potential cardioprotective properties of HDL, and review novel HDL therapeutic targets in heart failure. |
format | Online Article Text |
id | pubmed-8958020 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-89580202022-03-28 HDL Composition, Heart Failure, and Its Comorbidities Diab, Ahmed Valenzuela Ripoll, Carla Guo, Zhen Javaheri, Ali Front Cardiovasc Med Cardiovascular Medicine Although research on high-density lipoprotein (HDL) has historically focused on atherosclerotic coronary disease, there exists untapped potential of HDL biology for the treatment of heart failure. Anti-oxidant, anti-inflammatory, and endothelial protective properties of HDL could impact heart failure pathogenesis. HDL-associated proteins such as apolipoprotein A-I and M may have significant therapeutic effects on the myocardium, in part by modulating signal transduction pathways and sphingosine-1-phosphate biology. Furthermore, because heart failure is a complex syndrome characterized by multiple comorbidities, there are complex interactions between heart failure, its comorbidities, and lipoprotein homeostatic mechanisms. In this review, we will discuss the effects of heart failure and associated comorbidities on HDL, explore potential cardioprotective properties of HDL, and review novel HDL therapeutic targets in heart failure. Frontiers Media S.A. 2022-03-08 /pmc/articles/PMC8958020/ /pubmed/35350538 http://dx.doi.org/10.3389/fcvm.2022.846990 Text en Copyright © 2022 Diab, Valenzuela Ripoll, Guo and Javaheri. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cardiovascular Medicine Diab, Ahmed Valenzuela Ripoll, Carla Guo, Zhen Javaheri, Ali HDL Composition, Heart Failure, and Its Comorbidities |
title | HDL Composition, Heart Failure, and Its Comorbidities |
title_full | HDL Composition, Heart Failure, and Its Comorbidities |
title_fullStr | HDL Composition, Heart Failure, and Its Comorbidities |
title_full_unstemmed | HDL Composition, Heart Failure, and Its Comorbidities |
title_short | HDL Composition, Heart Failure, and Its Comorbidities |
title_sort | hdl composition, heart failure, and its comorbidities |
topic | Cardiovascular Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8958020/ https://www.ncbi.nlm.nih.gov/pubmed/35350538 http://dx.doi.org/10.3389/fcvm.2022.846990 |
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