Cargando…

Testosterone Contributes to Vascular Dysfunction in Young Mice Fed a High Fat Diet by Promoting Nuclear Factor E2–Related Factor 2 Downregulation and Oxidative Stress

Obesity, an important risk factor for cardiovascular disease, promotes vascular oxidative stress. Considering that free testosterone levels remain within the reference range, especially in obese young men and that testosterone stimulates reactive oxygen species (ROS) generation, we sought to investi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Costa, Rafael M., Alves-Lopes, Rhéure, Alves, Juliano V., Servian, Carolina P., Mestriner, Fabíola L., Carneiro, Fernando S., Lobato, Núbia de S., Tostes, Rita C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Physiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8958040/ https://www.ncbi.nlm.nih.gov/pubmed/35350697 http://dx.doi.org/10.3389/fphys.2022.837603

Ejemplares similares

Testosterone and Vascular Function in Aging
por: Lopes, Rhéure A. M., et al.
Publicado: (2012)

Spironolactone treatment attenuates vascular dysfunction in type 2 diabetic mice by decreasing oxidative stress and restoring NO/GC signaling
por: Silva, Marcondes A. B., et al.
Publicado: (2015)

Perivascular Adipose Tissue as a Relevant Fat Depot for Cardiovascular Risk in Obesity
por: Costa, Rafael M., et al.
Publicado: (2018)

Supraphysiological Levels of Testosterone Induce Vascular Dysfunction via Activation of the NLRP3 Inflammasome
por: Alves, Juliano Vilela, et al.
Publicado: (2020)

Increased O-GlcNAcylation of Endothelial Nitric Oxide Synthase Compromises the Anti-contractile Properties of Perivascular Adipose Tissue in Metabolic Syndrome
por: da Costa, Rafael M., et al.
Publicado: (2018)

Acute Increase in O-GlcNAc Improves Survival in Mice With LPS-Induced Systemic Inflammatory Response Syndrome
por: Silva, Josiane Fernandes, et al.
Publicado: (2020)

Nrf2 as a Potential Mediator of Cardiovascular Risk in Metabolic Diseases
por: da Costa, Rafael M., et al.
Publicado: (2019)

TNF-α induces vascular insulin resistance via positive modulation of PTEN and decreased Akt/eNOS/NO signaling in high fat diet-fed mice
por: da Costa, Rafael Menezes, et al.
Publicado: (2016)

Differential Modulation of Nitric Oxide Synthases in Aging: Therapeutic Opportunities
por: Cau, Stefany B. A., et al.
Publicado: (2012)

Neuronal Inflammation is Associated with Changes in Epidermal Innervation in High Fat Fed Mice
por: Umbaugh, David S., et al.
Publicado: (2022)

Reduced Body Fat and Epididymal Adipose Apelin Expression Associated With Raspberry Ketone [4-(4-Hydroxyphenyl)-2-Butanone] Weight Gain Prevention in High-Fat-Diet Fed Mice
por: Hao, Lihong, et al.
Publicado: (2021)

Upregulation of Nrf2 and Decreased Redox Signaling Contribute to Renoprotective Effects of Chemerin Receptor Blockade in Diabetic Mice
por: Neves, Karla Bianca, et al.
Publicado: (2018)

Klotho Polymorphism in Association With Serum Testosterone and Knee Strength in Women After Testosterone Administration
por: Ekström, Lena, et al.
Publicado: (2022)

Intestinal Mucosal Triacylglycerol Accumulation Secondary to Decreased Lipid Secretion in Obese and High Fat Fed Mice
por: Douglass, John D., et al.
Publicado: (2012)

The Antioxidant Moiety of MitoQ Imparts Minimal Metabolic Effects in Adipose Tissue of High Fat Fed Mice
por: Bond, Simon T., et al.
Publicado: (2019)

3-Weeks of Exercise Training Increases Ischemic-Tolerance in Hearts From High-Fat Diet Fed Mice
por: Boardman, Neoma T., et al.
Publicado: (2019)

Links Between Testosterone, Oestrogen, and the Growth Hormone/Insulin-Like Growth Factor Axis and Resistance Exercise Muscle Adaptations
por: Gharahdaghi, Nima, et al.
Publicado: (2021)

The inflammasome NLRP3 plays a dual role on mouse corpora cavernosa relaxation
por: Fais, Rafael S., et al.
Publicado: (2019)

Author Correction: The inflammasome NLRP3 plays a dual role on mouse corpora cavernosa relaxation
por: Fais, Rafael S., et al.
Publicado: (2020)

SARS-CoV-2 Nucleocapsid Protein is Associated With Lower Testosterone Levels: An Experimental Study
por: Lucio Carrasco, Caio Henrique, et al.
Publicado: (2022)

Transplantation of Normal Adipose Tissue Improves Blood Flow and Reduces Inflammation in High Fat Fed Mice With Hindlimb Ischemia
por: Chen, Liyuan, et al.
Publicado: (2018)

Sex Differences in Metabolic and Behavioral Responses to Exercise but Not Exogenous Osteocalcin Treatment in Mice Fed a High Fat Diet
por: Winberg, Jordan, et al.
Publicado: (2022)

Functional and structural changes in internal pudendal arteries underlie erectile dysfunction induced by androgen deprivation
por: Alves-Lopes, Rhéure, et al.
Publicado: (2017)

Loss of Growth Differentiation Factor 11 Shortens Telomere Length by Downregulating Telomerase Activity
por: Wang, Di-Xian, et al.
Publicado: (2021)

Corrigendum: Transplantation of Normal Adipose Tissue Improves Blood Flow and Reduces Inflammation in High Fat Fed Mice With Hindlimb Ischemia
por: Chen, Liyuan, et al.
Publicado: (2018)

A Memory of Early Life Physical Activity Is Retained in Bone Marrow of Male Rats Fed a High-Fat Diet
por: Sontam, Dharani M., et al.
Publicado: (2017)

Central Administration of Insulin Combined With Resistin Reduces Renal Sympathetic Nerve Activity in Rats Fed a High Fat Diet
por: Habeeballah, Hamza, et al.
Publicado: (2019)

Constant-Moderate and High-Intensity Interval Training Have Differential Benefits on Insulin Sensitive Tissues in High-Fat Fed Mice
por: Martinez-Huenchullan, Sergio F., et al.
Publicado: (2019)

Dietary ketone ester attenuates the accretion of adiposity and liver steatosis in mice fed a high-fat, high-sugar diet
por: Rushing, Kelsey A., et al.
Publicado: (2023)

MicroRNAs as Factors in Bidirectional Crosstalk Between Mitochondria and the Nucleus During Cellular Senescence
por: Giordani, Chiara, et al.
Publicado: (2021)

Leptin and Melanocortin Signaling Mediates Hypertension in Offspring From Female Rabbits Fed a High-Fat Diet During Gestation and Lactation
por: Lim, Kyungjoon, et al.
Publicado: (2021)

Role of PARP and TRPM2 in VEGF Inhibitor‐Induced Vascular Dysfunction
por: Neves, Karla B., et al.
Publicado: (2023)

3,5-Diiodo-L-Thyronine Affects Structural and Metabolic Features of Skeletal Muscle Mitochondria in High-Fat-Diet Fed Rats Producing a Co-adaptation to the Glycolytic Fiber Phenotype
por: Silvestri, Elena, et al.
Publicado: (2018)

Acute/Chronic Responses of Combined Training on Serum Pro-thermogenic/Anti-inflammatory Inducers and Its Relation With Fed and Fasting State in Overweight Type 2 Diabetic Individuals
por: Bonfante, Ivan Luiz Padilha, et al.
Publicado: (2022)

Arterial Stiffening in Western Diet-Fed Mice Is Associated with Increased Vascular Elastin, Transforming Growth Factor-β, and Plasma Neuraminidase
por: Foote, Christopher A., et al.
Publicado: (2016)

Hydroxytyrosol-rich extract from olive juice as an additive in gilthead sea bream juveniles fed a high-fat diet: Regulation of somatic growth
por: Balbuena-Pecino, Sara, et al.
Publicado: (2022)

mTOR Inhibition: A Promise for a Young Heart
por: Cau, Stefany B. A., et al.
Publicado: (2012)

Android Fat Deposition and Its Association With Cardiovascular Risk Factors in Overweight Young Males
por: Sari, Carolina Ika, et al.
Publicado: (2019)

A Novel Hypothalamic Factor, Neurosecretory Protein GM, Causes Fat Deposition in Chicks
por: Kato, Masaki, et al.
Publicado: (2021)

p62/Sqstm1 rescue in muscle retards the progression of steatohepatitis in p62/Sqstm1-null mice fed a high-fat diet
por: Miura, Ikuru, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_qdoirau91se1unr20ap38j41t6