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Regulation of cardiac ryanodine receptor function by the cyclic-GMP dependent protein kinase G

BACKGROUND: The cGMP-dependent protein kinase G (PKG) phosphorylates the cardiac ryanodine receptor (RyR2) in vitro. We aimed to determine whether modulation of endogenous PKG alters RyR2-mediated spontaneous Ca(2+) release and whether this effect is linked to a change in RyR2 phosphorylation. METHO...

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Detalles Bibliográficos
Autores principales:	Gonano, Luis A., Aitken-Buck, Hamish M., Chakraborty, Akash D., Worthington, Luke P.I., Cully, Tanya R., Lamberts, Regis R., Vila-Petroff, Martin G., Jones, Peter P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8958330/ https://www.ncbi.nlm.nih.gov/pubmed/35356048 http://dx.doi.org/10.1016/j.crphys.2022.03.004

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