Chromosomal instability drives convergent and divergent evolution toward advantageous inherited traits in mammalian CHO bioproduction lineages

Genetic instability of Chinese hamster ovary (CHO) cells is implicated in production inconsistency through poorly defined mechanisms. Using a multi-omics approach, we analyzed the variations of CHO lineages derived from CHO-K1 cells. We identify an equilibrium between random genetic variation of the...

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Detalles Bibliográficos
Autores principales: Huhn, Steve, Chang, Meiping, Kumar, Amit, Liu, Ren, Jiang, Bo, Betenbaugh, Michael, Lin, Henry, Nyberg, Gregg, Du, Zhimei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8958363/
https://www.ncbi.nlm.nih.gov/pubmed/35355517
http://dx.doi.org/10.1016/j.isci.2022.104074

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