Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens

[Image: see text] TNP-2198, a stable conjugate of a rifamycin pharmacophore and a nitroimidazole pharmacophore, has been designed, synthesized, and evaluated as a novel dual-targeted antibacterial agent for the treatment of microaerophilic and anaerobic bacterial infections. TNP-2198 exhibits greate...

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Detalles Bibliográficos
Autores principales: Ma, Zhenkun, He, Shijie, Yuan, Ying, Zhuang, Zhijun, Liu, Yu, Wang, Huan, Chen, Jing, Xu, Xiangyi, Ding, Charles, Molodtsov, Vadim, Lin, Wei, Robertson, Gregory T., Weiss, William J., Pulse, Mark, Nguyen, Phung, Duncan, Leonard, Doyle, Timothy, Ebright, Richard H., Lynch, Anthony Simon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8958509/
https://www.ncbi.nlm.nih.gov/pubmed/35175750
http://dx.doi.org/10.1021/acs.jmedchem.1c02045

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