Discovery and In Vivo Proof of Concept of a Highly Potent Dual Inhibitor of Soluble Epoxide Hydrolase and Acetylcholinesterase for the Treatment of Alzheimer’s Disease

[Image: see text] With innumerable clinical failures of target-specific drug candidates for multifactorial diseases, such as Alzheimer’s disease (AD), which remains inefficiently treated, the advent of multitarget drug discovery has brought a new breath of hope. Here, we disclose a class of 6-chloro...

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Detalles Bibliográficos
Autores principales: Codony, Sandra, Pont, Caterina, Griñán-Ferré, Christian, Di Pede-Mattatelli, Ania, Calvó-Tusell, Carla, Feixas, Ferran, Osuna, Sílvia, Jarné-Ferrer, Júlia, Naldi, Marina, Bartolini, Manuela, Loza, María Isabel, Brea, José, Pérez, Belén, Bartra, Clara, Sanfeliu, Coral, Juárez-Jiménez, Jordi, Morisseau, Christophe, Hammock, Bruce D., Pallàs, Mercè, Vázquez, Santiago, Muñoz-Torrero, Diego
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8958510/
https://www.ncbi.nlm.nih.gov/pubmed/35271276
http://dx.doi.org/10.1021/acs.jmedchem.1c02150

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