Severe Vulvar and Perianal Crohn's Disease: A Case Report and Review of the Literature

Association of vulvar Crohn's disease (CD) with pyoderma gangrenosum (PG) has been described, yet due to its low prevalence, data on therapeutic management of this association are still limited. We here present a 22-year-old woman with severe vulvar and perianal CD with a major inguinal and per...

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Autores principales: Le Cosquer, Guillaume, Barranca, Alexis, Lapotre, Louise, Casassa, Eline, Chaput, Benoit, Ciron, Jonathan, Buscail, Louis, Paul, Carle, Gilletta, Cyrielle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2022
Materias:
Case and Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8958583/
https://www.ncbi.nlm.nih.gov/pubmed/35431854
http://dx.doi.org/10.1159/000522033
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author Le Cosquer, Guillaume
Barranca, Alexis
Lapotre, Louise
Casassa, Eline
Chaput, Benoit
Ciron, Jonathan
Buscail, Louis
Paul, Carle
Gilletta, Cyrielle
author_facet Le Cosquer, Guillaume
Barranca, Alexis
Lapotre, Louise
Casassa, Eline
Chaput, Benoit
Ciron, Jonathan
Buscail, Louis
Paul, Carle
Gilletta, Cyrielle
author_sort Le Cosquer, Guillaume
collection PubMed
description Association of vulvar Crohn's disease (CD) with pyoderma gangrenosum (PG) has been described, yet due to its low prevalence, data on therapeutic management of this association are still limited. We here present a 22-year-old woman with severe vulvar and perianal CD with a major inguinal and perineal ulceration. In the hypothesis of an associated PG, oral corticosteroids were prescribed at a dose of 40 mg with limited efficacy for a duration of 3 months. Afterward, a combination treatment of cyclosporine and infliximab followed by negative pressure wound therapy and split-thickness skin graft resulted in complete healing.
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spelling pubmed-89585832022-04-14 Severe Vulvar and Perianal Crohn's Disease: A Case Report and Review of the Literature Le Cosquer, Guillaume Barranca, Alexis Lapotre, Louise Casassa, Eline Chaput, Benoit Ciron, Jonathan Buscail, Louis Paul, Carle Gilletta, Cyrielle Case Rep Dermatol Case and Review Association of vulvar Crohn's disease (CD) with pyoderma gangrenosum (PG) has been described, yet due to its low prevalence, data on therapeutic management of this association are still limited. We here present a 22-year-old woman with severe vulvar and perianal CD with a major inguinal and perineal ulceration. In the hypothesis of an associated PG, oral corticosteroids were prescribed at a dose of 40 mg with limited efficacy for a duration of 3 months. Afterward, a combination treatment of cyclosporine and infliximab followed by negative pressure wound therapy and split-thickness skin graft resulted in complete healing. S. Karger AG 2022-03-01 /pmc/articles/PMC8958583/ /pubmed/35431854 http://dx.doi.org/10.1159/000522033 Text en Copyright © 2022 by S. Karger AG, Basel https://creativecommons.org/licenses/by-nc/4.0/This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Case and Review
Le Cosquer, Guillaume
Barranca, Alexis
Lapotre, Louise
Casassa, Eline
Chaput, Benoit
Ciron, Jonathan
Buscail, Louis
Paul, Carle
Gilletta, Cyrielle
Severe Vulvar and Perianal Crohn's Disease: A Case Report and Review of the Literature
title Severe Vulvar and Perianal Crohn's Disease: A Case Report and Review of the Literature
title_full Severe Vulvar and Perianal Crohn's Disease: A Case Report and Review of the Literature
title_fullStr Severe Vulvar and Perianal Crohn's Disease: A Case Report and Review of the Literature
title_full_unstemmed Severe Vulvar and Perianal Crohn's Disease: A Case Report and Review of the Literature
title_short Severe Vulvar and Perianal Crohn's Disease: A Case Report and Review of the Literature
title_sort severe vulvar and perianal crohn's disease: a case report and review of the literature
topic Case and Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8958583/
https://www.ncbi.nlm.nih.gov/pubmed/35431854
http://dx.doi.org/10.1159/000522033
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