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Targeting non-canonical pathways as a strategy to modulate the sodium iodide symporter

The sodium iodide symporter (NIS) functions to transport iodide and is critical for successful radioiodide ablation of cancer cells. Approaches to bolster NIS function and diminish recurrence post-radioiodide therapy are impeded by oncogenic pathways that suppress NIS, as well as the inherent comple...

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Detalles Bibliográficos
Autores principales: Read, Martin L., Brookes, Katie, Thornton, Caitlin E.M., Fletcher, Alice, Nieto, Hannah R., Alshahrani, Mohammed, Khan, Rashida, Borges de Souza, Patricia, Zha, Ling, Webster, Jamie R.M., Alderwick, Luke J., Campbell, Moray J., Boelaert, Kristien, Smith, Vicki E., McCabe, Christopher J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8958605/
https://www.ncbi.nlm.nih.gov/pubmed/34520744
http://dx.doi.org/10.1016/j.chembiol.2021.07.016