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Recent advance in treatment of atherosclerosis: Key targets and plaque-positioned delivery strategies

Atherosclerosis, a chronic inflammatory disease of vascular wall, is a progressive pathophysiological process with lipids oxidation/depositing initiation and innate/adaptive immune responses. The coordination of multi systems covering oxidative stress, dysfunctional endothelium, diseased lipid uptak...

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Detalles Bibliográficos
Autores principales: Li, Li, Liu, Sainan, Tan, Jianying, Wei, Lai, Wu, Dimeng, Gao, Shuai, Weng, Yajun, Chen, Junying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8958685/
https://www.ncbi.nlm.nih.gov/pubmed/35356091
http://dx.doi.org/10.1177/20417314221088509
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author Li, Li
Liu, Sainan
Tan, Jianying
Wei, Lai
Wu, Dimeng
Gao, Shuai
Weng, Yajun
Chen, Junying
author_facet Li, Li
Liu, Sainan
Tan, Jianying
Wei, Lai
Wu, Dimeng
Gao, Shuai
Weng, Yajun
Chen, Junying
author_sort Li, Li
collection PubMed
description Atherosclerosis, a chronic inflammatory disease of vascular wall, is a progressive pathophysiological process with lipids oxidation/depositing initiation and innate/adaptive immune responses. The coordination of multi systems covering oxidative stress, dysfunctional endothelium, diseased lipid uptake, cell apoptosis, thrombotic and pro-inflammatory responding as well as switched SMCs contributes to plaque growth. In this circumstance, inevitably, targeting these processes is considered to be effective for treating atherosclerosis. Arriving, retention and working of payload candidates mediated by targets in lesion direct ultimate therapeutic outcomes. Accumulating a series of scientific studies and clinical practice in the past decades, lesion homing delivery strategies including stent/balloon/nanoparticle-based transportation worked as the potent promotor to ensure a therapeutic effect. The objective of this review is to achieve a very brief summary about the effective therapeutic methods cooperating specifical targets and positioning-delivery strategies in atherosclerosis for better outcomes.
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spelling pubmed-89586852022-03-29 Recent advance in treatment of atherosclerosis: Key targets and plaque-positioned delivery strategies Li, Li Liu, Sainan Tan, Jianying Wei, Lai Wu, Dimeng Gao, Shuai Weng, Yajun Chen, Junying J Tissue Eng Controlling Cells for Tissue Repair Atherosclerosis, a chronic inflammatory disease of vascular wall, is a progressive pathophysiological process with lipids oxidation/depositing initiation and innate/adaptive immune responses. The coordination of multi systems covering oxidative stress, dysfunctional endothelium, diseased lipid uptake, cell apoptosis, thrombotic and pro-inflammatory responding as well as switched SMCs contributes to plaque growth. In this circumstance, inevitably, targeting these processes is considered to be effective for treating atherosclerosis. Arriving, retention and working of payload candidates mediated by targets in lesion direct ultimate therapeutic outcomes. Accumulating a series of scientific studies and clinical practice in the past decades, lesion homing delivery strategies including stent/balloon/nanoparticle-based transportation worked as the potent promotor to ensure a therapeutic effect. The objective of this review is to achieve a very brief summary about the effective therapeutic methods cooperating specifical targets and positioning-delivery strategies in atherosclerosis for better outcomes. SAGE Publications 2022-03-24 /pmc/articles/PMC8958685/ /pubmed/35356091 http://dx.doi.org/10.1177/20417314221088509 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Controlling Cells for Tissue Repair
Li, Li
Liu, Sainan
Tan, Jianying
Wei, Lai
Wu, Dimeng
Gao, Shuai
Weng, Yajun
Chen, Junying
Recent advance in treatment of atherosclerosis: Key targets and plaque-positioned delivery strategies
title Recent advance in treatment of atherosclerosis: Key targets and plaque-positioned delivery strategies
title_full Recent advance in treatment of atherosclerosis: Key targets and plaque-positioned delivery strategies
title_fullStr Recent advance in treatment of atherosclerosis: Key targets and plaque-positioned delivery strategies
title_full_unstemmed Recent advance in treatment of atherosclerosis: Key targets and plaque-positioned delivery strategies
title_short Recent advance in treatment of atherosclerosis: Key targets and plaque-positioned delivery strategies
title_sort recent advance in treatment of atherosclerosis: key targets and plaque-positioned delivery strategies
topic Controlling Cells for Tissue Repair
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8958685/
https://www.ncbi.nlm.nih.gov/pubmed/35356091
http://dx.doi.org/10.1177/20417314221088509
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