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Preoperative acute lung injury and oxygenation impairment occurred in the patients with acute aortic dissection
Acute lung injury (ALI) and oxygenation impairment (OI) frequently occur in the patients with acute aortic dissection (AAD), which may necessitate mechanical ventilation and result in adverse outcomes. This paper aims to increase clinicians’ awareness of the severe respiratory complications in the p...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8958762/ https://www.ncbi.nlm.nih.gov/pubmed/35346059 http://dx.doi.org/10.1186/s12872-022-02579-9 |
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author | Zhao, Xuemin Bie, Mengjun |
author_facet | Zhao, Xuemin Bie, Mengjun |
author_sort | Zhao, Xuemin |
collection | PubMed |
description | Acute lung injury (ALI) and oxygenation impairment (OI) frequently occur in the patients with acute aortic dissection (AAD), which may necessitate mechanical ventilation and result in adverse outcomes. This paper aims to increase clinicians’ awareness of the severe respiratory complications in the patients with AAD, and provide the overview of the epidemiology, adverse outcomes, pathogenesis, predictive markers and therapeutic modalities of the concurrent conditions. Currently, it is considered that inflammatory response plays a great role in the pathogenesis of ALI and OI in the patients with AAD, but the definite pathogenesis remains unclear. Given the great importance of the prediction of the occurrence of the severe respiratory complication at a very early stage, some inflammatory biomarkers have been investigated to predict the occurrence of ALI and OI in several studies. C-reactive protein was found to have a significant predictive effect for the development of ALI and OI. Early use of beta-blockers and the use of bindarit could prevent the occurrence of OI and ALI. Ulinastatin could also improve oxygenation in the patients with type-A AAD. Prevention and management of ALI and OI in AAD remain a great challenge. The definite pathogenesis should be clearly clarified and further studies should be performed to look for potential effective way to predict and manage the severe respiratory conditions. |
format | Online Article Text |
id | pubmed-8958762 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-89587622022-03-29 Preoperative acute lung injury and oxygenation impairment occurred in the patients with acute aortic dissection Zhao, Xuemin Bie, Mengjun BMC Cardiovasc Disord Review Acute lung injury (ALI) and oxygenation impairment (OI) frequently occur in the patients with acute aortic dissection (AAD), which may necessitate mechanical ventilation and result in adverse outcomes. This paper aims to increase clinicians’ awareness of the severe respiratory complications in the patients with AAD, and provide the overview of the epidemiology, adverse outcomes, pathogenesis, predictive markers and therapeutic modalities of the concurrent conditions. Currently, it is considered that inflammatory response plays a great role in the pathogenesis of ALI and OI in the patients with AAD, but the definite pathogenesis remains unclear. Given the great importance of the prediction of the occurrence of the severe respiratory complication at a very early stage, some inflammatory biomarkers have been investigated to predict the occurrence of ALI and OI in several studies. C-reactive protein was found to have a significant predictive effect for the development of ALI and OI. Early use of beta-blockers and the use of bindarit could prevent the occurrence of OI and ALI. Ulinastatin could also improve oxygenation in the patients with type-A AAD. Prevention and management of ALI and OI in AAD remain a great challenge. The definite pathogenesis should be clearly clarified and further studies should be performed to look for potential effective way to predict and manage the severe respiratory conditions. BioMed Central 2022-03-27 /pmc/articles/PMC8958762/ /pubmed/35346059 http://dx.doi.org/10.1186/s12872-022-02579-9 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Review Zhao, Xuemin Bie, Mengjun Preoperative acute lung injury and oxygenation impairment occurred in the patients with acute aortic dissection |
title | Preoperative acute lung injury and oxygenation impairment occurred in the patients with acute aortic dissection |
title_full | Preoperative acute lung injury and oxygenation impairment occurred in the patients with acute aortic dissection |
title_fullStr | Preoperative acute lung injury and oxygenation impairment occurred in the patients with acute aortic dissection |
title_full_unstemmed | Preoperative acute lung injury and oxygenation impairment occurred in the patients with acute aortic dissection |
title_short | Preoperative acute lung injury and oxygenation impairment occurred in the patients with acute aortic dissection |
title_sort | preoperative acute lung injury and oxygenation impairment occurred in the patients with acute aortic dissection |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8958762/ https://www.ncbi.nlm.nih.gov/pubmed/35346059 http://dx.doi.org/10.1186/s12872-022-02579-9 |
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