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Synthesis of metal anthranilate complexes: catalytic and antipathogenic studies
BACKGROUND: Anthranilic acid is an active compound with diverse biological activities such as anti-inflammatory, antineoplastic, anti-malarial and α-glucosidase inhibitory properties. It can also chelate transition metals to form complexes with applications as antipathogens, photoluminescent materia...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8958793/ https://www.ncbi.nlm.nih.gov/pubmed/35346333 http://dx.doi.org/10.1186/s13065-022-00817-x |
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author | Nawaz, Muhammad Abbasi, Muhammad Waseem Tariq, Marium Graham, John Patrick Al-Hagri, Abdul-Rahman Saleh Elkarim, Ahmed Awad Mohamed, Muayad Elsiddig Nissapatorn, Veeranoot Taha, Muhammad Hisaindee, Soleiman |
author_facet | Nawaz, Muhammad Abbasi, Muhammad Waseem Tariq, Marium Graham, John Patrick Al-Hagri, Abdul-Rahman Saleh Elkarim, Ahmed Awad Mohamed, Muayad Elsiddig Nissapatorn, Veeranoot Taha, Muhammad Hisaindee, Soleiman |
author_sort | Nawaz, Muhammad |
collection | PubMed |
description | BACKGROUND: Anthranilic acid is an active compound with diverse biological activities such as anti-inflammatory, antineoplastic, anti-malarial and α-glucosidase inhibitory properties. It can also chelate transition metals to form complexes with applications as antipathogens, photoluminescent materials, corrosion inhibitors, and catalysts. RESULTS: Anthranilic acid complexes (1–10) of Zn(II), Bi(III), Ag(I), Fe(II), Co(II), Cu(II), Mn(II), Al, Ni(II), and Cr(III) were synthesized and characterized using thermogravimetric (TGA), elemental analysis, FT-IR, UV–vis spectrometry, mass spectrometry and magnetic susceptibility. The morphology and size of metal complex (1–10) particles were determined by scanning electron microscope (SEM) and the surface area was determined by BET analysis. TGA and CHN analysis data indicated that the stoichiometries of complexes were 1:2 metal/ligand except for Ag(I), Al and Bi. Furthermore, DFT study was performed to optimize the structure of selected complexes. The complexes (1–10) were evaluated for their catalytic activity in the reduction of 4-nitrophenol (4-NP), antibacterial activity against S. aureus, P. aeroginosa and E. coli as well as their antifungal activity against F. solani and A. niger. The complexes were also tested against the second-stage juveniles (J(2)) root-knot nematodes. CONCLUSION: Co(II) complex 5 and Cu(II) complex 6 showed high catalytic activity for the reduction of 4-NP to 4-aminophenol (4-AP). Ag(I) complex 3 showed the best activity against the pathogens that were tested namely clinically important bacteria S. aureus, P. aeroginosa and E. coli, commercially important fungi F. solani and A. niger and J(2) root-knot nematodes M. javanica. |
format | Online Article Text |
id | pubmed-8958793 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-89587932022-03-29 Synthesis of metal anthranilate complexes: catalytic and antipathogenic studies Nawaz, Muhammad Abbasi, Muhammad Waseem Tariq, Marium Graham, John Patrick Al-Hagri, Abdul-Rahman Saleh Elkarim, Ahmed Awad Mohamed, Muayad Elsiddig Nissapatorn, Veeranoot Taha, Muhammad Hisaindee, Soleiman BMC Chem Research Article BACKGROUND: Anthranilic acid is an active compound with diverse biological activities such as anti-inflammatory, antineoplastic, anti-malarial and α-glucosidase inhibitory properties. It can also chelate transition metals to form complexes with applications as antipathogens, photoluminescent materials, corrosion inhibitors, and catalysts. RESULTS: Anthranilic acid complexes (1–10) of Zn(II), Bi(III), Ag(I), Fe(II), Co(II), Cu(II), Mn(II), Al, Ni(II), and Cr(III) were synthesized and characterized using thermogravimetric (TGA), elemental analysis, FT-IR, UV–vis spectrometry, mass spectrometry and magnetic susceptibility. The morphology and size of metal complex (1–10) particles were determined by scanning electron microscope (SEM) and the surface area was determined by BET analysis. TGA and CHN analysis data indicated that the stoichiometries of complexes were 1:2 metal/ligand except for Ag(I), Al and Bi. Furthermore, DFT study was performed to optimize the structure of selected complexes. The complexes (1–10) were evaluated for their catalytic activity in the reduction of 4-nitrophenol (4-NP), antibacterial activity against S. aureus, P. aeroginosa and E. coli as well as their antifungal activity against F. solani and A. niger. The complexes were also tested against the second-stage juveniles (J(2)) root-knot nematodes. CONCLUSION: Co(II) complex 5 and Cu(II) complex 6 showed high catalytic activity for the reduction of 4-NP to 4-aminophenol (4-AP). Ag(I) complex 3 showed the best activity against the pathogens that were tested namely clinically important bacteria S. aureus, P. aeroginosa and E. coli, commercially important fungi F. solani and A. niger and J(2) root-knot nematodes M. javanica. Springer International Publishing 2022-03-27 /pmc/articles/PMC8958793/ /pubmed/35346333 http://dx.doi.org/10.1186/s13065-022-00817-x Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Article Nawaz, Muhammad Abbasi, Muhammad Waseem Tariq, Marium Graham, John Patrick Al-Hagri, Abdul-Rahman Saleh Elkarim, Ahmed Awad Mohamed, Muayad Elsiddig Nissapatorn, Veeranoot Taha, Muhammad Hisaindee, Soleiman Synthesis of metal anthranilate complexes: catalytic and antipathogenic studies |
title | Synthesis of metal anthranilate complexes: catalytic and antipathogenic studies |
title_full | Synthesis of metal anthranilate complexes: catalytic and antipathogenic studies |
title_fullStr | Synthesis of metal anthranilate complexes: catalytic and antipathogenic studies |
title_full_unstemmed | Synthesis of metal anthranilate complexes: catalytic and antipathogenic studies |
title_short | Synthesis of metal anthranilate complexes: catalytic and antipathogenic studies |
title_sort | synthesis of metal anthranilate complexes: catalytic and antipathogenic studies |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8958793/ https://www.ncbi.nlm.nih.gov/pubmed/35346333 http://dx.doi.org/10.1186/s13065-022-00817-x |
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