Focused evaluation of the roles of macrophages in chimeric antigen receptor (CAR) T cell therapy associated cytokine release syndrome

Cytokine release syndrome (CRS) is a major obstacle to the widespread clinical application of chimeric antigen receptor (CAR) T cell therapies. CRS can also be induced by infections (such as SARS-CoV-2), drugs (such as therapeutic antibodies), and some autoimmune diseases. Myeloid-derived macrophage...

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Autores principales: Guo, Hanfei, Qian, Lei, Cui, Jiuwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Compuscript 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8958886/
https://www.ncbi.nlm.nih.gov/pubmed/34570442
http://dx.doi.org/10.20892/j.issn.2095-3941.2021.0087
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author Guo, Hanfei
Qian, Lei
Cui, Jiuwei
author_facet Guo, Hanfei
Qian, Lei
Cui, Jiuwei
author_sort Guo, Hanfei
collection PubMed
description Cytokine release syndrome (CRS) is a major obstacle to the widespread clinical application of chimeric antigen receptor (CAR) T cell therapies. CRS can also be induced by infections (such as SARS-CoV-2), drugs (such as therapeutic antibodies), and some autoimmune diseases. Myeloid-derived macrophages play key roles in the pathogenesis of CRS, and participate in the production and release of the core CRS cytokines, including interleukin (IL)-1, IL-6, and interferon-γ. In this review, we summarize the roles of macrophages in CRS and discuss new developments in macrophage activation and the related mechanisms of cytokine regulation in CRS.
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spelling pubmed-89588862022-04-08 Focused evaluation of the roles of macrophages in chimeric antigen receptor (CAR) T cell therapy associated cytokine release syndrome Guo, Hanfei Qian, Lei Cui, Jiuwei Cancer Biol Med Review Cytokine release syndrome (CRS) is a major obstacle to the widespread clinical application of chimeric antigen receptor (CAR) T cell therapies. CRS can also be induced by infections (such as SARS-CoV-2), drugs (such as therapeutic antibodies), and some autoimmune diseases. Myeloid-derived macrophages play key roles in the pathogenesis of CRS, and participate in the production and release of the core CRS cytokines, including interleukin (IL)-1, IL-6, and interferon-γ. In this review, we summarize the roles of macrophages in CRS and discuss new developments in macrophage activation and the related mechanisms of cytokine regulation in CRS. Compuscript 2022-03-15 2021-09-28 /pmc/articles/PMC8958886/ /pubmed/34570442 http://dx.doi.org/10.20892/j.issn.2095-3941.2021.0087 Text en Copyright: © 2022, Cancer Biology & Medicine https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY) 4.0 (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.
spellingShingle Review
Guo, Hanfei
Qian, Lei
Cui, Jiuwei
Focused evaluation of the roles of macrophages in chimeric antigen receptor (CAR) T cell therapy associated cytokine release syndrome
title Focused evaluation of the roles of macrophages in chimeric antigen receptor (CAR) T cell therapy associated cytokine release syndrome
title_full Focused evaluation of the roles of macrophages in chimeric antigen receptor (CAR) T cell therapy associated cytokine release syndrome
title_fullStr Focused evaluation of the roles of macrophages in chimeric antigen receptor (CAR) T cell therapy associated cytokine release syndrome
title_full_unstemmed Focused evaluation of the roles of macrophages in chimeric antigen receptor (CAR) T cell therapy associated cytokine release syndrome
title_short Focused evaluation of the roles of macrophages in chimeric antigen receptor (CAR) T cell therapy associated cytokine release syndrome
title_sort focused evaluation of the roles of macrophages in chimeric antigen receptor (car) t cell therapy associated cytokine release syndrome
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8958886/
https://www.ncbi.nlm.nih.gov/pubmed/34570442
http://dx.doi.org/10.20892/j.issn.2095-3941.2021.0087
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AT cuijiuwei focusedevaluationoftherolesofmacrophagesinchimericantigenreceptorcartcelltherapyassociatedcytokinereleasesyndrome

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