A Diagnostic Enigma of Central Versus Nephrogenic Diabetes Insipidus: What Does the Value of Copeptin Signify?

Diabetes insipidus (DI) is a rare disease characterized by hypotonic urine output and polydipsia. We report the case of a 50-year-old male admitted for diabetic ketoacidosis (DKA) in an intensive care unit with sepsis and alcoholic pancreatitis who later developed DI. He had a high copeptin level of...

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Autores principales: Shrestha, Dhan B, Jasaraj, Ranjit B, Dhital, Roman, Georges, Esho, Havrylyan, Andriy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Endocrinology/Diabetes/Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8959102/
https://www.ncbi.nlm.nih.gov/pubmed/35371639
http://dx.doi.org/10.7759/cureus.22633
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author Shrestha, Dhan B
Jasaraj, Ranjit B
Dhital, Roman
Georges, Esho
Havrylyan, Andriy
author_facet Shrestha, Dhan B
Jasaraj, Ranjit B
Dhital, Roman
Georges, Esho
Havrylyan, Andriy
author_sort Shrestha, Dhan B
collection PubMed
description Diabetes insipidus (DI) is a rare disease characterized by hypotonic urine output and polydipsia. We report the case of a 50-year-old male admitted for diabetic ketoacidosis (DKA) in an intensive care unit with sepsis and alcoholic pancreatitis who later developed DI. He had a high copeptin level of >21.4 pmol/L, suggesting DI of nephrogenic origin. At presentation, he had DKA-associated osmotic diuresis. His later finding of elevated copeptin suggesting partial nephrogenic DI created a diagnostic enigma.
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spelling pubmed-89591022022-04-01 A Diagnostic Enigma of Central Versus Nephrogenic Diabetes Insipidus: What Does the Value of Copeptin Signify? Shrestha, Dhan B Jasaraj, Ranjit B Dhital, Roman Georges, Esho Havrylyan, Andriy Cureus Endocrinology/Diabetes/Metabolism Diabetes insipidus (DI) is a rare disease characterized by hypotonic urine output and polydipsia. We report the case of a 50-year-old male admitted for diabetic ketoacidosis (DKA) in an intensive care unit with sepsis and alcoholic pancreatitis who later developed DI. He had a high copeptin level of >21.4 pmol/L, suggesting DI of nephrogenic origin. At presentation, he had DKA-associated osmotic diuresis. His later finding of elevated copeptin suggesting partial nephrogenic DI created a diagnostic enigma. Cureus 2022-02-26 /pmc/articles/PMC8959102/ /pubmed/35371639 http://dx.doi.org/10.7759/cureus.22633 Text en Copyright © 2022, Shrestha et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Endocrinology/Diabetes/Metabolism
Shrestha, Dhan B
Jasaraj, Ranjit B
Dhital, Roman
Georges, Esho
Havrylyan, Andriy
A Diagnostic Enigma of Central Versus Nephrogenic Diabetes Insipidus: What Does the Value of Copeptin Signify?
title A Diagnostic Enigma of Central Versus Nephrogenic Diabetes Insipidus: What Does the Value of Copeptin Signify?
title_full A Diagnostic Enigma of Central Versus Nephrogenic Diabetes Insipidus: What Does the Value of Copeptin Signify?
title_fullStr A Diagnostic Enigma of Central Versus Nephrogenic Diabetes Insipidus: What Does the Value of Copeptin Signify?
title_full_unstemmed A Diagnostic Enigma of Central Versus Nephrogenic Diabetes Insipidus: What Does the Value of Copeptin Signify?
title_short A Diagnostic Enigma of Central Versus Nephrogenic Diabetes Insipidus: What Does the Value of Copeptin Signify?
title_sort diagnostic enigma of central versus nephrogenic diabetes insipidus: what does the value of copeptin signify?
topic Endocrinology/Diabetes/Metabolism
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8959102/
https://www.ncbi.nlm.nih.gov/pubmed/35371639
http://dx.doi.org/10.7759/cureus.22633
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