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Placental nutrient transporters adapt during persistent maternal hypoglycaemia in rats
Maternal malnutrition is associated with decreased nutrient transfer to the foetus, which may lead to foetal growth restriction, predisposing children to a variety of diseases. However, regulation of placental nutrient transfer during decreased nutrient availability is not fully understood. In the p...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8959168/ https://www.ncbi.nlm.nih.gov/pubmed/35344549 http://dx.doi.org/10.1371/journal.pone.0265988 |
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author | Jensen, Vivi F. H. Mølck, Anne-Marie Nowak, Jette Wohlfarth, Maria Nüsken, Eva Demozay, Damien Nüsken, Kai-Dietrich Bøgh, Ingrid B. |
author_facet | Jensen, Vivi F. H. Mølck, Anne-Marie Nowak, Jette Wohlfarth, Maria Nüsken, Eva Demozay, Damien Nüsken, Kai-Dietrich Bøgh, Ingrid B. |
author_sort | Jensen, Vivi F. H. |
collection | PubMed |
description | Maternal malnutrition is associated with decreased nutrient transfer to the foetus, which may lead to foetal growth restriction, predisposing children to a variety of diseases. However, regulation of placental nutrient transfer during decreased nutrient availability is not fully understood. In the present study, the aim was to investigate changes in levels of placental nutrient transporters accompanying maternal hypoglycaemia following different durations and stages of gestation in rats. Maternal hypoglycaemia was induced by insulin-infusion throughout gestation until gestation day (GD)20 or until end of organogenesis (GD17), with sacrifice on GD17 or GD20. Protein levels of placental glucose transporters GLUT1 (45/55 kDa isotypes) and GLUT3, amino acid transporters SNAT1 and SNAT2, and insulin receptor (InsR) were assessed. On GD17, GLUT1-45, GLUT3, and SNAT1 levels were increased and InsR levels decreased versus controls. On GD20, following hypoglycaemia throughout gestation, GLUT3 levels were increased, GLUT1-55 showed the same trend. After cessation of hypoglycaemia at end of organogenesis, GLUT1-55, GLUT3, and InsR levels were increased versus controls, whereas SNAT1 levels were decreased. The increases in levels of placental nutrient transporters seen during maternal hypoglycaemia and hyperinsulinemia likely reflect an adaptive response to optimise foetal nutrient supply and development during limited availability of glucose. |
format | Online Article Text |
id | pubmed-8959168 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-89591682022-03-29 Placental nutrient transporters adapt during persistent maternal hypoglycaemia in rats Jensen, Vivi F. H. Mølck, Anne-Marie Nowak, Jette Wohlfarth, Maria Nüsken, Eva Demozay, Damien Nüsken, Kai-Dietrich Bøgh, Ingrid B. PLoS One Research Article Maternal malnutrition is associated with decreased nutrient transfer to the foetus, which may lead to foetal growth restriction, predisposing children to a variety of diseases. However, regulation of placental nutrient transfer during decreased nutrient availability is not fully understood. In the present study, the aim was to investigate changes in levels of placental nutrient transporters accompanying maternal hypoglycaemia following different durations and stages of gestation in rats. Maternal hypoglycaemia was induced by insulin-infusion throughout gestation until gestation day (GD)20 or until end of organogenesis (GD17), with sacrifice on GD17 or GD20. Protein levels of placental glucose transporters GLUT1 (45/55 kDa isotypes) and GLUT3, amino acid transporters SNAT1 and SNAT2, and insulin receptor (InsR) were assessed. On GD17, GLUT1-45, GLUT3, and SNAT1 levels were increased and InsR levels decreased versus controls. On GD20, following hypoglycaemia throughout gestation, GLUT3 levels were increased, GLUT1-55 showed the same trend. After cessation of hypoglycaemia at end of organogenesis, GLUT1-55, GLUT3, and InsR levels were increased versus controls, whereas SNAT1 levels were decreased. The increases in levels of placental nutrient transporters seen during maternal hypoglycaemia and hyperinsulinemia likely reflect an adaptive response to optimise foetal nutrient supply and development during limited availability of glucose. Public Library of Science 2022-03-28 /pmc/articles/PMC8959168/ /pubmed/35344549 http://dx.doi.org/10.1371/journal.pone.0265988 Text en © 2022 Jensen et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Jensen, Vivi F. H. Mølck, Anne-Marie Nowak, Jette Wohlfarth, Maria Nüsken, Eva Demozay, Damien Nüsken, Kai-Dietrich Bøgh, Ingrid B. Placental nutrient transporters adapt during persistent maternal hypoglycaemia in rats |
title | Placental nutrient transporters adapt during persistent maternal hypoglycaemia in rats |
title_full | Placental nutrient transporters adapt during persistent maternal hypoglycaemia in rats |
title_fullStr | Placental nutrient transporters adapt during persistent maternal hypoglycaemia in rats |
title_full_unstemmed | Placental nutrient transporters adapt during persistent maternal hypoglycaemia in rats |
title_short | Placental nutrient transporters adapt during persistent maternal hypoglycaemia in rats |
title_sort | placental nutrient transporters adapt during persistent maternal hypoglycaemia in rats |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8959168/ https://www.ncbi.nlm.nih.gov/pubmed/35344549 http://dx.doi.org/10.1371/journal.pone.0265988 |
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