Cargando…
Standard Clinical Screening Tests, Sural Radial Amplitude Ratio and F Wave Latency Compared to Conventional Nerve Conduction Studies in the Assessment of Sensorimotor Polyneuropathy in Patients with Type 2 Diabetes Mellitus
BACKGROUND AND AIMS: The measuring tools used for assessment of neuropathy include various questionnaires, monofilament testing, Biothesiometry and the gold standard test, nerve conduction studies (NCS). This study aims to evaluate the diagnostic accuracies of Michigan Neuropathy Screening Instrumen...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8959202/ https://www.ncbi.nlm.nih.gov/pubmed/35355904 http://dx.doi.org/10.4103/ijem.ijem_426_21 |
_version_ | 1784677098159341568 |
---|---|
author | Ramanathan, Saraswathi Thomas, Raji Chanu, Asem Rangita Naik, Dukhabandu Jebasingh, Felix Sivadasan, Ajit Thomas, Nihal |
author_facet | Ramanathan, Saraswathi Thomas, Raji Chanu, Asem Rangita Naik, Dukhabandu Jebasingh, Felix Sivadasan, Ajit Thomas, Nihal |
author_sort | Ramanathan, Saraswathi |
collection | PubMed |
description | BACKGROUND AND AIMS: The measuring tools used for assessment of neuropathy include various questionnaires, monofilament testing, Biothesiometry and the gold standard test, nerve conduction studies (NCS). This study aims to evaluate the diagnostic accuracies of Michigan Neuropathy Screening Instrument (MNSI), Biothesiometry, Semmes Weinstein Monofilament (SWMF), Sural Radial Amplitude Ratio (SRAR) and minimal F wave latency as compared to conventional NCS and arrive at a simple diagnostic algorithm for early detection of Diabetic Peripheral Neuropathy (DPN). METHODS: In a cross-sectional observational study on 48 Type 2 diabetes mellitus patients, MNSI, Biothesiometry, SWMF and NCS including F waves and SRAR were done and diagnostic accuracies (sensitivity, specificity, positive and negative predictive values) calculated taking NCS as gold standard. RESULTS: MNSI, Biothesiometry, SWMF, SRAR and minimal F wave latency had a sensitivity of 64.3%, 78.6%, 14.3%, 100% and 78.6% and specificity of 67.7%, 52.9%, 94.1%, 23.53% and 76.47% respectively, with reference to NCS. Based on combined sensitivities and specificities, we arrived at a simple algorithm for early diagnosis of DPN, which showed that DPN could either be diagnosed or ruled out in 75% of the patients by a combination of the Biothesiometry, SRAR and left lower limb minimal F wave latency results. CONCLUSIONS: In the setting of an outpatient, multidisciplinary diabetic clinic, simple tests such as questionnaires, monofilament testing and biosthesiometer could be performed with greater ease while considering NCS as the gold standard. This algorithm, combining Biothesiometry, SRAR and left lower limb minimal F wave latency would be less time consuming and help in early diagnosis of DPN. |
format | Online Article Text |
id | pubmed-8959202 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-89592022022-03-29 Standard Clinical Screening Tests, Sural Radial Amplitude Ratio and F Wave Latency Compared to Conventional Nerve Conduction Studies in the Assessment of Sensorimotor Polyneuropathy in Patients with Type 2 Diabetes Mellitus Ramanathan, Saraswathi Thomas, Raji Chanu, Asem Rangita Naik, Dukhabandu Jebasingh, Felix Sivadasan, Ajit Thomas, Nihal Indian J Endocrinol Metab Original Article BACKGROUND AND AIMS: The measuring tools used for assessment of neuropathy include various questionnaires, monofilament testing, Biothesiometry and the gold standard test, nerve conduction studies (NCS). This study aims to evaluate the diagnostic accuracies of Michigan Neuropathy Screening Instrument (MNSI), Biothesiometry, Semmes Weinstein Monofilament (SWMF), Sural Radial Amplitude Ratio (SRAR) and minimal F wave latency as compared to conventional NCS and arrive at a simple diagnostic algorithm for early detection of Diabetic Peripheral Neuropathy (DPN). METHODS: In a cross-sectional observational study on 48 Type 2 diabetes mellitus patients, MNSI, Biothesiometry, SWMF and NCS including F waves and SRAR were done and diagnostic accuracies (sensitivity, specificity, positive and negative predictive values) calculated taking NCS as gold standard. RESULTS: MNSI, Biothesiometry, SWMF, SRAR and minimal F wave latency had a sensitivity of 64.3%, 78.6%, 14.3%, 100% and 78.6% and specificity of 67.7%, 52.9%, 94.1%, 23.53% and 76.47% respectively, with reference to NCS. Based on combined sensitivities and specificities, we arrived at a simple algorithm for early diagnosis of DPN, which showed that DPN could either be diagnosed or ruled out in 75% of the patients by a combination of the Biothesiometry, SRAR and left lower limb minimal F wave latency results. CONCLUSIONS: In the setting of an outpatient, multidisciplinary diabetic clinic, simple tests such as questionnaires, monofilament testing and biosthesiometer could be performed with greater ease while considering NCS as the gold standard. This algorithm, combining Biothesiometry, SRAR and left lower limb minimal F wave latency would be less time consuming and help in early diagnosis of DPN. Wolters Kluwer - Medknow 2021 2022-02-17 /pmc/articles/PMC8959202/ /pubmed/35355904 http://dx.doi.org/10.4103/ijem.ijem_426_21 Text en Copyright: © 2022 Indian Journal of Endocrinology and Metabolism https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Ramanathan, Saraswathi Thomas, Raji Chanu, Asem Rangita Naik, Dukhabandu Jebasingh, Felix Sivadasan, Ajit Thomas, Nihal Standard Clinical Screening Tests, Sural Radial Amplitude Ratio and F Wave Latency Compared to Conventional Nerve Conduction Studies in the Assessment of Sensorimotor Polyneuropathy in Patients with Type 2 Diabetes Mellitus |
title | Standard Clinical Screening Tests, Sural Radial Amplitude Ratio and F Wave Latency Compared to Conventional Nerve Conduction Studies in the Assessment of Sensorimotor Polyneuropathy in Patients with Type 2 Diabetes Mellitus |
title_full | Standard Clinical Screening Tests, Sural Radial Amplitude Ratio and F Wave Latency Compared to Conventional Nerve Conduction Studies in the Assessment of Sensorimotor Polyneuropathy in Patients with Type 2 Diabetes Mellitus |
title_fullStr | Standard Clinical Screening Tests, Sural Radial Amplitude Ratio and F Wave Latency Compared to Conventional Nerve Conduction Studies in the Assessment of Sensorimotor Polyneuropathy in Patients with Type 2 Diabetes Mellitus |
title_full_unstemmed | Standard Clinical Screening Tests, Sural Radial Amplitude Ratio and F Wave Latency Compared to Conventional Nerve Conduction Studies in the Assessment of Sensorimotor Polyneuropathy in Patients with Type 2 Diabetes Mellitus |
title_short | Standard Clinical Screening Tests, Sural Radial Amplitude Ratio and F Wave Latency Compared to Conventional Nerve Conduction Studies in the Assessment of Sensorimotor Polyneuropathy in Patients with Type 2 Diabetes Mellitus |
title_sort | standard clinical screening tests, sural radial amplitude ratio and f wave latency compared to conventional nerve conduction studies in the assessment of sensorimotor polyneuropathy in patients with type 2 diabetes mellitus |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8959202/ https://www.ncbi.nlm.nih.gov/pubmed/35355904 http://dx.doi.org/10.4103/ijem.ijem_426_21 |
work_keys_str_mv | AT ramanathansaraswathi standardclinicalscreeningtestssuralradialamplituderatioandfwavelatencycomparedtoconventionalnerveconductionstudiesintheassessmentofsensorimotorpolyneuropathyinpatientswithtype2diabetesmellitus AT thomasraji standardclinicalscreeningtestssuralradialamplituderatioandfwavelatencycomparedtoconventionalnerveconductionstudiesintheassessmentofsensorimotorpolyneuropathyinpatientswithtype2diabetesmellitus AT chanuasemrangita standardclinicalscreeningtestssuralradialamplituderatioandfwavelatencycomparedtoconventionalnerveconductionstudiesintheassessmentofsensorimotorpolyneuropathyinpatientswithtype2diabetesmellitus AT naikdukhabandu standardclinicalscreeningtestssuralradialamplituderatioandfwavelatencycomparedtoconventionalnerveconductionstudiesintheassessmentofsensorimotorpolyneuropathyinpatientswithtype2diabetesmellitus AT jebasinghfelix standardclinicalscreeningtestssuralradialamplituderatioandfwavelatencycomparedtoconventionalnerveconductionstudiesintheassessmentofsensorimotorpolyneuropathyinpatientswithtype2diabetesmellitus AT sivadasanajit standardclinicalscreeningtestssuralradialamplituderatioandfwavelatencycomparedtoconventionalnerveconductionstudiesintheassessmentofsensorimotorpolyneuropathyinpatientswithtype2diabetesmellitus AT thomasnihal standardclinicalscreeningtestssuralradialamplituderatioandfwavelatencycomparedtoconventionalnerveconductionstudiesintheassessmentofsensorimotorpolyneuropathyinpatientswithtype2diabetesmellitus |