The Role of Apelin–APJ System in Diabetes and Obesity

Nowadays, diabetes and obesity are two main health-threatening metabolic disorders in the world, which increase the risk for many chronic diseases. Apelin, a peptide hormone, exerts its effect by binding with angiotensin II protein J receptor (APJ) and is considered to be linked with diabetes and ob...

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Autores principales: Li, Cheng, Cheng, Hongna, Adhikari, Binay Kumar, Wang, Shudong, Yang, Na, Liu, Wenyun, Sun, Jian, Wang, Yonggang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8959308/
https://www.ncbi.nlm.nih.gov/pubmed/35355561
http://dx.doi.org/10.3389/fendo.2022.820002
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author Li, Cheng
Cheng, Hongna
Adhikari, Binay Kumar
Wang, Shudong
Yang, Na
Liu, Wenyun
Sun, Jian
Wang, Yonggang
author_facet Li, Cheng
Cheng, Hongna
Adhikari, Binay Kumar
Wang, Shudong
Yang, Na
Liu, Wenyun
Sun, Jian
Wang, Yonggang
author_sort Li, Cheng
collection PubMed
description Nowadays, diabetes and obesity are two main health-threatening metabolic disorders in the world, which increase the risk for many chronic diseases. Apelin, a peptide hormone, exerts its effect by binding with angiotensin II protein J receptor (APJ) and is considered to be linked with diabetes and obesity. Apelin and its receptor are widely present in the body and are involved in many physiological processes, such as glucose and lipid metabolism, homeostasis, endocrine response to stress, and angiogenesis. In this review, we summarize the literatures on the role of the Apelin–APJ system in diabetes and obesity for a better understanding of the mechanism and function of apelin and its receptor in the pathophysiology of diseases that may contribute to the development of new therapies.
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spelling pubmed-89593082022-03-29 The Role of Apelin–APJ System in Diabetes and Obesity Li, Cheng Cheng, Hongna Adhikari, Binay Kumar Wang, Shudong Yang, Na Liu, Wenyun Sun, Jian Wang, Yonggang Front Endocrinol (Lausanne) Endocrinology Nowadays, diabetes and obesity are two main health-threatening metabolic disorders in the world, which increase the risk for many chronic diseases. Apelin, a peptide hormone, exerts its effect by binding with angiotensin II protein J receptor (APJ) and is considered to be linked with diabetes and obesity. Apelin and its receptor are widely present in the body and are involved in many physiological processes, such as glucose and lipid metabolism, homeostasis, endocrine response to stress, and angiogenesis. In this review, we summarize the literatures on the role of the Apelin–APJ system in diabetes and obesity for a better understanding of the mechanism and function of apelin and its receptor in the pathophysiology of diseases that may contribute to the development of new therapies. Frontiers Media S.A. 2022-03-09 /pmc/articles/PMC8959308/ /pubmed/35355561 http://dx.doi.org/10.3389/fendo.2022.820002 Text en Copyright © 2022 Li, Cheng, Adhikari, Wang, Yang, Liu, Sun and Wang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Li, Cheng
Cheng, Hongna
Adhikari, Binay Kumar
Wang, Shudong
Yang, Na
Liu, Wenyun
Sun, Jian
Wang, Yonggang
The Role of Apelin–APJ System in Diabetes and Obesity
title The Role of Apelin–APJ System in Diabetes and Obesity
title_full The Role of Apelin–APJ System in Diabetes and Obesity
title_fullStr The Role of Apelin–APJ System in Diabetes and Obesity
title_full_unstemmed The Role of Apelin–APJ System in Diabetes and Obesity
title_short The Role of Apelin–APJ System in Diabetes and Obesity
title_sort role of apelin–apj system in diabetes and obesity
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8959308/
https://www.ncbi.nlm.nih.gov/pubmed/35355561
http://dx.doi.org/10.3389/fendo.2022.820002
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