Cargando…

Cerebellar and Prefrontal Structures Associated With Executive Functioning in Pediatric Patients With Congenital Heart Defects

OBJECTIVE: Children, adolescents, and young adults with congenital heart defects (CHD) often display executive dysfunction. We consider the prefrontal and cerebellar brain structures as mechanisms for executive dysfunction among those with CHD. METHODS: 55 participants with CHD (M age = 13.93) and 9...

Descripción completa

Detalles Bibliográficos
Autores principales: Badaly, Daryaneh, Beers, Sue R., Ceschin, Rafael, Lee, Vincent K., Sulaiman, Shahida, Zahner, Alexandria, Wallace, Julia, Berdaa-Sahel, Aurélia, Burns, Cheryl, Lo, Cecilia W., Panigrahy, Ashok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8959311/
https://www.ncbi.nlm.nih.gov/pubmed/35356449
http://dx.doi.org/10.3389/fneur.2022.827780
_version_ 1784677124737597440
author Badaly, Daryaneh
Beers, Sue R.
Ceschin, Rafael
Lee, Vincent K.
Sulaiman, Shahida
Zahner, Alexandria
Wallace, Julia
Berdaa-Sahel, Aurélia
Burns, Cheryl
Lo, Cecilia W.
Panigrahy, Ashok
author_facet Badaly, Daryaneh
Beers, Sue R.
Ceschin, Rafael
Lee, Vincent K.
Sulaiman, Shahida
Zahner, Alexandria
Wallace, Julia
Berdaa-Sahel, Aurélia
Burns, Cheryl
Lo, Cecilia W.
Panigrahy, Ashok
author_sort Badaly, Daryaneh
collection PubMed
description OBJECTIVE: Children, adolescents, and young adults with congenital heart defects (CHD) often display executive dysfunction. We consider the prefrontal and cerebellar brain structures as mechanisms for executive dysfunction among those with CHD. METHODS: 55 participants with CHD (M age = 13.93) and 95 healthy controls (M age = 13.13) completed magnetic resonance imaging (MRI) of the brain, from which we extracted volumetric data on prefrontal and cerebellar regions. Participants also completed neuropsychological tests of executive functioning; their parents completed ratings of their executive functions. RESULTS: Compared to healthy controls, those with CHD had smaller cerebellums and lateral, medial, and orbital prefrontal regions, they performed more poorly on tests of working memory, inhibitory control, and mental flexibility, and their parents rated them as having poorer executive functions across several indices. Across both groups, there were significant correlations for cerebellar and/or prefrontal volumes with cognitive assessments of working memory, mental flexibility, and inhibitory control and with parent-completed ratings of task initiation, working memory, and planning/organization. Greater prefrontal volumes were associated with better working memory, among those with larger cerebellums (with group differences based on the measure and the prefrontal region). Greater prefrontal volumes were related to better emotional regulation only among participants with CHD with smaller cerebellar volumes, and with poorer inhibition and emotional regulation only among healthy controls with larger cerebellar volumes. CONCLUSION: The cerebellum not only contributes to executive functioning among young individuals with CHD but may also modulate the relationships between prefrontal regions and executive functioning differently for pediatric patients with CHD vs. health controls.
format Online
Article
Text
id pubmed-8959311
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-89593112022-03-29 Cerebellar and Prefrontal Structures Associated With Executive Functioning in Pediatric Patients With Congenital Heart Defects Badaly, Daryaneh Beers, Sue R. Ceschin, Rafael Lee, Vincent K. Sulaiman, Shahida Zahner, Alexandria Wallace, Julia Berdaa-Sahel, Aurélia Burns, Cheryl Lo, Cecilia W. Panigrahy, Ashok Front Neurol Neurology OBJECTIVE: Children, adolescents, and young adults with congenital heart defects (CHD) often display executive dysfunction. We consider the prefrontal and cerebellar brain structures as mechanisms for executive dysfunction among those with CHD. METHODS: 55 participants with CHD (M age = 13.93) and 95 healthy controls (M age = 13.13) completed magnetic resonance imaging (MRI) of the brain, from which we extracted volumetric data on prefrontal and cerebellar regions. Participants also completed neuropsychological tests of executive functioning; their parents completed ratings of their executive functions. RESULTS: Compared to healthy controls, those with CHD had smaller cerebellums and lateral, medial, and orbital prefrontal regions, they performed more poorly on tests of working memory, inhibitory control, and mental flexibility, and their parents rated them as having poorer executive functions across several indices. Across both groups, there were significant correlations for cerebellar and/or prefrontal volumes with cognitive assessments of working memory, mental flexibility, and inhibitory control and with parent-completed ratings of task initiation, working memory, and planning/organization. Greater prefrontal volumes were associated with better working memory, among those with larger cerebellums (with group differences based on the measure and the prefrontal region). Greater prefrontal volumes were related to better emotional regulation only among participants with CHD with smaller cerebellar volumes, and with poorer inhibition and emotional regulation only among healthy controls with larger cerebellar volumes. CONCLUSION: The cerebellum not only contributes to executive functioning among young individuals with CHD but may also modulate the relationships between prefrontal regions and executive functioning differently for pediatric patients with CHD vs. health controls. Frontiers Media S.A. 2022-03-09 /pmc/articles/PMC8959311/ /pubmed/35356449 http://dx.doi.org/10.3389/fneur.2022.827780 Text en Copyright © 2022 Badaly, Beers, Ceschin, Lee, Sulaiman, Zahner, Wallace, Berdaa-Sahel, Burns, Lo and Panigrahy. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Badaly, Daryaneh
Beers, Sue R.
Ceschin, Rafael
Lee, Vincent K.
Sulaiman, Shahida
Zahner, Alexandria
Wallace, Julia
Berdaa-Sahel, Aurélia
Burns, Cheryl
Lo, Cecilia W.
Panigrahy, Ashok
Cerebellar and Prefrontal Structures Associated With Executive Functioning in Pediatric Patients With Congenital Heart Defects
title Cerebellar and Prefrontal Structures Associated With Executive Functioning in Pediatric Patients With Congenital Heart Defects
title_full Cerebellar and Prefrontal Structures Associated With Executive Functioning in Pediatric Patients With Congenital Heart Defects
title_fullStr Cerebellar and Prefrontal Structures Associated With Executive Functioning in Pediatric Patients With Congenital Heart Defects
title_full_unstemmed Cerebellar and Prefrontal Structures Associated With Executive Functioning in Pediatric Patients With Congenital Heart Defects
title_short Cerebellar and Prefrontal Structures Associated With Executive Functioning in Pediatric Patients With Congenital Heart Defects
title_sort cerebellar and prefrontal structures associated with executive functioning in pediatric patients with congenital heart defects
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8959311/
https://www.ncbi.nlm.nih.gov/pubmed/35356449
http://dx.doi.org/10.3389/fneur.2022.827780
work_keys_str_mv AT badalydaryaneh cerebellarandprefrontalstructuresassociatedwithexecutivefunctioninginpediatricpatientswithcongenitalheartdefects
AT beerssuer cerebellarandprefrontalstructuresassociatedwithexecutivefunctioninginpediatricpatientswithcongenitalheartdefects
AT ceschinrafael cerebellarandprefrontalstructuresassociatedwithexecutivefunctioninginpediatricpatientswithcongenitalheartdefects
AT leevincentk cerebellarandprefrontalstructuresassociatedwithexecutivefunctioninginpediatricpatientswithcongenitalheartdefects
AT sulaimanshahida cerebellarandprefrontalstructuresassociatedwithexecutivefunctioninginpediatricpatientswithcongenitalheartdefects
AT zahneralexandria cerebellarandprefrontalstructuresassociatedwithexecutivefunctioninginpediatricpatientswithcongenitalheartdefects
AT wallacejulia cerebellarandprefrontalstructuresassociatedwithexecutivefunctioninginpediatricpatientswithcongenitalheartdefects
AT berdaasahelaurelia cerebellarandprefrontalstructuresassociatedwithexecutivefunctioninginpediatricpatientswithcongenitalheartdefects
AT burnscheryl cerebellarandprefrontalstructuresassociatedwithexecutivefunctioninginpediatricpatientswithcongenitalheartdefects
AT loceciliaw cerebellarandprefrontalstructuresassociatedwithexecutivefunctioninginpediatricpatientswithcongenitalheartdefects
AT panigrahyashok cerebellarandprefrontalstructuresassociatedwithexecutivefunctioninginpediatricpatientswithcongenitalheartdefects