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UGT1A1 Allele Test Not Only Minimizes the Toxicity But Also Maximizes the Therapeutic Effect of Irinotecan in the Treatment of Colorectal Cancer: A Narrative Review

BACKGROUND: Irinotecan is a first-line agent in the systematic treatment of colorectal cancer (CRC). Adjusting the dose of irinotecan according to the uridine diphosphate glucuronosyltransferase (UGT) 1A1 genotype reflects the principle of individualized and precision medicine, and may improve the c...

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Detalles Bibliográficos
Autores principales:	Li, Yaoyuan, Zheng, Honggang, Zhang, Xiwen, Xi, Yupeng, Cheng, Mengqi, Zhao, Yuwei, Wang, Liya, Hua, Baojin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8959381/ https://www.ncbi.nlm.nih.gov/pubmed/35356222 http://dx.doi.org/10.3389/fonc.2022.854478

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