Case Report: Management of Recurrent Ovarian Squamous Cell Carcinoma With PD-1 Inhibitor

Malignant transformations, such as ovarian squamous cell carcinoma (SCC) in ovarian mature cystic teratoma (OMCT), are rare tumors. The management of recurrent disease is still a challenge, and the gene mutations involved remain unclear. We herein report a recurrent case of ovarian SCC with a PIK3CA...

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Autores principales: Song, Xiao-chen, Wang, Yong-xue, Yu, Mei, Cao, Dong-yan, Yang, Jia-xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8959438/
https://www.ncbi.nlm.nih.gov/pubmed/35356229
http://dx.doi.org/10.3389/fonc.2022.789228
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author Song, Xiao-chen
Wang, Yong-xue
Yu, Mei
Cao, Dong-yan
Yang, Jia-xin
author_facet Song, Xiao-chen
Wang, Yong-xue
Yu, Mei
Cao, Dong-yan
Yang, Jia-xin
author_sort Song, Xiao-chen
collection PubMed
description Malignant transformations, such as ovarian squamous cell carcinoma (SCC) in ovarian mature cystic teratoma (OMCT), are rare tumors. The management of recurrent disease is still a challenge, and the gene mutations involved remain unclear. We herein report a recurrent case of ovarian SCC with a PIK3CA gene variation and immunohistochemical staining of programmed death-ligand 1 (PD-L1) >10%. This patient achieved clinical remission after platinum-based effective chemotherapy and programmed death 1 (PD-1) immunotherapy.
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spelling pubmed-89594382022-03-29 Case Report: Management of Recurrent Ovarian Squamous Cell Carcinoma With PD-1 Inhibitor Song, Xiao-chen Wang, Yong-xue Yu, Mei Cao, Dong-yan Yang, Jia-xin Front Oncol Oncology Malignant transformations, such as ovarian squamous cell carcinoma (SCC) in ovarian mature cystic teratoma (OMCT), are rare tumors. The management of recurrent disease is still a challenge, and the gene mutations involved remain unclear. We herein report a recurrent case of ovarian SCC with a PIK3CA gene variation and immunohistochemical staining of programmed death-ligand 1 (PD-L1) >10%. This patient achieved clinical remission after platinum-based effective chemotherapy and programmed death 1 (PD-1) immunotherapy. Frontiers Media S.A. 2022-03-09 /pmc/articles/PMC8959438/ /pubmed/35356229 http://dx.doi.org/10.3389/fonc.2022.789228 Text en Copyright © 2022 Song, Wang, Yu, Cao and Yang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Song, Xiao-chen
Wang, Yong-xue
Yu, Mei
Cao, Dong-yan
Yang, Jia-xin
Case Report: Management of Recurrent Ovarian Squamous Cell Carcinoma With PD-1 Inhibitor
title Case Report: Management of Recurrent Ovarian Squamous Cell Carcinoma With PD-1 Inhibitor
title_full Case Report: Management of Recurrent Ovarian Squamous Cell Carcinoma With PD-1 Inhibitor
title_fullStr Case Report: Management of Recurrent Ovarian Squamous Cell Carcinoma With PD-1 Inhibitor
title_full_unstemmed Case Report: Management of Recurrent Ovarian Squamous Cell Carcinoma With PD-1 Inhibitor
title_short Case Report: Management of Recurrent Ovarian Squamous Cell Carcinoma With PD-1 Inhibitor
title_sort case report: management of recurrent ovarian squamous cell carcinoma with pd-1 inhibitor
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8959438/
https://www.ncbi.nlm.nih.gov/pubmed/35356229
http://dx.doi.org/10.3389/fonc.2022.789228
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