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Deep sequencing of the HIV-1 polymerase gene for characterisation of cytotoxic T-lymphocyte epitopes during early and chronic disease stages

BACKGROUND: Despite multiple attempts, there is still no effective HIV-1 vaccine available. The HIV-1 polymerase (pol) gene is highly conserved and encodes cytotoxic T-lymphocyte (CTL) epitopes. The aim of the study was to characterise HIV-1 Pol CTL epitopes in mostly sample pairs obtained during ea...

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Detalles Bibliográficos
Autores principales:	Nkone, Paballo, Loubser, Shayne, Quinn, Thomas C., Redd, Andrew D., Ismail, Arshad, Tiemessen, Caroline T., Mayaphi, Simnikiwe H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8959563/ https://www.ncbi.nlm.nih.gov/pubmed/35346259 http://dx.doi.org/10.1186/s12985-022-01772-8

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