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Management of Motion and Anatomical Variations in Charged Particle Therapy: Past, Present, and Into the Future

The major aim of radiation therapy is to provide curative or palliative treatment to cancerous malignancies while minimizing damage to healthy tissues. Charged particle radiotherapy utilizing carbon ions or protons is uniquely suited for this task due to its ability to achieve highly conformal dose...

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Autores principales: Pakela, Julia M., Knopf, Antje, Dong, Lei, Rucinski, Antoni, Zou, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8959592/
https://www.ncbi.nlm.nih.gov/pubmed/35356213
http://dx.doi.org/10.3389/fonc.2022.806153
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author Pakela, Julia M.
Knopf, Antje
Dong, Lei
Rucinski, Antoni
Zou, Wei
author_facet Pakela, Julia M.
Knopf, Antje
Dong, Lei
Rucinski, Antoni
Zou, Wei
author_sort Pakela, Julia M.
collection PubMed
description The major aim of radiation therapy is to provide curative or palliative treatment to cancerous malignancies while minimizing damage to healthy tissues. Charged particle radiotherapy utilizing carbon ions or protons is uniquely suited for this task due to its ability to achieve highly conformal dose distributions around the tumor volume. For these treatment modalities, uncertainties in the localization of patient anatomy due to inter- and intra-fractional motion present a heightened risk of undesired dose delivery. A diverse range of mitigation strategies have been developed and clinically implemented in various disease sites to monitor and correct for patient motion, but much work remains. This review provides an overview of current clinical practices for inter and intra-fractional motion management in charged particle therapy, including motion control, current imaging and motion tracking modalities, as well as treatment planning and delivery techniques. We also cover progress to date on emerging technologies including particle-based radiography imaging, novel treatment delivery methods such as tumor tracking and FLASH, and artificial intelligence and discuss their potential impact towards improving or increasing the challenge of motion mitigation in charged particle therapy.
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spelling pubmed-89595922022-03-29 Management of Motion and Anatomical Variations in Charged Particle Therapy: Past, Present, and Into the Future Pakela, Julia M. Knopf, Antje Dong, Lei Rucinski, Antoni Zou, Wei Front Oncol Oncology The major aim of radiation therapy is to provide curative or palliative treatment to cancerous malignancies while minimizing damage to healthy tissues. Charged particle radiotherapy utilizing carbon ions or protons is uniquely suited for this task due to its ability to achieve highly conformal dose distributions around the tumor volume. For these treatment modalities, uncertainties in the localization of patient anatomy due to inter- and intra-fractional motion present a heightened risk of undesired dose delivery. A diverse range of mitigation strategies have been developed and clinically implemented in various disease sites to monitor and correct for patient motion, but much work remains. This review provides an overview of current clinical practices for inter and intra-fractional motion management in charged particle therapy, including motion control, current imaging and motion tracking modalities, as well as treatment planning and delivery techniques. We also cover progress to date on emerging technologies including particle-based radiography imaging, novel treatment delivery methods such as tumor tracking and FLASH, and artificial intelligence and discuss their potential impact towards improving or increasing the challenge of motion mitigation in charged particle therapy. Frontiers Media S.A. 2022-03-09 /pmc/articles/PMC8959592/ /pubmed/35356213 http://dx.doi.org/10.3389/fonc.2022.806153 Text en Copyright © 2022 Pakela, Knopf, Dong, Rucinski and Zou https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Pakela, Julia M.
Knopf, Antje
Dong, Lei
Rucinski, Antoni
Zou, Wei
Management of Motion and Anatomical Variations in Charged Particle Therapy: Past, Present, and Into the Future
title Management of Motion and Anatomical Variations in Charged Particle Therapy: Past, Present, and Into the Future
title_full Management of Motion and Anatomical Variations in Charged Particle Therapy: Past, Present, and Into the Future
title_fullStr Management of Motion and Anatomical Variations in Charged Particle Therapy: Past, Present, and Into the Future
title_full_unstemmed Management of Motion and Anatomical Variations in Charged Particle Therapy: Past, Present, and Into the Future
title_short Management of Motion and Anatomical Variations in Charged Particle Therapy: Past, Present, and Into the Future
title_sort management of motion and anatomical variations in charged particle therapy: past, present, and into the future
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8959592/
https://www.ncbi.nlm.nih.gov/pubmed/35356213
http://dx.doi.org/10.3389/fonc.2022.806153
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