Cargando…
Management of Motion and Anatomical Variations in Charged Particle Therapy: Past, Present, and Into the Future
The major aim of radiation therapy is to provide curative or palliative treatment to cancerous malignancies while minimizing damage to healthy tissues. Charged particle radiotherapy utilizing carbon ions or protons is uniquely suited for this task due to its ability to achieve highly conformal dose...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8959592/ https://www.ncbi.nlm.nih.gov/pubmed/35356213 http://dx.doi.org/10.3389/fonc.2022.806153 |
_version_ | 1784677191415496704 |
---|---|
author | Pakela, Julia M. Knopf, Antje Dong, Lei Rucinski, Antoni Zou, Wei |
author_facet | Pakela, Julia M. Knopf, Antje Dong, Lei Rucinski, Antoni Zou, Wei |
author_sort | Pakela, Julia M. |
collection | PubMed |
description | The major aim of radiation therapy is to provide curative or palliative treatment to cancerous malignancies while minimizing damage to healthy tissues. Charged particle radiotherapy utilizing carbon ions or protons is uniquely suited for this task due to its ability to achieve highly conformal dose distributions around the tumor volume. For these treatment modalities, uncertainties in the localization of patient anatomy due to inter- and intra-fractional motion present a heightened risk of undesired dose delivery. A diverse range of mitigation strategies have been developed and clinically implemented in various disease sites to monitor and correct for patient motion, but much work remains. This review provides an overview of current clinical practices for inter and intra-fractional motion management in charged particle therapy, including motion control, current imaging and motion tracking modalities, as well as treatment planning and delivery techniques. We also cover progress to date on emerging technologies including particle-based radiography imaging, novel treatment delivery methods such as tumor tracking and FLASH, and artificial intelligence and discuss their potential impact towards improving or increasing the challenge of motion mitigation in charged particle therapy. |
format | Online Article Text |
id | pubmed-8959592 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-89595922022-03-29 Management of Motion and Anatomical Variations in Charged Particle Therapy: Past, Present, and Into the Future Pakela, Julia M. Knopf, Antje Dong, Lei Rucinski, Antoni Zou, Wei Front Oncol Oncology The major aim of radiation therapy is to provide curative or palliative treatment to cancerous malignancies while minimizing damage to healthy tissues. Charged particle radiotherapy utilizing carbon ions or protons is uniquely suited for this task due to its ability to achieve highly conformal dose distributions around the tumor volume. For these treatment modalities, uncertainties in the localization of patient anatomy due to inter- and intra-fractional motion present a heightened risk of undesired dose delivery. A diverse range of mitigation strategies have been developed and clinically implemented in various disease sites to monitor and correct for patient motion, but much work remains. This review provides an overview of current clinical practices for inter and intra-fractional motion management in charged particle therapy, including motion control, current imaging and motion tracking modalities, as well as treatment planning and delivery techniques. We also cover progress to date on emerging technologies including particle-based radiography imaging, novel treatment delivery methods such as tumor tracking and FLASH, and artificial intelligence and discuss their potential impact towards improving or increasing the challenge of motion mitigation in charged particle therapy. Frontiers Media S.A. 2022-03-09 /pmc/articles/PMC8959592/ /pubmed/35356213 http://dx.doi.org/10.3389/fonc.2022.806153 Text en Copyright © 2022 Pakela, Knopf, Dong, Rucinski and Zou https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Pakela, Julia M. Knopf, Antje Dong, Lei Rucinski, Antoni Zou, Wei Management of Motion and Anatomical Variations in Charged Particle Therapy: Past, Present, and Into the Future |
title | Management of Motion and Anatomical Variations in Charged Particle Therapy: Past, Present, and Into the Future |
title_full | Management of Motion and Anatomical Variations in Charged Particle Therapy: Past, Present, and Into the Future |
title_fullStr | Management of Motion and Anatomical Variations in Charged Particle Therapy: Past, Present, and Into the Future |
title_full_unstemmed | Management of Motion and Anatomical Variations in Charged Particle Therapy: Past, Present, and Into the Future |
title_short | Management of Motion and Anatomical Variations in Charged Particle Therapy: Past, Present, and Into the Future |
title_sort | management of motion and anatomical variations in charged particle therapy: past, present, and into the future |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8959592/ https://www.ncbi.nlm.nih.gov/pubmed/35356213 http://dx.doi.org/10.3389/fonc.2022.806153 |
work_keys_str_mv | AT pakelajuliam managementofmotionandanatomicalvariationsinchargedparticletherapypastpresentandintothefuture AT knopfantje managementofmotionandanatomicalvariationsinchargedparticletherapypastpresentandintothefuture AT donglei managementofmotionandanatomicalvariationsinchargedparticletherapypastpresentandintothefuture AT rucinskiantoni managementofmotionandanatomicalvariationsinchargedparticletherapypastpresentandintothefuture AT zouwei managementofmotionandanatomicalvariationsinchargedparticletherapypastpresentandintothefuture |