The Antiarrhythmic Mechanisms of Flecainide in Catecholaminergic Polymorphic Ventricular Tachycardia

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a severe yet rare inherited arrhythmia disorder. The cornerstone of CPVT medical therapy is the use of β-blockers; 30% of patients with CPVT do not respond well to optimal β-blocker treatment. Studies have shown that flecainide effectiv...

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Autores principales: Li, Yukun, Peng, Xiaodong, Lin, Rong, Wang, Xuesi, Liu, Xinmeng, Bai, Rong, Ma, Changsheng, Tang, Ribo, Ruan, Yanfei, Liu, Nian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8959698/
https://www.ncbi.nlm.nih.gov/pubmed/35356081
http://dx.doi.org/10.3389/fphys.2022.850117
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author Li, Yukun
Peng, Xiaodong
Lin, Rong
Wang, Xuesi
Liu, Xinmeng
Bai, Rong
Ma, Changsheng
Tang, Ribo
Ruan, Yanfei
Liu, Nian
author_facet Li, Yukun
Peng, Xiaodong
Lin, Rong
Wang, Xuesi
Liu, Xinmeng
Bai, Rong
Ma, Changsheng
Tang, Ribo
Ruan, Yanfei
Liu, Nian
author_sort Li, Yukun
collection PubMed
description Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a severe yet rare inherited arrhythmia disorder. The cornerstone of CPVT medical therapy is the use of β-blockers; 30% of patients with CPVT do not respond well to optimal β-blocker treatment. Studies have shown that flecainide effectively prevents life-threatening arrhythmias in CPVT. Flecainide is a class IC antiarrhythmic drug blocking cardiac sodium channels. RyR2 inhibition is proposed as the principal mechanism of antiarrhythmic action of flecainide in CPVT, while it is highly debated. In this article, we review the current progress of this issue.
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spelling pubmed-89596982022-03-29 The Antiarrhythmic Mechanisms of Flecainide in Catecholaminergic Polymorphic Ventricular Tachycardia Li, Yukun Peng, Xiaodong Lin, Rong Wang, Xuesi Liu, Xinmeng Bai, Rong Ma, Changsheng Tang, Ribo Ruan, Yanfei Liu, Nian Front Physiol Physiology Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a severe yet rare inherited arrhythmia disorder. The cornerstone of CPVT medical therapy is the use of β-blockers; 30% of patients with CPVT do not respond well to optimal β-blocker treatment. Studies have shown that flecainide effectively prevents life-threatening arrhythmias in CPVT. Flecainide is a class IC antiarrhythmic drug blocking cardiac sodium channels. RyR2 inhibition is proposed as the principal mechanism of antiarrhythmic action of flecainide in CPVT, while it is highly debated. In this article, we review the current progress of this issue. Frontiers Media S.A. 2022-03-09 /pmc/articles/PMC8959698/ /pubmed/35356081 http://dx.doi.org/10.3389/fphys.2022.850117 Text en Copyright © 2022 Li, Peng, Lin, Wang, Liu, Bai, Ma, Tang, Ruan and Liu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Li, Yukun
Peng, Xiaodong
Lin, Rong
Wang, Xuesi
Liu, Xinmeng
Bai, Rong
Ma, Changsheng
Tang, Ribo
Ruan, Yanfei
Liu, Nian
The Antiarrhythmic Mechanisms of Flecainide in Catecholaminergic Polymorphic Ventricular Tachycardia
title The Antiarrhythmic Mechanisms of Flecainide in Catecholaminergic Polymorphic Ventricular Tachycardia
title_full The Antiarrhythmic Mechanisms of Flecainide in Catecholaminergic Polymorphic Ventricular Tachycardia
title_fullStr The Antiarrhythmic Mechanisms of Flecainide in Catecholaminergic Polymorphic Ventricular Tachycardia
title_full_unstemmed The Antiarrhythmic Mechanisms of Flecainide in Catecholaminergic Polymorphic Ventricular Tachycardia
title_short The Antiarrhythmic Mechanisms of Flecainide in Catecholaminergic Polymorphic Ventricular Tachycardia
title_sort antiarrhythmic mechanisms of flecainide in catecholaminergic polymorphic ventricular tachycardia
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8959698/
https://www.ncbi.nlm.nih.gov/pubmed/35356081
http://dx.doi.org/10.3389/fphys.2022.850117
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