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The Emerging Roles of LINC00665 in Human Cancers

Long non-coding RNAs (lncRNAs) are non-coding RNAs that have more than 200 nucleotides and can participate in the regulation of gene expression in various ways. An increasing number of studies have shown that the dysregulated expression of lncRNAs is related to the occurrence and progression of huma...

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Autores principales: Zhu, Jing, Zhang, Yirao, Chen, Xuyu, Bian, Yibo, Li, Juan, Wang, Keming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8959703/
https://www.ncbi.nlm.nih.gov/pubmed/35356290
http://dx.doi.org/10.3389/fcell.2022.839177
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author Zhu, Jing
Zhang, Yirao
Chen, Xuyu
Bian, Yibo
Li, Juan
Wang, Keming
author_facet Zhu, Jing
Zhang, Yirao
Chen, Xuyu
Bian, Yibo
Li, Juan
Wang, Keming
author_sort Zhu, Jing
collection PubMed
description Long non-coding RNAs (lncRNAs) are non-coding RNAs that have more than 200 nucleotides and can participate in the regulation of gene expression in various ways. An increasing number of studies have shown that the dysregulated expression of lncRNAs is related to the occurrence and progression of human cancers. LINC00665 is a novel lncRNA, which is abnormally expressed in various human cancers, such as lung cancer, breast cancer, prostate cancer, and glioma. LINC00665 functions in many biological processes of tumor cells, such as cell proliferation, migration, invasion, angiogenesis, and metabolism, and is related to the clinicopathological characteristics of cancer patients. LINC00665 can play biological functions as a ceRNA, directly binding and interacting with proteins, and as an upstream molecule regulating multiple signaling pathways. In this review, we comprehensively summarize the expression level, function, and molecular mechanisms of LINC00665 in different human cancers and emphasize that LINC00665 is a promising new diagnostic, prognostic biomarker, and therapeutic target.
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spelling pubmed-89597032022-03-29 The Emerging Roles of LINC00665 in Human Cancers Zhu, Jing Zhang, Yirao Chen, Xuyu Bian, Yibo Li, Juan Wang, Keming Front Cell Dev Biol Cell and Developmental Biology Long non-coding RNAs (lncRNAs) are non-coding RNAs that have more than 200 nucleotides and can participate in the regulation of gene expression in various ways. An increasing number of studies have shown that the dysregulated expression of lncRNAs is related to the occurrence and progression of human cancers. LINC00665 is a novel lncRNA, which is abnormally expressed in various human cancers, such as lung cancer, breast cancer, prostate cancer, and glioma. LINC00665 functions in many biological processes of tumor cells, such as cell proliferation, migration, invasion, angiogenesis, and metabolism, and is related to the clinicopathological characteristics of cancer patients. LINC00665 can play biological functions as a ceRNA, directly binding and interacting with proteins, and as an upstream molecule regulating multiple signaling pathways. In this review, we comprehensively summarize the expression level, function, and molecular mechanisms of LINC00665 in different human cancers and emphasize that LINC00665 is a promising new diagnostic, prognostic biomarker, and therapeutic target. Frontiers Media S.A. 2022-03-09 /pmc/articles/PMC8959703/ /pubmed/35356290 http://dx.doi.org/10.3389/fcell.2022.839177 Text en Copyright © 2022 Zhu, Zhang, Chen, Bian, Li and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Zhu, Jing
Zhang, Yirao
Chen, Xuyu
Bian, Yibo
Li, Juan
Wang, Keming
The Emerging Roles of LINC00665 in Human Cancers
title The Emerging Roles of LINC00665 in Human Cancers
title_full The Emerging Roles of LINC00665 in Human Cancers
title_fullStr The Emerging Roles of LINC00665 in Human Cancers
title_full_unstemmed The Emerging Roles of LINC00665 in Human Cancers
title_short The Emerging Roles of LINC00665 in Human Cancers
title_sort emerging roles of linc00665 in human cancers
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8959703/
https://www.ncbi.nlm.nih.gov/pubmed/35356290
http://dx.doi.org/10.3389/fcell.2022.839177
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