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Infant Formula Supplemented With Milk Fat Globule Membrane, Long-Chain Polyunsaturated Fatty Acids, and Synbiotics Is Associated With Neurocognitive Function and Brain Structure of Healthy Children Aged 6 Years: The COGNIS Study
BACKGROUND: Adequate nutrient intake during the first few months of life plays a critical role on brain structure and function development. OBJECTIVES: To analyze the long-term effects of an experimental infant formula (EF) on neurocognitive function and brain structure in healthy children aged 6 ye...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8959863/ https://www.ncbi.nlm.nih.gov/pubmed/35356726 http://dx.doi.org/10.3389/fnut.2022.820224 |
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author | Nieto-Ruiz, Ana García-Santos, José A. Verdejo-Román, Juan Diéguez, Estefanía Sepúlveda-Valbuena, Natalia Herrmann, Florian Cerdó, Tomás De-Castellar, Roser Jiménez, Jesús Bermúdez, Mercedes G. Pérez-García, Miguel Miranda, M. Teresa López-Sabater, M. Carmen Catena, Andrés Campoy, Cristina |
author_facet | Nieto-Ruiz, Ana García-Santos, José A. Verdejo-Román, Juan Diéguez, Estefanía Sepúlveda-Valbuena, Natalia Herrmann, Florian Cerdó, Tomás De-Castellar, Roser Jiménez, Jesús Bermúdez, Mercedes G. Pérez-García, Miguel Miranda, M. Teresa López-Sabater, M. Carmen Catena, Andrés Campoy, Cristina |
author_sort | Nieto-Ruiz, Ana |
collection | PubMed |
description | BACKGROUND: Adequate nutrient intake during the first few months of life plays a critical role on brain structure and function development. OBJECTIVES: To analyze the long-term effects of an experimental infant formula (EF) on neurocognitive function and brain structure in healthy children aged 6 years compared to those fed with a standard infant formula or breastfed. METHODS: The current study involved 108 healthy children aged 6 years and participating in the COGNIS Study. At 0–2 months, infants were randomized to receive up to 18 months of life a standard infant formula (SF) or EF enriched with milk fat globule membrane (MFGM), long-chain polyunsaturated fatty acids (LC-PUFAs) and synbiotics. Furthermore, a reference group of breastfed (BF) infants were also recruited. Children were assessed using neurocognitive tests and structural Magnetic Resonance Imaging (MRI) at 6 years old. RESULTS: Experimental infant formula (EF) children showed greater volumes in the left orbital cortex, higher vocabulary scores and IQ, and better performance in an attention task than BF children. EF children also presented greater volumes in parietal regions than SF kids. Additionally, greater cortical thickness in the insular, parietal, and temporal areas were found in children from the EF group than those fed with SF or BF groups. Further correlation analyses suggest that higher volumes and cortical thickness of different parietal and frontal regions are associated with better cognitive development in terms of language (verbal comprehension) and executive function (working memory). Finally, arachidonic acid (ARA), adrenic acid (AdA), docosahexaenoic acid (DHA) levels in cheek cell glycerophospholipids, ARA/DHA ratio, and protein, fatty acid, and mineral intake during the first 18 months of life seem to be associated with changes in the brain structures at 6 years old. CONCLUSIONS: Supplemented infant formula with MFGM components, LC-PUFAs, and synbiotics seems to be associated to long-term effects on neurocognitive development and brain structure in children at 6 years old. CLINICAL TRIAL REGISTRATION: https://www.clinicaltrials.gov/, identifier: NCT02094547. |
format | Online Article Text |
id | pubmed-8959863 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-89598632022-03-29 Infant Formula Supplemented With Milk Fat Globule Membrane, Long-Chain Polyunsaturated Fatty Acids, and Synbiotics Is Associated With Neurocognitive Function and Brain Structure of Healthy Children Aged 6 Years: The COGNIS Study Nieto-Ruiz, Ana García-Santos, José A. Verdejo-Román, Juan Diéguez, Estefanía Sepúlveda-Valbuena, Natalia Herrmann, Florian Cerdó, Tomás De-Castellar, Roser Jiménez, Jesús Bermúdez, Mercedes G. Pérez-García, Miguel Miranda, M. Teresa López-Sabater, M. Carmen Catena, Andrés Campoy, Cristina Front Nutr Nutrition BACKGROUND: Adequate nutrient intake during the first few months of life plays a critical role on brain structure and function development. OBJECTIVES: To analyze the long-term effects of an experimental infant formula (EF) on neurocognitive function and brain structure in healthy children aged 6 years compared to those fed with a standard infant formula or breastfed. METHODS: The current study involved 108 healthy children aged 6 years and participating in the COGNIS Study. At 0–2 months, infants were randomized to receive up to 18 months of life a standard infant formula (SF) or EF enriched with milk fat globule membrane (MFGM), long-chain polyunsaturated fatty acids (LC-PUFAs) and synbiotics. Furthermore, a reference group of breastfed (BF) infants were also recruited. Children were assessed using neurocognitive tests and structural Magnetic Resonance Imaging (MRI) at 6 years old. RESULTS: Experimental infant formula (EF) children showed greater volumes in the left orbital cortex, higher vocabulary scores and IQ, and better performance in an attention task than BF children. EF children also presented greater volumes in parietal regions than SF kids. Additionally, greater cortical thickness in the insular, parietal, and temporal areas were found in children from the EF group than those fed with SF or BF groups. Further correlation analyses suggest that higher volumes and cortical thickness of different parietal and frontal regions are associated with better cognitive development in terms of language (verbal comprehension) and executive function (working memory). Finally, arachidonic acid (ARA), adrenic acid (AdA), docosahexaenoic acid (DHA) levels in cheek cell glycerophospholipids, ARA/DHA ratio, and protein, fatty acid, and mineral intake during the first 18 months of life seem to be associated with changes in the brain structures at 6 years old. CONCLUSIONS: Supplemented infant formula with MFGM components, LC-PUFAs, and synbiotics seems to be associated to long-term effects on neurocognitive development and brain structure in children at 6 years old. CLINICAL TRIAL REGISTRATION: https://www.clinicaltrials.gov/, identifier: NCT02094547. Frontiers Media S.A. 2022-03-09 /pmc/articles/PMC8959863/ /pubmed/35356726 http://dx.doi.org/10.3389/fnut.2022.820224 Text en Copyright © 2022 Nieto-Ruiz, García-Santos, Verdejo-Román, Diéguez, Sepúlveda-Valbuena, Herrmann, Cerdó, De-Castellar, Jiménez, Bermúdez, Pérez-García, Miranda, López-Sabater, Catena and Campoy. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Nutrition Nieto-Ruiz, Ana García-Santos, José A. Verdejo-Román, Juan Diéguez, Estefanía Sepúlveda-Valbuena, Natalia Herrmann, Florian Cerdó, Tomás De-Castellar, Roser Jiménez, Jesús Bermúdez, Mercedes G. Pérez-García, Miguel Miranda, M. Teresa López-Sabater, M. Carmen Catena, Andrés Campoy, Cristina Infant Formula Supplemented With Milk Fat Globule Membrane, Long-Chain Polyunsaturated Fatty Acids, and Synbiotics Is Associated With Neurocognitive Function and Brain Structure of Healthy Children Aged 6 Years: The COGNIS Study |
title | Infant Formula Supplemented With Milk Fat Globule Membrane, Long-Chain Polyunsaturated Fatty Acids, and Synbiotics Is Associated With Neurocognitive Function and Brain Structure of Healthy Children Aged 6 Years: The COGNIS Study |
title_full | Infant Formula Supplemented With Milk Fat Globule Membrane, Long-Chain Polyunsaturated Fatty Acids, and Synbiotics Is Associated With Neurocognitive Function and Brain Structure of Healthy Children Aged 6 Years: The COGNIS Study |
title_fullStr | Infant Formula Supplemented With Milk Fat Globule Membrane, Long-Chain Polyunsaturated Fatty Acids, and Synbiotics Is Associated With Neurocognitive Function and Brain Structure of Healthy Children Aged 6 Years: The COGNIS Study |
title_full_unstemmed | Infant Formula Supplemented With Milk Fat Globule Membrane, Long-Chain Polyunsaturated Fatty Acids, and Synbiotics Is Associated With Neurocognitive Function and Brain Structure of Healthy Children Aged 6 Years: The COGNIS Study |
title_short | Infant Formula Supplemented With Milk Fat Globule Membrane, Long-Chain Polyunsaturated Fatty Acids, and Synbiotics Is Associated With Neurocognitive Function and Brain Structure of Healthy Children Aged 6 Years: The COGNIS Study |
title_sort | infant formula supplemented with milk fat globule membrane, long-chain polyunsaturated fatty acids, and synbiotics is associated with neurocognitive function and brain structure of healthy children aged 6 years: the cognis study |
topic | Nutrition |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8959863/ https://www.ncbi.nlm.nih.gov/pubmed/35356726 http://dx.doi.org/10.3389/fnut.2022.820224 |
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