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Molecular Characteristics and Prognostic Role of MFAP2 in Stomach Adenocarcinoma

Molecular characteristics and prognostic role of MFAP2 were by no means stated. The MFAP2 expression and prognostic prices in this study, with Cox analysis, was employed to develop a predictive fee for MFAP2. To know about coexpression and practical networks associated with MFAP2, LinkedOmics and GE...

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Detalles Bibliográficos
Autores principales: Tang, Fenfen, Hu, Chaoyi, Long, Zhi, Liu, Yanping, Li, Guoqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8959993/
https://www.ncbi.nlm.nih.gov/pubmed/35356627
http://dx.doi.org/10.1155/2022/1417238
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author Tang, Fenfen
Hu, Chaoyi
Long, Zhi
Liu, Yanping
Li, Guoqing
author_facet Tang, Fenfen
Hu, Chaoyi
Long, Zhi
Liu, Yanping
Li, Guoqing
author_sort Tang, Fenfen
collection PubMed
description Molecular characteristics and prognostic role of MFAP2 were by no means stated. The MFAP2 expression and prognostic prices in this study, with Cox analysis, was employed to develop a predictive fee for MFAP2. To know about coexpression and practical networks associated with MFAP2, LinkedOmics and GEPIA2 have been used. MFAP2 expression has been increased and verified in many unbiased coalitions in TCGA-STAD tumor tissues. In addition, in each TCGA and various cohorts, increased MFAP2 was linked with lower survival. Evaluation by Cox revealed the unbiased danger to average survival, disease-specific survival, and progression-free survival of STAD used to be due to the elevated expression of MFAP2. Active community assessed the MFAP2, through which more than a few cancer-associated kinases and E2F household pathways are regulated, which shows that MFAP2 affects RNA transportation, oocyte meiosis, spliceosome, and ribosome biogenesis. MFAP2 can predict and is linked to the prediction of STAD independently. The closure of the MFAP2 link to the macrophage marker genes is, in particular, the achievable core of immune response.
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spelling pubmed-89599932022-03-29 Molecular Characteristics and Prognostic Role of MFAP2 in Stomach Adenocarcinoma Tang, Fenfen Hu, Chaoyi Long, Zhi Liu, Yanping Li, Guoqing J Healthc Eng Research Article Molecular characteristics and prognostic role of MFAP2 were by no means stated. The MFAP2 expression and prognostic prices in this study, with Cox analysis, was employed to develop a predictive fee for MFAP2. To know about coexpression and practical networks associated with MFAP2, LinkedOmics and GEPIA2 have been used. MFAP2 expression has been increased and verified in many unbiased coalitions in TCGA-STAD tumor tissues. In addition, in each TCGA and various cohorts, increased MFAP2 was linked with lower survival. Evaluation by Cox revealed the unbiased danger to average survival, disease-specific survival, and progression-free survival of STAD used to be due to the elevated expression of MFAP2. Active community assessed the MFAP2, through which more than a few cancer-associated kinases and E2F household pathways are regulated, which shows that MFAP2 affects RNA transportation, oocyte meiosis, spliceosome, and ribosome biogenesis. MFAP2 can predict and is linked to the prediction of STAD independently. The closure of the MFAP2 link to the macrophage marker genes is, in particular, the achievable core of immune response. Hindawi 2022-03-21 /pmc/articles/PMC8959993/ /pubmed/35356627 http://dx.doi.org/10.1155/2022/1417238 Text en Copyright © 2022 Fenfen Tang et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Tang, Fenfen
Hu, Chaoyi
Long, Zhi
Liu, Yanping
Li, Guoqing
Molecular Characteristics and Prognostic Role of MFAP2 in Stomach Adenocarcinoma
title Molecular Characteristics and Prognostic Role of MFAP2 in Stomach Adenocarcinoma
title_full Molecular Characteristics and Prognostic Role of MFAP2 in Stomach Adenocarcinoma
title_fullStr Molecular Characteristics and Prognostic Role of MFAP2 in Stomach Adenocarcinoma
title_full_unstemmed Molecular Characteristics and Prognostic Role of MFAP2 in Stomach Adenocarcinoma
title_short Molecular Characteristics and Prognostic Role of MFAP2 in Stomach Adenocarcinoma
title_sort molecular characteristics and prognostic role of mfap2 in stomach adenocarcinoma
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8959993/
https://www.ncbi.nlm.nih.gov/pubmed/35356627
http://dx.doi.org/10.1155/2022/1417238
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