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Analysis of Related Risk Factors of Microvascular Invasion in Hepatocellular Carcinoma
OBJECTIVE: To forecast the onset of microvascular invasion (MVI) in patients with hepatoma by evaluating the preoperative aspartate aminotransferase-to-platelet ratio index (APRI), alpha-fetoprotein (AFP), neutrophil-to-lymphocyte ratio (NLR), and other clinicopathological data. METHODS: In this stu...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8960018/ https://www.ncbi.nlm.nih.gov/pubmed/35356664 http://dx.doi.org/10.1155/2022/8195512 |
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author | Shi, Longqing Qu, Zhen Yang, Yue Zhang, Yue Sun, Donglin |
author_facet | Shi, Longqing Qu, Zhen Yang, Yue Zhang, Yue Sun, Donglin |
author_sort | Shi, Longqing |
collection | PubMed |
description | OBJECTIVE: To forecast the onset of microvascular invasion (MVI) in patients with hepatoma by evaluating the preoperative aspartate aminotransferase-to-platelet ratio index (APRI), alpha-fetoprotein (AFP), neutrophil-to-lymphocyte ratio (NLR), and other clinicopathological data. METHODS: In this study, we retrospectively analysed the clinical data of 62 patients who received radical surgery for hepa toma from 2019 to 2021. Patients were separated into the MVI-negative group and the MVI-positive group according to the postoperative pathological diagnosis. The relationships between MVI and NLR, APRI, AFP, tumor size, and other clinical data were assessed using the univariate analysis, receiver operating characteristic (ROC) curve, least absolute shrinkage and selection operator (LASSO) analysis, and logistic analysis. RESULTS: The ROC curve determined that the cutoff values of NLR, platelet-to-lymphocyte ratio (PLR), and APRI were 1.520, 98, and 0.275, respectively. The univariate analysis showed that the MVI-positive result was associated with five factors: tumor size (χ(2) = 10.620, p = 0.001), AFP (χ(2) = 10.524, p = 0.001), Edmondson grade (χ(2) = 20.736, p < 0.001), NLR (χ(2) = 8.744, p = 0.003), and APRI (χ(2) = 4.849, p = 0.028). The LASSO analysis indicated that the risk factors were the number of tumors, PLR, APRI, NLR, AFP, Edmondson grade, and tumor size. The multivariate logistic regression analysis showed that NLR ≥ 1.520 (OR 11.119, p = 0.006), APRI ≥ 0.275 (OR 12.515, p = 0.009), AFP ≥ 200 μg/mL (OR 7.823, p = 0.016), and tumor size > 3 cm (OR 7.689, p = 0.022) were independent risk factors for MVI in patients with hepatoma. CONCLUSION: Preoperative NLR, APRI, AFP, and tumor size are reliable indicators for predicting the appearance of MVI in patients with hepatoma and are of great value in making detailed and reliable treatment protocols for these patients before surgery. |
format | Online Article Text |
id | pubmed-8960018 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-89600182022-03-29 Analysis of Related Risk Factors of Microvascular Invasion in Hepatocellular Carcinoma Shi, Longqing Qu, Zhen Yang, Yue Zhang, Yue Sun, Donglin Comput Math Methods Med Research Article OBJECTIVE: To forecast the onset of microvascular invasion (MVI) in patients with hepatoma by evaluating the preoperative aspartate aminotransferase-to-platelet ratio index (APRI), alpha-fetoprotein (AFP), neutrophil-to-lymphocyte ratio (NLR), and other clinicopathological data. METHODS: In this study, we retrospectively analysed the clinical data of 62 patients who received radical surgery for hepa toma from 2019 to 2021. Patients were separated into the MVI-negative group and the MVI-positive group according to the postoperative pathological diagnosis. The relationships between MVI and NLR, APRI, AFP, tumor size, and other clinical data were assessed using the univariate analysis, receiver operating characteristic (ROC) curve, least absolute shrinkage and selection operator (LASSO) analysis, and logistic analysis. RESULTS: The ROC curve determined that the cutoff values of NLR, platelet-to-lymphocyte ratio (PLR), and APRI were 1.520, 98, and 0.275, respectively. The univariate analysis showed that the MVI-positive result was associated with five factors: tumor size (χ(2) = 10.620, p = 0.001), AFP (χ(2) = 10.524, p = 0.001), Edmondson grade (χ(2) = 20.736, p < 0.001), NLR (χ(2) = 8.744, p = 0.003), and APRI (χ(2) = 4.849, p = 0.028). The LASSO analysis indicated that the risk factors were the number of tumors, PLR, APRI, NLR, AFP, Edmondson grade, and tumor size. The multivariate logistic regression analysis showed that NLR ≥ 1.520 (OR 11.119, p = 0.006), APRI ≥ 0.275 (OR 12.515, p = 0.009), AFP ≥ 200 μg/mL (OR 7.823, p = 0.016), and tumor size > 3 cm (OR 7.689, p = 0.022) were independent risk factors for MVI in patients with hepatoma. CONCLUSION: Preoperative NLR, APRI, AFP, and tumor size are reliable indicators for predicting the appearance of MVI in patients with hepatoma and are of great value in making detailed and reliable treatment protocols for these patients before surgery. Hindawi 2022-03-21 /pmc/articles/PMC8960018/ /pubmed/35356664 http://dx.doi.org/10.1155/2022/8195512 Text en Copyright © 2022 Longqing Shi et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Shi, Longqing Qu, Zhen Yang, Yue Zhang, Yue Sun, Donglin Analysis of Related Risk Factors of Microvascular Invasion in Hepatocellular Carcinoma |
title | Analysis of Related Risk Factors of Microvascular Invasion in Hepatocellular Carcinoma |
title_full | Analysis of Related Risk Factors of Microvascular Invasion in Hepatocellular Carcinoma |
title_fullStr | Analysis of Related Risk Factors of Microvascular Invasion in Hepatocellular Carcinoma |
title_full_unstemmed | Analysis of Related Risk Factors of Microvascular Invasion in Hepatocellular Carcinoma |
title_short | Analysis of Related Risk Factors of Microvascular Invasion in Hepatocellular Carcinoma |
title_sort | analysis of related risk factors of microvascular invasion in hepatocellular carcinoma |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8960018/ https://www.ncbi.nlm.nih.gov/pubmed/35356664 http://dx.doi.org/10.1155/2022/8195512 |
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