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Engineering strategies for customizing extracellular vesicle uptake in a therapeutic context
Extracellular vesicles (EVs) are advanced therapeutic strategies that can be used to efficiently treat diseases. Promising features of EVs include their innate therapeutic properties and ability to be engineered as targeted drug delivery systems. However, regulation of EV uptake is one challenge of...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8960087/ https://www.ncbi.nlm.nih.gov/pubmed/35346367 http://dx.doi.org/10.1186/s13287-022-02806-2 |
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author | Esmaeili, Abazar Alini, Mauro Baghaban Eslaminejad, Mohamadreza Hosseini, Samaneh |
author_facet | Esmaeili, Abazar Alini, Mauro Baghaban Eslaminejad, Mohamadreza Hosseini, Samaneh |
author_sort | Esmaeili, Abazar |
collection | PubMed |
description | Extracellular vesicles (EVs) are advanced therapeutic strategies that can be used to efficiently treat diseases. Promising features of EVs include their innate therapeutic properties and ability to be engineered as targeted drug delivery systems. However, regulation of EV uptake is one challenge of EV therapy that must be overcome to achieve an efficient therapeutic outcome. Numerous efforts to improve the factors that affect EV uptake include the selection of a cell source, cell cultivation procedure, extraction and purification methods, storage, and administration routes. Limitations of rapid clearance, targeted delivery, and off-targeting of EVs are current challenges that must be circumvented. EV engineering can potentially overcome these limitations and provide an ideal therapeutic use for EVs. In this paper, we intend to discuss traditional strategies and their limitations, and then review recent advances in EV engineering that can be used to customize and control EV uptake for future clinical applications. |
format | Online Article Text |
id | pubmed-8960087 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-89600872022-03-29 Engineering strategies for customizing extracellular vesicle uptake in a therapeutic context Esmaeili, Abazar Alini, Mauro Baghaban Eslaminejad, Mohamadreza Hosseini, Samaneh Stem Cell Res Ther Review Extracellular vesicles (EVs) are advanced therapeutic strategies that can be used to efficiently treat diseases. Promising features of EVs include their innate therapeutic properties and ability to be engineered as targeted drug delivery systems. However, regulation of EV uptake is one challenge of EV therapy that must be overcome to achieve an efficient therapeutic outcome. Numerous efforts to improve the factors that affect EV uptake include the selection of a cell source, cell cultivation procedure, extraction and purification methods, storage, and administration routes. Limitations of rapid clearance, targeted delivery, and off-targeting of EVs are current challenges that must be circumvented. EV engineering can potentially overcome these limitations and provide an ideal therapeutic use for EVs. In this paper, we intend to discuss traditional strategies and their limitations, and then review recent advances in EV engineering that can be used to customize and control EV uptake for future clinical applications. BioMed Central 2022-03-28 /pmc/articles/PMC8960087/ /pubmed/35346367 http://dx.doi.org/10.1186/s13287-022-02806-2 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Review Esmaeili, Abazar Alini, Mauro Baghaban Eslaminejad, Mohamadreza Hosseini, Samaneh Engineering strategies for customizing extracellular vesicle uptake in a therapeutic context |
title | Engineering strategies for customizing extracellular vesicle uptake in a therapeutic context |
title_full | Engineering strategies for customizing extracellular vesicle uptake in a therapeutic context |
title_fullStr | Engineering strategies for customizing extracellular vesicle uptake in a therapeutic context |
title_full_unstemmed | Engineering strategies for customizing extracellular vesicle uptake in a therapeutic context |
title_short | Engineering strategies for customizing extracellular vesicle uptake in a therapeutic context |
title_sort | engineering strategies for customizing extracellular vesicle uptake in a therapeutic context |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8960087/ https://www.ncbi.nlm.nih.gov/pubmed/35346367 http://dx.doi.org/10.1186/s13287-022-02806-2 |
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