Cargando…

Seroconversion dynamic and SARS-CoV-2 seropositivity in unvaccinated population during the first and second outbreaks in Mexico

Serosurveillance helps establish reopening guidelines and determine the immunity levels in different populations to reach herd immunity. Then, there is an urgent need to estimate seroprevalence population wide. In Mexico, information about COVID-19 cases and related deaths is scarce. Also, there is...

Descripción completa

Detalles Bibliográficos
Autores principales: Fernández-Rojas, Miguel A., Luna-Ruiz Esparza, Marco A., Campos-Romero, Abraham, Calva-Espinosa, Diana Y., Moreno-Camacho, José L., Mendlovic, Fela, Plett-Torres, Tanya, Alcántar-Fernández, Jonathan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8960100/
https://www.ncbi.nlm.nih.gov/pubmed/35347208
http://dx.doi.org/10.1038/s41598-022-09395-3
_version_ 1784677314894757888
author Fernández-Rojas, Miguel A.
Luna-Ruiz Esparza, Marco A.
Campos-Romero, Abraham
Calva-Espinosa, Diana Y.
Moreno-Camacho, José L.
Mendlovic, Fela
Plett-Torres, Tanya
Alcántar-Fernández, Jonathan
author_facet Fernández-Rojas, Miguel A.
Luna-Ruiz Esparza, Marco A.
Campos-Romero, Abraham
Calva-Espinosa, Diana Y.
Moreno-Camacho, José L.
Mendlovic, Fela
Plett-Torres, Tanya
Alcántar-Fernández, Jonathan
author_sort Fernández-Rojas, Miguel A.
collection PubMed
description Serosurveillance helps establish reopening guidelines and determine the immunity levels in different populations to reach herd immunity. Then, there is an urgent need to estimate seroprevalence population wide. In Mexico, information about COVID-19 cases and related deaths is scarce. Also, there is no official serosurveillance, limiting our knowledge of the impact of the SARS-CoV-2 pandemic. Here, we report the prevalence of anti-SARS-CoV-2 antibodies in 522,690 unvaccinated people from July 5th to December 31st, 2020. The overall seroprevalence was 32.8% and highest in adults aged 30–39 years (38.5%) than people under 20 years (33.0%) or older (28.9%). Moreover, in a cohort of 1655 individuals confirmed COVID-19 by PCR, we found that symptomatic people (HR = 2.56) increased seroconversion than presymptomatic. Also, we identified that the most discriminative symptoms for COVID-19 that could predict seroconversion were anosmia and ageusia (HR = 1.70), fever, myalgia/arthralgia, and cough (HR = 1.75). Finally, we found that obese people had lower seroconversion (HR = 0.53) than healthy people, but the opposite happens in diabetic people (HR = 1.39). These findings reveal that around one-third of Mexican outpatients had anti-SARS-CoV-2 antibodies before vaccination. Also, some symptoms improve empirically COVID-19 diagnosis and seroconversion. This information could help fine-tune vaccination schemes and the reopening and back-to-work algorithms.
format Online
Article
Text
id pubmed-8960100
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-89601002022-03-29 Seroconversion dynamic and SARS-CoV-2 seropositivity in unvaccinated population during the first and second outbreaks in Mexico Fernández-Rojas, Miguel A. Luna-Ruiz Esparza, Marco A. Campos-Romero, Abraham Calva-Espinosa, Diana Y. Moreno-Camacho, José L. Mendlovic, Fela Plett-Torres, Tanya Alcántar-Fernández, Jonathan Sci Rep Article Serosurveillance helps establish reopening guidelines and determine the immunity levels in different populations to reach herd immunity. Then, there is an urgent need to estimate seroprevalence population wide. In Mexico, information about COVID-19 cases and related deaths is scarce. Also, there is no official serosurveillance, limiting our knowledge of the impact of the SARS-CoV-2 pandemic. Here, we report the prevalence of anti-SARS-CoV-2 antibodies in 522,690 unvaccinated people from July 5th to December 31st, 2020. The overall seroprevalence was 32.8% and highest in adults aged 30–39 years (38.5%) than people under 20 years (33.0%) or older (28.9%). Moreover, in a cohort of 1655 individuals confirmed COVID-19 by PCR, we found that symptomatic people (HR = 2.56) increased seroconversion than presymptomatic. Also, we identified that the most discriminative symptoms for COVID-19 that could predict seroconversion were anosmia and ageusia (HR = 1.70), fever, myalgia/arthralgia, and cough (HR = 1.75). Finally, we found that obese people had lower seroconversion (HR = 0.53) than healthy people, but the opposite happens in diabetic people (HR = 1.39). These findings reveal that around one-third of Mexican outpatients had anti-SARS-CoV-2 antibodies before vaccination. Also, some symptoms improve empirically COVID-19 diagnosis and seroconversion. This information could help fine-tune vaccination schemes and the reopening and back-to-work algorithms. Nature Publishing Group UK 2022-03-28 /pmc/articles/PMC8960100/ /pubmed/35347208 http://dx.doi.org/10.1038/s41598-022-09395-3 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Fernández-Rojas, Miguel A.
Luna-Ruiz Esparza, Marco A.
Campos-Romero, Abraham
Calva-Espinosa, Diana Y.
Moreno-Camacho, José L.
Mendlovic, Fela
Plett-Torres, Tanya
Alcántar-Fernández, Jonathan
Seroconversion dynamic and SARS-CoV-2 seropositivity in unvaccinated population during the first and second outbreaks in Mexico
title Seroconversion dynamic and SARS-CoV-2 seropositivity in unvaccinated population during the first and second outbreaks in Mexico
title_full Seroconversion dynamic and SARS-CoV-2 seropositivity in unvaccinated population during the first and second outbreaks in Mexico
title_fullStr Seroconversion dynamic and SARS-CoV-2 seropositivity in unvaccinated population during the first and second outbreaks in Mexico
title_full_unstemmed Seroconversion dynamic and SARS-CoV-2 seropositivity in unvaccinated population during the first and second outbreaks in Mexico
title_short Seroconversion dynamic and SARS-CoV-2 seropositivity in unvaccinated population during the first and second outbreaks in Mexico
title_sort seroconversion dynamic and sars-cov-2 seropositivity in unvaccinated population during the first and second outbreaks in mexico
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8960100/
https://www.ncbi.nlm.nih.gov/pubmed/35347208
http://dx.doi.org/10.1038/s41598-022-09395-3
work_keys_str_mv AT fernandezrojasmiguela seroconversiondynamicandsarscov2seropositivityinunvaccinatedpopulationduringthefirstandsecondoutbreaksinmexico
AT lunaruizesparzamarcoa seroconversiondynamicandsarscov2seropositivityinunvaccinatedpopulationduringthefirstandsecondoutbreaksinmexico
AT camposromeroabraham seroconversiondynamicandsarscov2seropositivityinunvaccinatedpopulationduringthefirstandsecondoutbreaksinmexico
AT calvaespinosadianay seroconversiondynamicandsarscov2seropositivityinunvaccinatedpopulationduringthefirstandsecondoutbreaksinmexico
AT morenocamachojosel seroconversiondynamicandsarscov2seropositivityinunvaccinatedpopulationduringthefirstandsecondoutbreaksinmexico
AT mendlovicfela seroconversiondynamicandsarscov2seropositivityinunvaccinatedpopulationduringthefirstandsecondoutbreaksinmexico
AT pletttorrestanya seroconversiondynamicandsarscov2seropositivityinunvaccinatedpopulationduringthefirstandsecondoutbreaksinmexico
AT alcantarfernandezjonathan seroconversiondynamicandsarscov2seropositivityinunvaccinatedpopulationduringthefirstandsecondoutbreaksinmexico