Comorbidity of Type 2 Diabetes Mellitus and Depression: Clinical Evidence and Rationale for the Exacerbation of Cardiovascular Disease

Depression is a common comorbidity of type 2 diabetes mellitus (T2DM). T2DM with comorbid depression increases the risk of cardiovascular events and death. Depression and T2DM and its macrovascular complications exhibited a two-way relationship. Regarding treatment, antidepressants can affect the de...

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Autores principales: Zhu, Mengmeng, Li, Yiwen, Luo, Binyu, Cui, Jing, Liu, Yanfei, Liu, Yue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cardiovascular Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8960118/
https://www.ncbi.nlm.nih.gov/pubmed/35360021
http://dx.doi.org/10.3389/fcvm.2022.861110
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author Zhu, Mengmeng
Li, Yiwen
Luo, Binyu
Cui, Jing
Liu, Yanfei
Liu, Yue
author_facet Zhu, Mengmeng
Li, Yiwen
Luo, Binyu
Cui, Jing
Liu, Yanfei
Liu, Yue
author_sort Zhu, Mengmeng
collection PubMed
description Depression is a common comorbidity of type 2 diabetes mellitus (T2DM). T2DM with comorbid depression increases the risk of cardiovascular events and death. Depression and T2DM and its macrovascular complications exhibited a two-way relationship. Regarding treatment, antidepressants can affect the development of T2DM and cardiovascular events, and hypoglycemic drugs can also affect the development of depression and cardiovascular events. The combination of these two types of medications may increase the risk of the first myocardial infarction. Herein, we review the latest research progress in the exacerbation of cardiovascular disease due to T2DM with comorbid depression and provide a rationale and an outlook for the prevention and treatment of cardiovascular disease in T2DM with comorbid depression.
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spelling pubmed-89601182022-03-30 Comorbidity of Type 2 Diabetes Mellitus and Depression: Clinical Evidence and Rationale for the Exacerbation of Cardiovascular Disease Zhu, Mengmeng Li, Yiwen Luo, Binyu Cui, Jing Liu, Yanfei Liu, Yue Front Cardiovasc Med Cardiovascular Medicine Depression is a common comorbidity of type 2 diabetes mellitus (T2DM). T2DM with comorbid depression increases the risk of cardiovascular events and death. Depression and T2DM and its macrovascular complications exhibited a two-way relationship. Regarding treatment, antidepressants can affect the development of T2DM and cardiovascular events, and hypoglycemic drugs can also affect the development of depression and cardiovascular events. The combination of these two types of medications may increase the risk of the first myocardial infarction. Herein, we review the latest research progress in the exacerbation of cardiovascular disease due to T2DM with comorbid depression and provide a rationale and an outlook for the prevention and treatment of cardiovascular disease in T2DM with comorbid depression. Frontiers Media S.A. 2022-03-10 /pmc/articles/PMC8960118/ /pubmed/35360021 http://dx.doi.org/10.3389/fcvm.2022.861110 Text en Copyright © 2022 Zhu, Li, Luo, Cui, Liu and Liu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Zhu, Mengmeng
Li, Yiwen
Luo, Binyu
Cui, Jing
Liu, Yanfei
Liu, Yue
Comorbidity of Type 2 Diabetes Mellitus and Depression: Clinical Evidence and Rationale for the Exacerbation of Cardiovascular Disease
title Comorbidity of Type 2 Diabetes Mellitus and Depression: Clinical Evidence and Rationale for the Exacerbation of Cardiovascular Disease
title_full Comorbidity of Type 2 Diabetes Mellitus and Depression: Clinical Evidence and Rationale for the Exacerbation of Cardiovascular Disease
title_fullStr Comorbidity of Type 2 Diabetes Mellitus and Depression: Clinical Evidence and Rationale for the Exacerbation of Cardiovascular Disease
title_full_unstemmed Comorbidity of Type 2 Diabetes Mellitus and Depression: Clinical Evidence and Rationale for the Exacerbation of Cardiovascular Disease
title_short Comorbidity of Type 2 Diabetes Mellitus and Depression: Clinical Evidence and Rationale for the Exacerbation of Cardiovascular Disease
title_sort comorbidity of type 2 diabetes mellitus and depression: clinical evidence and rationale for the exacerbation of cardiovascular disease
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8960118/
https://www.ncbi.nlm.nih.gov/pubmed/35360021
http://dx.doi.org/10.3389/fcvm.2022.861110
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