Cargando…

Potential of Colostrum-Derived Exosomes for Promoting Hair Regeneration Through the Transition From Telogen to Anagen Phase

Human hair dermal papillary (DP) cells comprising mesenchymal stem cells in hair follicles contribute critically to hair growth and cycle regulation. The transition of hair follicles from telogen to anagen phase is the key to regulating hair growth, which relies heavily on the activation of DP cells...

Descripción completa

Detalles Bibliográficos
Autores principales: Kim, Hyosuk, Jang, Yeongji, Kim, Eun Hye, Jang, Hochung, Cho, Haeun, Han, Geonhee, Song, Hyun Kyu, Kim, Sun Hwa, Yang, Yoosoo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8960251/
https://www.ncbi.nlm.nih.gov/pubmed/35359449
http://dx.doi.org/10.3389/fcell.2022.815205
_version_ 1784677350053511168
author Kim, Hyosuk
Jang, Yeongji
Kim, Eun Hye
Jang, Hochung
Cho, Haeun
Han, Geonhee
Song, Hyun Kyu
Kim, Sun Hwa
Yang, Yoosoo
author_facet Kim, Hyosuk
Jang, Yeongji
Kim, Eun Hye
Jang, Hochung
Cho, Haeun
Han, Geonhee
Song, Hyun Kyu
Kim, Sun Hwa
Yang, Yoosoo
author_sort Kim, Hyosuk
collection PubMed
description Human hair dermal papillary (DP) cells comprising mesenchymal stem cells in hair follicles contribute critically to hair growth and cycle regulation. The transition of hair follicles from telogen to anagen phase is the key to regulating hair growth, which relies heavily on the activation of DP cells. In this paper, we suggested exosomes derived from bovine colostrum (milk exosomes, Milk-exo) as a new effective non-surgical therapy for hair loss. Results showed that Milk-exo promoted the proliferation of hair DP cells and rescued dihydrotestosterone (DHT, androgen hormones)-induced arrest of follicle development. Milk-exo also induced dorsal hair re-growth in mice at the level comparable to minoxidil treatment, without associated adverse effects such as skin rashes. Our data demonstrated that Milk-exo accelerated the hair cycle transition from telogen to anagen phase by activating the Wnt/β-catenin pathway. Interestingly, Milk-exo has been found to stably retain its original properties and efficacy for hair regeneration after freeze-drying and resuspension, which is considered critical to use it as a raw material applied in different types of alopecia medicines and treatments. Overall, this study highlights a great potential of an exosome from colostrum as a therapeutic modality for hair loss.
format Online
Article
Text
id pubmed-8960251
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-89602512022-03-30 Potential of Colostrum-Derived Exosomes for Promoting Hair Regeneration Through the Transition From Telogen to Anagen Phase Kim, Hyosuk Jang, Yeongji Kim, Eun Hye Jang, Hochung Cho, Haeun Han, Geonhee Song, Hyun Kyu Kim, Sun Hwa Yang, Yoosoo Front Cell Dev Biol Cell and Developmental Biology Human hair dermal papillary (DP) cells comprising mesenchymal stem cells in hair follicles contribute critically to hair growth and cycle regulation. The transition of hair follicles from telogen to anagen phase is the key to regulating hair growth, which relies heavily on the activation of DP cells. In this paper, we suggested exosomes derived from bovine colostrum (milk exosomes, Milk-exo) as a new effective non-surgical therapy for hair loss. Results showed that Milk-exo promoted the proliferation of hair DP cells and rescued dihydrotestosterone (DHT, androgen hormones)-induced arrest of follicle development. Milk-exo also induced dorsal hair re-growth in mice at the level comparable to minoxidil treatment, without associated adverse effects such as skin rashes. Our data demonstrated that Milk-exo accelerated the hair cycle transition from telogen to anagen phase by activating the Wnt/β-catenin pathway. Interestingly, Milk-exo has been found to stably retain its original properties and efficacy for hair regeneration after freeze-drying and resuspension, which is considered critical to use it as a raw material applied in different types of alopecia medicines and treatments. Overall, this study highlights a great potential of an exosome from colostrum as a therapeutic modality for hair loss. Frontiers Media S.A. 2022-03-10 /pmc/articles/PMC8960251/ /pubmed/35359449 http://dx.doi.org/10.3389/fcell.2022.815205 Text en Copyright © 2022 Kim, Jang, Kim, Jang, Cho, Han, Song, Kim and Yang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Kim, Hyosuk
Jang, Yeongji
Kim, Eun Hye
Jang, Hochung
Cho, Haeun
Han, Geonhee
Song, Hyun Kyu
Kim, Sun Hwa
Yang, Yoosoo
Potential of Colostrum-Derived Exosomes for Promoting Hair Regeneration Through the Transition From Telogen to Anagen Phase
title Potential of Colostrum-Derived Exosomes for Promoting Hair Regeneration Through the Transition From Telogen to Anagen Phase
title_full Potential of Colostrum-Derived Exosomes for Promoting Hair Regeneration Through the Transition From Telogen to Anagen Phase
title_fullStr Potential of Colostrum-Derived Exosomes for Promoting Hair Regeneration Through the Transition From Telogen to Anagen Phase
title_full_unstemmed Potential of Colostrum-Derived Exosomes for Promoting Hair Regeneration Through the Transition From Telogen to Anagen Phase
title_short Potential of Colostrum-Derived Exosomes for Promoting Hair Regeneration Through the Transition From Telogen to Anagen Phase
title_sort potential of colostrum-derived exosomes for promoting hair regeneration through the transition from telogen to anagen phase
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8960251/
https://www.ncbi.nlm.nih.gov/pubmed/35359449
http://dx.doi.org/10.3389/fcell.2022.815205
work_keys_str_mv AT kimhyosuk potentialofcolostrumderivedexosomesforpromotinghairregenerationthroughthetransitionfromtelogentoanagenphase
AT jangyeongji potentialofcolostrumderivedexosomesforpromotinghairregenerationthroughthetransitionfromtelogentoanagenphase
AT kimeunhye potentialofcolostrumderivedexosomesforpromotinghairregenerationthroughthetransitionfromtelogentoanagenphase
AT janghochung potentialofcolostrumderivedexosomesforpromotinghairregenerationthroughthetransitionfromtelogentoanagenphase
AT chohaeun potentialofcolostrumderivedexosomesforpromotinghairregenerationthroughthetransitionfromtelogentoanagenphase
AT hangeonhee potentialofcolostrumderivedexosomesforpromotinghairregenerationthroughthetransitionfromtelogentoanagenphase
AT songhyunkyu potentialofcolostrumderivedexosomesforpromotinghairregenerationthroughthetransitionfromtelogentoanagenphase
AT kimsunhwa potentialofcolostrumderivedexosomesforpromotinghairregenerationthroughthetransitionfromtelogentoanagenphase
AT yangyoosoo potentialofcolostrumderivedexosomesforpromotinghairregenerationthroughthetransitionfromtelogentoanagenphase