Cargando…
Characterizing Pharmacokinetics in Children With Obesity—Physiological, Drug, Patient, and Methodological Considerations
Childhood obesity is an alarming public health problem. The pediatric obesity rate has quadrupled in the past 30 years, and currently nearly 20% of United States children and 9% of children worldwide are classified as obese. Drug distribution and elimination processes, which determine drug exposure...
Autores principales: | Gerhart, Jacqueline G., Balevic, Stephen, Sinha, Jaydeep, Perrin, Eliana M., Wang, Jian, Edginton, Andrea N., Gonzalez, Daniel |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8960278/ https://www.ncbi.nlm.nih.gov/pubmed/35359853 http://dx.doi.org/10.3389/fphar.2022.818726 |
Ejemplares similares
-
Development and Evaluation of a Virtual Population of Children with Obesity for Physiologically Based Pharmacokinetic Modeling
por: Gerhart, Jacqueline G., et al.
Publicado: (2021) -
Use of Real‐World Data and Physiologically‐Based Pharmacokinetic Modeling to Characterize Enoxaparin Disposition in Children With Obesity
por: Gerhart, Jacqueline G., et al.
Publicado: (2022) -
Use of physiologically‐based pharmacokinetic modeling to inform dosing of the opioid analgesics fentanyl and methadone in children with obesity
por: Gerhart, Jacqueline G., et al.
Publicado: (2022) -
Physiologically-Based Pharmacokinetic Modeling Characterizes the CYP3A-Mediated Drug-Drug Interaction Between Fluconazole and Sildenafil in Infants
por: Salerno, Sara N., et al.
Publicado: (2020) -
External Evaluation of Risperidone Population Pharmacokinetic Models Using Opportunistic Pediatric Data
por: Karatza, Eleni, et al.
Publicado: (2022)