Cargando…
Associations Between Abdominal Obesity Indices and Nonalcoholic Fatty Liver Disease: Chinese Visceral Adiposity Index
Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver metabolic disease worldwide. Up to 70%–80% of patients with NAFLD were obese, especially abdominal obesity. Many indicators of abdominal obesity have been reported, including waist circumference (WC), visceral obesity index (VAI), l...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8960385/ https://www.ncbi.nlm.nih.gov/pubmed/35360076 http://dx.doi.org/10.3389/fendo.2022.831960 |
_version_ | 1784677370686341120 |
---|---|
author | Chen, Xueyu Shi, Fengxue Xiao, Juan Huang, Fengyan Cheng, Fang Wang, Lihua Ju, Yanli Zhou, Yong Jia, Hongying |
author_facet | Chen, Xueyu Shi, Fengxue Xiao, Juan Huang, Fengyan Cheng, Fang Wang, Lihua Ju, Yanli Zhou, Yong Jia, Hongying |
author_sort | Chen, Xueyu |
collection | PubMed |
description | Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver metabolic disease worldwide. Up to 70%–80% of patients with NAFLD were obese, especially abdominal obesity. Many indicators of abdominal obesity have been reported, including waist circumference (WC), visceral obesity index (VAI), lipid accumulation (LAP), and Chinese VAI (CVAI). However, few studies investigated the associations between these indices with NAFLD. This present study aims to explore the associations between abdominal obesity indices with NAFLD. A total of 7,238 participants were involved in the cross-sectional study, and 1,584 participants were included in the longitudinal study from Jidong communities. NAFLD was assessed by abdominal ultrasonography. The trajectory of WC, VAI, LAP, and CVAI during 2013–2016 was identified by a group-based trajectory model. The logistic regression and Cox proportional hazards models analyzed the correlations and causality between abdominal obesity indices with NAFLD. In this study, the prevalence and incidence of NAFLD are approximately 44% and 26%, respectively. In the cross-sectional study, WC, VAI, LAP, and CVAI are associated with NAFLD. After adjustment for potential confounders, the moderate-rising and high-rising groups of CVAI had the highest risk of NAFLD in longitudinal analysis (hazard ratio (HR): 3.903, 95%CI: 2.434–6.259; HR: 5.694 95%CI: 3.098–10.464, respectively). Receiving operating characteristic curves show that CVAI has the best diagnostic value for NAFLD (area under the curve (AUC) = 0.868). CVAI is independently associated with the risk of NAFLD and may also have an important value to the diagnosis of NAFLD. |
format | Online Article Text |
id | pubmed-8960385 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-89603852022-03-30 Associations Between Abdominal Obesity Indices and Nonalcoholic Fatty Liver Disease: Chinese Visceral Adiposity Index Chen, Xueyu Shi, Fengxue Xiao, Juan Huang, Fengyan Cheng, Fang Wang, Lihua Ju, Yanli Zhou, Yong Jia, Hongying Front Endocrinol (Lausanne) Endocrinology Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver metabolic disease worldwide. Up to 70%–80% of patients with NAFLD were obese, especially abdominal obesity. Many indicators of abdominal obesity have been reported, including waist circumference (WC), visceral obesity index (VAI), lipid accumulation (LAP), and Chinese VAI (CVAI). However, few studies investigated the associations between these indices with NAFLD. This present study aims to explore the associations between abdominal obesity indices with NAFLD. A total of 7,238 participants were involved in the cross-sectional study, and 1,584 participants were included in the longitudinal study from Jidong communities. NAFLD was assessed by abdominal ultrasonography. The trajectory of WC, VAI, LAP, and CVAI during 2013–2016 was identified by a group-based trajectory model. The logistic regression and Cox proportional hazards models analyzed the correlations and causality between abdominal obesity indices with NAFLD. In this study, the prevalence and incidence of NAFLD are approximately 44% and 26%, respectively. In the cross-sectional study, WC, VAI, LAP, and CVAI are associated with NAFLD. After adjustment for potential confounders, the moderate-rising and high-rising groups of CVAI had the highest risk of NAFLD in longitudinal analysis (hazard ratio (HR): 3.903, 95%CI: 2.434–6.259; HR: 5.694 95%CI: 3.098–10.464, respectively). Receiving operating characteristic curves show that CVAI has the best diagnostic value for NAFLD (area under the curve (AUC) = 0.868). CVAI is independently associated with the risk of NAFLD and may also have an important value to the diagnosis of NAFLD. Frontiers Media S.A. 2022-03-10 /pmc/articles/PMC8960385/ /pubmed/35360076 http://dx.doi.org/10.3389/fendo.2022.831960 Text en Copyright © 2022 Chen, Shi, Xiao, Huang, Cheng, Wang, Ju, Zhou and Jia https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Chen, Xueyu Shi, Fengxue Xiao, Juan Huang, Fengyan Cheng, Fang Wang, Lihua Ju, Yanli Zhou, Yong Jia, Hongying Associations Between Abdominal Obesity Indices and Nonalcoholic Fatty Liver Disease: Chinese Visceral Adiposity Index |
title | Associations Between Abdominal Obesity Indices and Nonalcoholic Fatty Liver Disease: Chinese Visceral Adiposity Index |
title_full | Associations Between Abdominal Obesity Indices and Nonalcoholic Fatty Liver Disease: Chinese Visceral Adiposity Index |
title_fullStr | Associations Between Abdominal Obesity Indices and Nonalcoholic Fatty Liver Disease: Chinese Visceral Adiposity Index |
title_full_unstemmed | Associations Between Abdominal Obesity Indices and Nonalcoholic Fatty Liver Disease: Chinese Visceral Adiposity Index |
title_short | Associations Between Abdominal Obesity Indices and Nonalcoholic Fatty Liver Disease: Chinese Visceral Adiposity Index |
title_sort | associations between abdominal obesity indices and nonalcoholic fatty liver disease: chinese visceral adiposity index |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8960385/ https://www.ncbi.nlm.nih.gov/pubmed/35360076 http://dx.doi.org/10.3389/fendo.2022.831960 |
work_keys_str_mv | AT chenxueyu associationsbetweenabdominalobesityindicesandnonalcoholicfattyliverdiseasechinesevisceraladiposityindex AT shifengxue associationsbetweenabdominalobesityindicesandnonalcoholicfattyliverdiseasechinesevisceraladiposityindex AT xiaojuan associationsbetweenabdominalobesityindicesandnonalcoholicfattyliverdiseasechinesevisceraladiposityindex AT huangfengyan associationsbetweenabdominalobesityindicesandnonalcoholicfattyliverdiseasechinesevisceraladiposityindex AT chengfang associationsbetweenabdominalobesityindicesandnonalcoholicfattyliverdiseasechinesevisceraladiposityindex AT wanglihua associationsbetweenabdominalobesityindicesandnonalcoholicfattyliverdiseasechinesevisceraladiposityindex AT juyanli associationsbetweenabdominalobesityindicesandnonalcoholicfattyliverdiseasechinesevisceraladiposityindex AT zhouyong associationsbetweenabdominalobesityindicesandnonalcoholicfattyliverdiseasechinesevisceraladiposityindex AT jiahongying associationsbetweenabdominalobesityindicesandnonalcoholicfattyliverdiseasechinesevisceraladiposityindex |