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Proinflammatory cytokines induce rapid, NO-independent apoptosis, expression of chemotactic mediators and interleukin-32 secretion in human pluripotent stem cell-derived beta cells
AIMS/HYPOTHESIS: The aim of this study was to examine the effects of proinflammatory cytokines on cells of different developmental stages during the generation of stem cell-derived beta cells (SC-beta cells) from human pluripotent stem cells (hPSCs). We wanted to find out to what extent human SC-bet...
Autores principales: | Dettmer, Rabea, Niwolik, Isabell, Cirksena, Karsten, Yoshimoto, Toshiaki, Tang, Yadi, Mehmeti, Ilir, Gurgul-Convey, Ewa, Naujok, Ortwin |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8960637/ https://www.ncbi.nlm.nih.gov/pubmed/35122482 http://dx.doi.org/10.1007/s00125-022-05654-0 |
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