Pre-clinical safety and therapeutic efficacy of a plant-based alkaloid in a human colon cancer xenograft model

A high-throughput drug screen revealed that veratridine (VTD), a natural plant alkaloid, induces expression of the anti-cancer protein UBXN2A in colon cancer cells. UBXN2A suppresses mortalin, a heat shock protein, with dominant roles in cancer development including epithelial–mesenchymal transition...

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Detalles Bibliográficos
Autores principales: Freeling, Jessica L., Scholl, Jamie L., Eikanger, Morgan, Knoblich, Cole, Potts, Rashaun A., Anderson, David J., Rower, Joseph E., Farjoo, Mohammad Hadi, Zhao, Haotian, Pillatzki, Angela, Rezvani, Khosrow
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8960818/
https://www.ncbi.nlm.nih.gov/pubmed/35347121
http://dx.doi.org/10.1038/s41420-022-00936-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8960818/
https://www.ncbi.nlm.nih.gov/pubmed/35347121
http://dx.doi.org/10.1038/s41420-022-00936-3

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