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Artemisinin resistance in the malaria parasite, Plasmodium falciparum, originates from its initial transcriptional response
The emergence and spread of artemisinin-resistant Plasmodium falciparum, first in the Greater Mekong Subregion (GMS), and now in East Africa, is a major threat to global malaria elimination ambitions. To investigate the artemisinin resistance mechanism, transcriptome analysis was conducted of 577 P....
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8960834/ https://www.ncbi.nlm.nih.gov/pubmed/35347215 http://dx.doi.org/10.1038/s42003-022-03215-0 |
| _version_ | 1784677465005752320 |
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| author | Zhu, Lei van der Pluijm, Rob W. Kucharski, Michal Nayak, Sourav Tripathi, Jaishree White, Nicholas J. Day, Nicholas P. J. Faiz, Abul Phyo, Aung Pyae Amaratunga, Chanaki Lek, Dysoley Ashley, Elizabeth A. Nosten, François Smithuis, Frank Ginsburg, Hagai von Seidlein, Lorenz Lin, Khin Imwong, Mallika Chotivanich, Kesinee Mayxay, Mayfong Dhorda, Mehul Nguyen, Hoang Chau Nguyen, Thuy Nhien Thanh Miotto, Olivo Newton, Paul N. Jittamala, Podjanee Tripura, Rupam Pukrittayakamee, Sasithon Peto, Thomas J. Hien, Tran Tinh Dondorp, Arjen M. Bozdech, Zbynek |
| author_facet | Zhu, Lei van der Pluijm, Rob W. Kucharski, Michal Nayak, Sourav Tripathi, Jaishree White, Nicholas J. Day, Nicholas P. J. Faiz, Abul Phyo, Aung Pyae Amaratunga, Chanaki Lek, Dysoley Ashley, Elizabeth A. Nosten, François Smithuis, Frank Ginsburg, Hagai von Seidlein, Lorenz Lin, Khin Imwong, Mallika Chotivanich, Kesinee Mayxay, Mayfong Dhorda, Mehul Nguyen, Hoang Chau Nguyen, Thuy Nhien Thanh Miotto, Olivo Newton, Paul N. Jittamala, Podjanee Tripura, Rupam Pukrittayakamee, Sasithon Peto, Thomas J. Hien, Tran Tinh Dondorp, Arjen M. Bozdech, Zbynek |
| author_sort | Zhu, Lei |
| collection | PubMed |
| description | The emergence and spread of artemisinin-resistant Plasmodium falciparum, first in the Greater Mekong Subregion (GMS), and now in East Africa, is a major threat to global malaria elimination ambitions. To investigate the artemisinin resistance mechanism, transcriptome analysis was conducted of 577 P. falciparum isolates collected in the GMS between 2016–2018. A specific artemisinin resistance-associated transcriptional profile was identified that involves a broad but discrete set of biological functions related to proteotoxic stress, host cytoplasm remodelling, and REDOX metabolism. The artemisinin resistance-associated transcriptional profile evolved from initial transcriptional responses of susceptible parasites to artemisinin. The genetic basis for this adapted response is likely to be complex. |
| format | Online Article Text |
| id | pubmed-8960834 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | Nature Publishing Group UK |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-89608342022-04-20 Artemisinin resistance in the malaria parasite, Plasmodium falciparum, originates from its initial transcriptional response Zhu, Lei van der Pluijm, Rob W. Kucharski, Michal Nayak, Sourav Tripathi, Jaishree White, Nicholas J. Day, Nicholas P. J. Faiz, Abul Phyo, Aung Pyae Amaratunga, Chanaki Lek, Dysoley Ashley, Elizabeth A. Nosten, François Smithuis, Frank Ginsburg, Hagai von Seidlein, Lorenz Lin, Khin Imwong, Mallika Chotivanich, Kesinee Mayxay, Mayfong Dhorda, Mehul Nguyen, Hoang Chau Nguyen, Thuy Nhien Thanh Miotto, Olivo Newton, Paul N. Jittamala, Podjanee Tripura, Rupam Pukrittayakamee, Sasithon Peto, Thomas J. Hien, Tran Tinh Dondorp, Arjen M. Bozdech, Zbynek Commun Biol Article The emergence and spread of artemisinin-resistant Plasmodium falciparum, first in the Greater Mekong Subregion (GMS), and now in East Africa, is a major threat to global malaria elimination ambitions. To investigate the artemisinin resistance mechanism, transcriptome analysis was conducted of 577 P. falciparum isolates collected in the GMS between 2016–2018. A specific artemisinin resistance-associated transcriptional profile was identified that involves a broad but discrete set of biological functions related to proteotoxic stress, host cytoplasm remodelling, and REDOX metabolism. The artemisinin resistance-associated transcriptional profile evolved from initial transcriptional responses of susceptible parasites to artemisinin. The genetic basis for this adapted response is likely to be complex. Nature Publishing Group UK 2022-03-28 /pmc/articles/PMC8960834/ /pubmed/35347215 http://dx.doi.org/10.1038/s42003-022-03215-0 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
| spellingShingle | Article Zhu, Lei van der Pluijm, Rob W. Kucharski, Michal Nayak, Sourav Tripathi, Jaishree White, Nicholas J. Day, Nicholas P. J. Faiz, Abul Phyo, Aung Pyae Amaratunga, Chanaki Lek, Dysoley Ashley, Elizabeth A. Nosten, François Smithuis, Frank Ginsburg, Hagai von Seidlein, Lorenz Lin, Khin Imwong, Mallika Chotivanich, Kesinee Mayxay, Mayfong Dhorda, Mehul Nguyen, Hoang Chau Nguyen, Thuy Nhien Thanh Miotto, Olivo Newton, Paul N. Jittamala, Podjanee Tripura, Rupam Pukrittayakamee, Sasithon Peto, Thomas J. Hien, Tran Tinh Dondorp, Arjen M. Bozdech, Zbynek Artemisinin resistance in the malaria parasite, Plasmodium falciparum, originates from its initial transcriptional response |
| title | Artemisinin resistance in the malaria parasite, Plasmodium falciparum, originates from its initial transcriptional response |
| title_full | Artemisinin resistance in the malaria parasite, Plasmodium falciparum, originates from its initial transcriptional response |
| title_fullStr | Artemisinin resistance in the malaria parasite, Plasmodium falciparum, originates from its initial transcriptional response |
| title_full_unstemmed | Artemisinin resistance in the malaria parasite, Plasmodium falciparum, originates from its initial transcriptional response |
| title_short | Artemisinin resistance in the malaria parasite, Plasmodium falciparum, originates from its initial transcriptional response |
| title_sort | artemisinin resistance in the malaria parasite, plasmodium falciparum, originates from its initial transcriptional response |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8960834/ https://www.ncbi.nlm.nih.gov/pubmed/35347215 http://dx.doi.org/10.1038/s42003-022-03215-0 |
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