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Therapeutic Implications of Caffeic Acid in Cancer and Neurological Diseases

Caffeic acid (CA) is found abundantly in fruits, vegetables, tea, coffee, oils, and more. CA and its derivatives have been used for many centuries due to their natural healing and medicinal properties. CA possesses various biological and pharmacological activities, including antioxidant, anti-inflam...

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Autores principales: Alam, Manzar, Ahmed, Sarfraz, Elasbali, Abdelbaset Mohamed, Adnan, Mohd, Alam, Shoaib, Hassan, Md. Imtaiyaz, Pasupuleti, Visweswara Rao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8960963/
https://www.ncbi.nlm.nih.gov/pubmed/35359383
http://dx.doi.org/10.3389/fonc.2022.860508
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author Alam, Manzar
Ahmed, Sarfraz
Elasbali, Abdelbaset Mohamed
Adnan, Mohd
Alam, Shoaib
Hassan, Md. Imtaiyaz
Pasupuleti, Visweswara Rao
author_facet Alam, Manzar
Ahmed, Sarfraz
Elasbali, Abdelbaset Mohamed
Adnan, Mohd
Alam, Shoaib
Hassan, Md. Imtaiyaz
Pasupuleti, Visweswara Rao
author_sort Alam, Manzar
collection PubMed
description Caffeic acid (CA) is found abundantly in fruits, vegetables, tea, coffee, oils, and more. CA and its derivatives have been used for many centuries due to their natural healing and medicinal properties. CA possesses various biological and pharmacological activities, including antioxidant, anti-inflammatory, anticancer, and neuroprotective effects. The potential therapeutic effects of CA are mediated via repression and inhibition of transcription and growth factors. CA possesses potential anticancer and neuroprotective effects in human cell cultures and animal models. However, the biomolecular interactions and pathways of CA have been described highlighting the target binding proteins and signaling molecules. The current review focuses on CA’s chemical, physical, and pharmacological properties, including antioxidant, anti-inflammatory, anticancer, and neuroprotective effects. We further described CA’s characteristics and therapeutic potential and its future directions.
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spelling pubmed-89609632022-03-30 Therapeutic Implications of Caffeic Acid in Cancer and Neurological Diseases Alam, Manzar Ahmed, Sarfraz Elasbali, Abdelbaset Mohamed Adnan, Mohd Alam, Shoaib Hassan, Md. Imtaiyaz Pasupuleti, Visweswara Rao Front Oncol Oncology Caffeic acid (CA) is found abundantly in fruits, vegetables, tea, coffee, oils, and more. CA and its derivatives have been used for many centuries due to their natural healing and medicinal properties. CA possesses various biological and pharmacological activities, including antioxidant, anti-inflammatory, anticancer, and neuroprotective effects. The potential therapeutic effects of CA are mediated via repression and inhibition of transcription and growth factors. CA possesses potential anticancer and neuroprotective effects in human cell cultures and animal models. However, the biomolecular interactions and pathways of CA have been described highlighting the target binding proteins and signaling molecules. The current review focuses on CA’s chemical, physical, and pharmacological properties, including antioxidant, anti-inflammatory, anticancer, and neuroprotective effects. We further described CA’s characteristics and therapeutic potential and its future directions. Frontiers Media S.A. 2022-03-10 /pmc/articles/PMC8960963/ /pubmed/35359383 http://dx.doi.org/10.3389/fonc.2022.860508 Text en Copyright © 2022 Alam, Ahmed, Elasbali, Adnan, Alam, Hassan and Pasupuleti https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Alam, Manzar
Ahmed, Sarfraz
Elasbali, Abdelbaset Mohamed
Adnan, Mohd
Alam, Shoaib
Hassan, Md. Imtaiyaz
Pasupuleti, Visweswara Rao
Therapeutic Implications of Caffeic Acid in Cancer and Neurological Diseases
title Therapeutic Implications of Caffeic Acid in Cancer and Neurological Diseases
title_full Therapeutic Implications of Caffeic Acid in Cancer and Neurological Diseases
title_fullStr Therapeutic Implications of Caffeic Acid in Cancer and Neurological Diseases
title_full_unstemmed Therapeutic Implications of Caffeic Acid in Cancer and Neurological Diseases
title_short Therapeutic Implications of Caffeic Acid in Cancer and Neurological Diseases
title_sort therapeutic implications of caffeic acid in cancer and neurological diseases
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8960963/
https://www.ncbi.nlm.nih.gov/pubmed/35359383
http://dx.doi.org/10.3389/fonc.2022.860508
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