Structural analysis of P450 AmphL from Streptomyces nodosus provides insights into substrate selectivity of polyene macrolide antibiotic biosynthetic P450s

AmphL is a cytochrome P450 enzyme that catalyzes the C8 oxidation of 8-deoxyamphotericin B to the polyene macrolide antibiotic, amphotericin B. To understand this substrate selectivity, we solved the crystal structure of AmphL to a resolution of 2.0 Å in complex with amphotericin B and performed mol...

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Detalles Bibliográficos
Autores principales: Amaya, Jose A., Lamb, David C., Kelly, Steven L., Caffrey, Patrick, Murarka, Vidhi C., Poulos, Thomas L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8960966/
https://www.ncbi.nlm.nih.gov/pubmed/35189143
http://dx.doi.org/10.1016/j.jbc.2022.101746

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