Pretransition state and apo structures of the filament-forming enzyme SgrAI elucidate mechanisms of activation and substrate specificity

Enzyme filamentation is a widespread phenomenon that mediates enzyme regulation and function. For the filament-forming sequence-specific DNA endonuclease SgrAI, the process of filamentation both accelerates its DNA cleavage activity and expands its DNA sequence specificity, thus allowing for many ad...

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Detalles Bibliográficos
Autores principales: Shan, Zelin, Ghadirian, Niloofar, Lyumkis, Dmitry, Horton, Nancy.C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8960973/
https://www.ncbi.nlm.nih.gov/pubmed/35202658
http://dx.doi.org/10.1016/j.jbc.2022.101760

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